Cognitive behaviour therapy-trained staff’s views on professional accreditation

Many cognitive behaviour therapy (CBT) trained mental health professionals seek non-mandatory accreditation with the British Association for Behavioural and Cognitive Psychotherapies (BABCP), despite self-regulation of talking therapies being a divisive issue. This raises the question: what views do CBT-trained mental health professionals have towards BABCP accreditation and what motivates them to become accredited? This qualitative study recruited seven postgraduate CBT-trained mental health professionals from NHS Greater Glasgow and Clyde during 2015. Individual semi-structured interviews were completed and verbatim transcripts produced. Thematic analysis revealed the value participants place on accreditation, and that an absence of motivating factors and barriers during the application process means that not all CBT therapists become accredited

Minimal Betti Numbers

We give conditions for determining the extremal behavior for the (graded) Betti numbers of squarefree monomial ideals. For the case of non-unique minima, we give several conditions which we use to produce infinite families, exponentially growing with dimension, of Hilbert functions which have no smallest (graded) Betti numbers among squarefree monomial ideals and all ideals. For the case of unique minima, we give two families of Hilbert functions, one with exponential and one with linear growth as dimension grows, that have unique minimal Betti numbers among squarefree monomial ideals

Avian diversification in the afrotropics

Widespread bird species endemic to the lowlands of the Guineo-Congolian rainforest of Africa have traditionally been thought to lack substantial intraspecific structure. This view owes largely to their widespread distributions coupled with the absence of discrete geographic variation in plumage. In the following chapters I examine the phylogeographic patterns of three such species using a combination of molecular and morphometric data. The three species investigated are the Green Hylia (Hylia prasina), the Red-tailed Bristlebill (Bleda syndactylus), and the Yellow-whiskered Greenbul (Andropadus latirostris). Using the phylogeographic patterns from these data, I assess 1) models of rainforest species diversification, 2) current taxonomy, and 3) implications for conservation of lowland rainforests. In contrast to the lack of discrete plumage variation in these species, phylogeographic analyses reveal a high degree molecular and morphological divergence. Furthermore, general patterns of geographical structure of the mtDNA data are largely congruent among the three species. Each species has unique mtDNA haplotype groups in Liberia, Ghana, Cameroon-Gabon, Central African Republic, and the eastern Democratic Republic of Congo. Andropadus latirostris, which also occurs in montane forests, has unique haplotype groups in these montane regions. Taken together the patterns of geographic variation in molecular and morphological datasets from these three species suggest a history of allopatric divergence via genetic drift, consistent with predictions of refugial diversification. There is also some evidence for a potential role for divergent selection along a longitudinal temperature gradient in shaping the morphometric diversity in Andropadus latirostris. Despite their widespread distributions and the potential for high gene flow, these three species exhibit a remarkable level of geographic structure across the lowland rainforest. This contradicts the prevailing view of widespread lowland species as large panmictic populations. This significant geographic structure has important implications for species and habitat conservation in Africa, where lowland forest is typically viewed as a continuous block of homogeneous habitat. The implication is habitat loss in one area would not result in a substantial loss of biodiversity because many of the species are widely distributed. The geographic structure evident in these data suggests that that is not the case

Sagittal Subtalar and Talocrural Joint Assessment With Weight-Bearing Fluoroscopy During Barefoot Ambulation

Background: Identifying talar position during ambulation has proved difficult as the talus lacks palpable landmarks for skin marker placement and more invasive methodologies such as bone pins are not practical for most clinical subjects. A fluoroscopic motion system was used to track the talus and calcaneus, allowing kinematic analysis of the talocrural and subtalar joints. Methods: Thirteen male subjects (mean age 22.9 ± 3.0 years) previously screened for normal gait were tested. A fluoroscopy unit was used to collect images at 120 fps during stance. Sagittal motion of the talocrural and subtalar joints were analyzed. Results: The intersubject mean and standard deviation values for all 58 trials of 13 subjects are reported. Maximum talocrural joint plantarflexion of 11.2 degrees (4.3 degrees of standard deviation) occurred at 11% stance and maximum dorsiflexion of −6.9 degrees (5.6 degrees of standard deviation) occurred at 85%. Maximum subtalar joint plantarflexion of 4.8 degrees (1.0 degrees of standard deviation) occurred at 96% stance and maximum dorsiflexion of −3.6 degrees (2.3 degrees of standard deviation) occurred at 30%. Talocrural and subtalar range of motion values during stance were 18.1 and 8.4 degrees, respectively. Conclusion: Existing fluoroscopic technology was capable of defining sagittal plane talocrural and subtalar motion during gait. These kinematic results compare favorably with more invasive techniques. This type of assessment could support more routine analysis of in vivo bony motion during gait. Clinical Relevance: Fluoroscopic technology offers improved sagittal plane motion evaluation during weight-bearing with potential application in patients with end-stage ankle arthritis, postoperative ankle replacements and fusions, and orthotics and braces

The Potential of Differential Astrometric Interferometry from the High Antarctic Plateau

