La igualdad de género en el contexto público actual: la educación y el aprendizaje como elementos clave en su consecución

This article begins by highlighting the importance that knowledge and learning have in the current context to face the enormous challenges that we face as a society. Special emphasis is placed on the impact that COVID-19 has had at all levels, especially as far as the gender issue is concerned, and the setback that has been suffered in this area as a consequence of the pandemic, at the same time. time that highlights the importance of the former as a growth factor. The main existing strategies and public policies at the European level with a view to achieving gender equality are described below. To then analyze the main manifestations that the principle of equality has in the public sector (state and regional) and the verification of whether said equality is really a reality or an aspiration whose achievement becomes necessary if we want to achieve a more intelligent, sustainable and integrative. Finally, the role that education and learning have to achieve the principle of equality is analyzed, making special mention of the learning of women and girls in STEM careers as one of the main tools to face the great challenges. that will be presented to humanity in the present and in the future.El presente artículo comienza poniendo de manifiesto la importancia que el conocimiento y el aprendizaje tienen en el contexto actual para hacer frente a los enormes retos a los que nos enfrentamos como sociedad. Se hace un especial énfasis en el impacto que la COVID-19 ha supuesto a todos los niveles, especialmente en lo que a la cuestión de género se refiere, y el retroceso que se ha sufrido en esta materia como consecuencia de la pandemia, al mismo tiempo que se destaca la importancia de aquélla como factor de crecimiento. A continuación se describen las principales estrategias y políticas públicas existentes a nivel europeo de cara a la consecución de la igualdad de género. Seguidamente se analizan las principales manifestaciones que el principio de igualdad tiene en el sector público (estatal y autonómico) con el fin de comprobar si realmente dicha igualdad es una realidad o una aspiración cuya consecución se torna necesaria si queremos conseguir una sociedad más inteligente, sostenible e integradora. Para finalizar se analiza el papel que la educación y el aprendizaje tienen en la consecución del principio de igualdad, haciendo una especial mención al aprendizaje de mujeres y niñas en las carreras STEM como una de las principales herramientas para hacer frente a los grandes retos y desafíos que se nos plantearán en el presente y en el futuro a la humanidad

Las actas capitulares como fuente para la historia urbana.

Sin resume

Las actas capitulares como fuente para la historia urbana.

Sin resume

Follow-up of late-onset Pompe disease patients with muscle magnetic resonance imaging reveals increase in fat replacement in skeletal muscles

Altres ajuts: This investigation was sponsored by the following grants, one from Sanofi Genzyme and another from the Spanish Ministry of Health, Fondos FEDER-ISCIII. Isabel Illa has received speaker honorarium from Grifols and Sanofi-Genzyme. Jordi Díaz-Manera has received speaker honorarium from PTC Therapeutics and Sanofi-Genzyme. The authors of this manuscript certify that they comply with the ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia, and Muscle.42Late-onset Pompe disease (LOPD) is a genetic disorder characterized by progressive degeneration of the skeletal muscles produced by a deficiency of the enzyme acid alpha-glucosidase. Enzymatic replacement therapy with recombinant human alpha-glucosidase seems to reduce the progression of the disease; although at the moment, it is not completely clear to what extent. Quantitative muscle magnetic resonance imaging (qMRI) is a good biomarker for the follow-up of fat replacement in neuromuscular disorders. The aim of this study was to describe the changes observed in fat replacement in skeletal muscles using qMRI in a cohort of LOPD patients followed prospectively. A total of 36 LOPD patients were seen once every year for 4 years. qMRI, several muscle function tests, spirometry, activities of daily living scales, and quality-of-life scales were performed on each visit. Muscle MRI consisted of two-point Dixon studies of the trunk and thigh muscles. Computer analysis of the images provided the percentage of muscle degenerated and replaced by fat in every muscle (known as fat fraction). Longitudinal analysis of the measures was performed using linear mixed models applying the Greenhouse-Geisser test. We detected a statistically significant and continuous increase in mean thigh fat fraction both in treated (+5.8% in 3 years) and in pre-symptomatic patients (+2.6% in 3years) (Greenhouse-Geisser p < 0.05). As an average, fat fraction increased by 1.9% per year in treated patients, compared with 0.8% in pre-symptomatic patients. Fat fraction significantly increased in every muscle of the thighs. We observed a significant correlation between changes observed in fat fraction in qMRI and changes observed in the results of the muscle function tests performed. Moreover, we identified that muscle performance and mean thigh fat fraction at baseline visit were independent parameters influencing fat fraction progression over 4 years (analysis of covariance, p < 0.05). Our study identifies that skeletal muscle fat fraction continues to increase in patients with LOPD despite the treatment with enzymatic replacement therapy. These results suggest that the process of muscle degeneration is not stopped by the treatment and could impact muscle function over the years. Hereby, we show that fat fraction along with muscle function tests can be considered a good outcome measures for clinical trials in LOPD patients

