Synthesis, characterization and prediction of anticancer potentiality of some novel green nanoparticles by molecular docking and ADMET techniques

ABSTRACT. Anticancer potentiality of some newly synthesized Nano-Biginelli compounds with the help of enzyme extracted naturally from plants is reported. The biological synthesis of nanoparticles via nano biotechnology processes have a significant potential to enhance the production without the use of harsh, toxic, and expensive chemicals commonly used in conventional physical and chemical processes. The compounds have been characterized on the basis of UV, FTIR, XRD and SEM studies in order to depict the formation of nanoparticles. Using the combination of docking and ADMET techniques, we have tried to predict the anti-cancer potentiality as well as its area of target, i.e. cancer cell to trigger the anti-cancer reaction. Results indicate that the compound 1 (ethyl-6-methyl-2-oxo-4-(4-methoxyphenyl)-1,2,3,4-tetrahydropyrimidin-5-carboxylate) has possible virtual leads to design novel human Aurora B kinase inhibitor.               KEY WORDS: Nano biotechnology, Green chemistry, Enzymes, Drug research Bull. Chem. Soc. Ethiop. 2019, 33(3), 493-504.DOI: https://dx.doi.org/10.4314/bcse.v33i3.1

Asymmetric Substrate Integrated Waveguide Leaky Wave Antenna with Open Stop Band Suppression and Radiation Efficiency Equalization through Broadside

A planar asymmetric substrate integrated wave¬guide leaky wave antenna is proposed with open stop band suppression and radiation efficiency equalization through broadside for the Ku-band. The stop-band behavior exhib¬ited at broadside in the 1-D periodic structure is signifi¬cantly reduced using reflection cancellation technique by placing the two slots at a quarter distance within the unit cell. Furthermore, asymmetric technique is applied. The asymmetry is introduced with respect to both axial and transversal axis of the structure so as to match the at-broadside Bloch impedance and off-broadside Bloch im¬pedance. This provides total open stop band suppression and radiation efficiency improvement as well as equaliza-tion through broadside. The problem is analyzed with the help of Bloch impedance behavior. For illustration of the above techniques; single slot, double slot and asymmetric designs are developed for the proposed leaky wave an¬tenna. The final asymmetric design after optimization is fabricated. Measured results are almost consistent with the simulation results with complete suppression of open stop band, efficiency improvement and equalization through broadside providing continuous beam scanning from –32° to +27° with constant gain of ~12.5 dBi

Genetic divergence evaluation of apple germplasm by D2 multivariate analysis

Genetic divergence was worked out in the new germplasm of apple (Malus × domestica Borkh.) including 42 genotypes. Mahalanobis's D2 statistics was applied for identifying the potential parents to be involved in the hybridization programme for trait specific improvement or selecting better segregants. On the basis of performance for various traits, genotypes were grouped into three clusters and maximum numbers of genotypes i.e. 28 were accommodated in cluster I , while 10 and 4 genotypes were arranged in cluster II and III respectively. The average intra cluster distance was maximum in cluster II (2.214) and minimum in cluster III (1.212). Inter cluster distance was maximum between cluster II and III (5.077) indicating that hybridization between genotypes from cluster II and III can be utilized for getting the superior recombinants in segregating generations. On the basis of cluster means for various characters , cluster II was found superior for shoot thickness (0.34cm), inter - nodal length (2.38cm), number of lenticels (62.10) and leaf blade length (8.79cm) whereas cluster III was found superior for leaf blade width (5.10cm), petiole length (2.64cm) and leaf blade ratio (3.62). Hence, hybridization between parents from cluster II and cluster III for these characters can produce better recombinants in segregating generations

Crowdfunding in Africa: Opportunities and Challenges

publishedVersio

Inclusion, measurement and relevance… and Covid-19

This is an accepted manuscript of an article published by Springer in Postdigital Science and Education on 17/08/2020, available online: https://doi.org/10.1007/s42438-020-00182-9 The accepted version of the publication may differ from the final published version.This paper addresses the theme of ‘widening student access, participation and lifelong learning’ within the wider issue of ‘measuring excellence’ in the UK higher education and finds them both to be problematic. An earlier paper entitled ‘Inclusion in an age of mobility’ (Traxler 2016) written over 4 years ago made the case that the inclusion agenda of the UK higher education of 1990s was largely a failure in its own terms but had in any case been made irrelevant by the subsequent onset of pervasive and ubiquitous connectivity and mobility, profoundly transforming the production, ownership, distribution and nature of learning and knowing and problematising the role and status of universities and lecturers.Published onlin

Half Mode Substrate Integrated Waveguide Leaky Wave Antenna with Broadside Gain Enhancement for Ku-Band Applications

A miniaturized frequency scanned leaky wave antenna (LWA) based on half mode substrate integrated waveguide (HMSIW) with open stop-band suppression is proposed. The modified cross-slot is etched on the top of HMSIW as the radiating element. The folded and unfolded ground plane designs of the proposed HMSIW LWA are compared and analyzed w.r.t their bloch impedance characteristics and it is found that further miniaturization and gain improvement at broadside by ~ 2dBi are achieved for folded ground plane design. The proposed LWA scans a region from -40° to +24° as the frequency range increases from 12 to 17 GHz with broadside at 15.5 GHz. The HMSIW LWA with folded ground plane is fabricated and its performance is experimentally measured showing the close agreement between the simulation and the measured results

Asymmetric Substrate Integrated Waveguide Leaky Wave Antenna with Open Stop Band Suppression and Radiation Efficiency Equalization Through Broadside

A planar asymmetric substrate integrated wave¬guide leaky wave antenna is proposed with open stop band suppression and radiation efficiency equalization through broadside for the Ku-band. The stop-band behavior exhib¬ited at broadside in the 1-D periodic structure is signifi¬cantly reduced using reflection cancellation technique by placing the two slots at a quarter distance within the unit cell. Furthermore, asymmetric technique is applied. The asymmetry is introduced with respect to both axial and transversal axis of the structure so as to match the at-broadside Bloch impedance and off-broadside Bloch im¬pedance. This provides total open stop band suppression and radiation efficiency improvement as well as equaliza-tion through broadside. The problem is analyzed with the help of Bloch impedance behavior. For illustration of the above techniques; single slot, double slot and asymmetric designs are developed for the proposed leaky wave an¬tenna. The final asymmetric design after optimization is fabricated. Measured results are almost consistent with the simulation results with complete suppression of open stop band, efficiency improvement and equalization through broadside providing continuous beam scanning from –32° to +27° with constant gain of ~12.5 dBi