The low infrared background and high atmospheric transparency are the principal advantages of Antarctic Plateau sites for astronomy. However, the poor seeing (between one and three arcseconds) negates much of the sensitivity improvements that the Antarctic atmosphere offers, compared to mid-latitude sites such as Mauna Kea or Cerro Paranal. The seeing at mid-latitude sites, though smaller in amplitude, is dominated by turbulence at altitudes of 10 to 20 km. Over the Antarctic plateau, virtually no high altitude turbulence is present in the winter. The mean square error for an astrometric measurement with a dual-beam, differential astrometric interferometer in the very narrow angle regime is proportional to the integral of $h^2 C_N^2(h)$. Therefore, sites at which the turbulence occurs only at low altitudes offer large gains in astrometric precision. We show that a modest interferometer at the South Pole can achieve 10 $\mu$as differential astrometry 300 times faster than a comparable interferometer at a good mid-latitude site, in median conditions. Science programs that would benefit from such an instrument include planet detection and orbit determination and astrometric observation of stars microlensed by dark matter candidates.Comment: Accepted for publication in Publications of the Astronomical Society of Australi

Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel

Cyclic nucleotide-gated (CNG) ion channels are nonselective cation channels, essential for visual and olfactory sensory transduction. Although the channels include voltage-sensor domains (VSDs), their conductance is thought to be independent of the membrane potential, and their gating regulated by cytosolic cyclic nucleotide–binding domains. Mutations in these channels result in severe, degenerative retinal diseases, which remain untreatable. The lack of structural information on CNG channels has prevented mechanistic understanding of disease-causing mutations, precluded structure-based drug design, and hampered in silico investigation of the gating mechanism. To address this, we built a 3D model of the cone tetrameric CNG channel, based on homology to two distinct templates with known structures: the transmembrane (TM) domain of a bacterial channel, and the cyclic nucleotide-binding domain of the mouse HCN2 channel. Since the TM-domain template had low sequence-similarity to the TM domains of the CNG channels, and to reconcile conflicts between the two templates, we developed a novel, hybrid approach, combining homology modeling with evolutionary coupling constraints. Next, we used elastic network analysis of the model structure to investigate global motions of the channel and to elucidate its gating mechanism. We found the following: (i) In the main mode of motion, the TM and cytosolic domains counter-rotated around the membrane normal. We related this motion to gating, a proposition that is supported by previous experimental data, and by comparison to the known gating mechanism of the bacterial KirBac channel. (ii) The VSDs could facilitate gating (supplementing the pore gate), explaining their presence in such ‘voltage-insensitive’ channels. (iii) Our elastic network model analysis of the CNGA3 channel supports a modular model of allosteric gating, according to which protein domains are quasi-independent: they can move independently, but are coupled to each other allosterically

Highly sensitive and specific detection of E. coli by a SERS nanobiosensor chip utilizing metallic nanosculptured thin films

A nanobiosensor chip, utilizing surface enhanced Raman spectroscopy (SERS) on nanosculptured thin films (nSTFs) of silver, was shown to detect Escherichia coli (E. coli) bacteria down to the concentration level of a single bacterium. The sensor utilizes highly enhanced plasmonic nSTFs of silver on a silicon platform for the enhancement of Raman bands as checked with adsorbed 4-aminothiophenol molecules. T-4 bacteriophages were immobilized on the aforementioned surface of the chip for the specific capture of target E. coli bacteria. To demonstrate that no significant non-specific immobilization of other bacteria occurs, three different, additional bacterial strains, Chromobacterium violaceum, Paracoccus denitrificans and Pseudomonas aeruginosa were used. Furthermore, experiments performed on an additional strain of E. coli to address the specificity and reusability of the sensor showed that the sensor operates for different strains of E. coli and is reusable. Time resolved phase contrast microscopy of the E. coli-T4 bacteriophage chip was performed to study its interaction with bacteria over time. Results showed that the present sensor performs a fast, accurate and stable detection of E. coli with ultra-small concentrations of bacteria down to the level of a single bacterium in 10 μl volume of the sample

Supplementary materials for "Understanding University Student Priorities for Mental Health and Well-being Support: A Mixed-Methods Exploration using the Person-Based Approach"

These supplementary materials comprise some of the study materials used in a mixed-methods exploration of student engagement with and priorities for well-being and mental health support at university. They include the content of an online survey instrument (part 1, quantitative), the focus group discussion schedule (part 2, qualitative), and anonymised data from the survey and focus groups. Research took place in the summer of 2020; the participants were students of the University of Bath at that time.Full details of the methodology may be found in the associated paper. The survey instrument and focus group schedule are included in the dataset.The data archived here has been anonymised in line with the nature of informed consent obtained from participants.Transcripts and descriptively analysed survey data are in MS Word (docx) format. Anonymised and pre-processed survey data are in MS Excel (xlsx) format. The qualitative analysis was conducted in NVivo.The online survey was open between 25th June and 5th August 2020. The three focus groups took place in July 2020