Fernando Huarte Morton (1921-2011): libro homenaje

La figura de Fernando Huarte Morton (1921-2011) tiene un gran significado para el mundo de las bibliotecas, el libro antiguo y la bibliografía española y goza de un profundo respeto, simpatía y admiración para todos aquellos que le conocieron y trataron personalmente. Desarrolló la mayor parte de su carrera profesional en la Biblioteca de la Universidad Complutense de Madrid, de la que fue director entre 1975 y 1986, contribuyendo a su modernización desde varios ámbitos: el reconocimiento institucional; la profesionalización del personal; la centralización de los fondos; la normalización de los procesos y servicios; el inicio de la mecanización del catálogo y la preocupación por el fondo antiguo y por la existencia de un edificio para albergar la gran biblioteca general. Con estas acciones, las bases de la biblioteca del siglo XXI estaban puestas. Es por este motivo, que la Biblioteca de la Universidad Complutense, institución a la que dedicó tantos años de su vida, quiera rendirle un sentido homenaje a través de la publicación de este libro en el que participan muchos de los bibliotecarios que le conocieron y que han querido dar a conocer su profesionalidad como bibliotecario, su rigor científico como estudioso e investigador y su atrayente personalidad llena de sentido del humor y de ironía

Critical Discourse Analysis of Media Texts

El volumen presenta una panorámica del Análisis Crítico del Discurso de los textos mediáticos. El Análisis Crítico del Discurso es un modelo que parte de la Lingüística Crítica, basada a su vez en la Gramática Funcional de M. A. K. Halliday. En el volumen se resumen los principales enfoques de esta teoría. El volumen está compuesto de diversos artículos en los que se analizan diferentes casos concretos de los discursos de los medios de comunicación de masas (discurso informativo, discurso publicitario, discurso televisivo y discurso fílmico)The volume presents an overview of Critical Discourse Analysis of media texts. Critical Discourse Analysis is a framework departing from Critical Linguistics, which is based, in turn, on Functional Grammar as developed by M. A. K. Halliday. In this volume several approaches to Critical Discourse Analysis are summed up. In addition, the volume is composed by several papers where diverse concrete cases of media discourses are analysed (news discourse, advertisement discourse, television discourse and filmic discourse

In vivo partial cellular reprogramming enhances liver plasticity and regeneration.

Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a mouse model that enables the inducible expression of the four Yamanaka factors (Oct-3/4, Sox2, Klf4, and c-Myc, or 4F) specifically in hepatocytes. Transient in vivo 4F expression induces partial reprogramming of adult hepatocytes to a progenitor state and concomitantly increases cell proliferation. This is indicated by reduced expression of differentiated hepatic-lineage markers, an increase in markers of proliferation and chromatin modifiers, global changes in DNA accessibility, and an acquisition of liver stem and progenitor cell markers. Functionally, short-term expression of 4F enhances liver regenerative capacity through topoisomerase2-mediated partial reprogramming. Our results reveal that liver-specific 4F expression in vivo induces cellular plasticity and counteracts liver failure, suggesting that partial reprogramming may represent an avenue for enhancing tissue regeneration

Alfabetización en Ciencias de la Tierra

p. 117-129Este trabajo describe qué se entiende por una persona alfabetizada en ciencias de la Tierra y selecciona los conocimientos básicos que debería poseer todo estudiante al finalizar la educación obligatoria, de forma que pueda disponer de una idea global sobre cómo funciona el planeta en que vive. Formula las diez ideas clave que sintetizan esos conocimientos básicos y los conceptos, principios y teorías que las sustentan, así como los procedimientos utilizados para construir estos conocimientos, para refutarlos o validarlos. La propuesta está pensada desde una perspectiva holística, que entiende la Tierra como un sistema en el que se producen interacciones entre sus componentes. Entre ellas se destacan las que tienen lugar entre la humanidad y el planeta.S

PDGF-BB serum levels are decreased in adult onset Pompe patients

Adult onset Pompe disease is a genetic disorder characterized by slowly progressive skeletal and respiratory muscle weakness. Symptomatic patients are treated with enzymatic replacement therapy with human recombinant alfa glucosidase. Motor functional tests and spirometry are commonly used to follow patients up. However, a serological biomarker that correlates with the progression of the disease could improve follow-up. We studied serum concentrations of TGFβ, PDGF-BB, PDGF-AA and CTGF growth factors in 37 adult onset Pompe patients and 45 controls. Moreover, all patients performed several muscle function tests, conventional spirometry, and quantitative muscle MRI using 3-point Dixon. We observed a statistically significant change in the serum concentration of each growth factor in patients compared to controls. However, only PDGF-BB levels were able to differentiate between asymptomatic and symptomatic patients, suggesting its potential role in the follow-up of asymptomatic patients. Moreover, our results point to a dysregulation of muscle regeneration as an additional pathomechanism of Pompe disease