Physics at COSY

The COSY accelerator in J\'ulich is presented together with its internal and external detectors. The physics programme performed recently is discussed with emphasis on strangeness physics.Comment: Invited talk given at the "10th International Symposium on Meson-Nucleon Physics and the Structure of the Nucleon (MENU04)," IHEP, Beijing, China, 30/Aug.-4/Sept./0

Quantitative diffusion tensor MR imaging of the brain: field strength related variance of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) scalars

The objectives were to study the "impact” of the magnetic field strength on diffusion tensor imaging (DTI) metrics and also to determine whether magnetic-field-related differences in T2-relaxation times of brain tissue influence DTI measurements. DTI was performed on 12 healthy volunteers at 1.5 and 3.0 Tesla (within 2 h) using identical DTI scan parameters. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured at multiple gray and white matter locations. ADC and FA values were compared and analyzed for statistically significant differences. In addition, DTI measurements were performed at different echo times (TE) for both field strengths. ADC values for gray and white matter were statistically significantly lower at 3.0 Tesla compared with 1.5 Tesla (% change between −1.94% and −9.79%). FA values were statistically significantly higher at 3.0 Tesla compared with 1.5 Tesla (% change between +4.04 and 11.15%). ADC and FA values are not significantly different for TE=91ms and TE=125ms. Thus, ADC and FA values vary with the used field strength. Comparative clinical studies using ADC or FA values should consequently compare ADC or FA results with normative ADC or FA values that have been determined for the field strength use

Portal vein embolization using a Histoacryl/Lipiodol mixture before right liver resection

Purpose: The purpose of this retrospective study was to evaluate the efficacy and safety of percutaneous transhepatic portal vein embolization (PVE) of the right liver lobe using Histoacryl/Lipiodol mixture to induce contralateral liver hypertrophy before right-sided (or extended right-sided) hepatectomy in patients with primarily unresectable liver tumors. Methods: Twenty-one patients (9 females and 12 males) underwent PVE due to an insufficient future liver remnant; 17 showed liver metastases and 4 suffered from biliary cancer. Imaging was performed prior to and 4 weeks after PVE. Surgery was scheduled for 1 week after a CT or MRI control. The primary study end point was technical success, defined as complete angiographical occlusion of the portal vein. The secondary study end point was evaluation of liver hypertrophy by CT and MRI volumetry and transfer to operability. Results: In all the patients, PVE could be performed with a with a Histoacryl/Lipiodol mixture (n = 20) or a Histoacryl/ Lipiodol mixture with microcoils (n = 1). No procedure-related complications occurred. The volume of the left liver lobe increased significantly (p < 0.0001) by 28% from a mean of 549 ml to 709 ml. Eighteen of twenty-one patients (85.7%) could be transferred to surgery, and the intended resection could be performed as planned in 13/18 (72.3%) patients. Conclusion: Preoperative right-sided PVE using a Histoacryl/Lipiodol mixture is a safe technique and achieves a sufficient hypertrophy of the future liver remnant in the left liver lobe

Anisotropic phantoms for quantitative diffusion tensor imaging and fiber-tracking validation

Different fiber materials (hemp, linen, viscose rayon, polyamide and dyneema twine) were tested for their suitability as fiber phantoms for diffusion tensor imaging (DTI) calibration on clinical magnetic resonance imaging systems with common diffusion-weighted echo planar imaging sequences. Additionally, the potential for fiber tracking validation of these fiber phantoms was investigated. For phantom manufacturing the fibers were wound up into a bundle of parallel fibers enwrapped by plastic ribbon. The most homogenously distributed fractional anisotropy (FA) values (0.63 ± 0.10) were determined in the dyneema and polyamide (0.3 ± 0.1) fiber phantom. FA values in the viscose, linen and hemp bundles were at high variations (about 0.2 ± 0.10). The dispersion of the direction of the principal eigenvector in the polyamide and dyneema phantom was less than 7°, for the other fiber phantoms it was over 30°. Thus, the presented results may indicate that polyamide- and dyneema-based fiber phantoms provide the opportunity for verification and validation of DTI sequences on clinical scanner. Additionally, they can be applicable for testing the accuracy of fiber tracking algorithms. A strong parallel alignment of the fibers with a constant compression grade of the fiber bundles could be achieved by machine-made production. This could also provide highly reproducible diffusion properties within the anisotropic fiber phantoms. © 2008 Springer-Verlag

Study of the pd→3HeK+K−pd\to ^3\textrm{He} K^+K^- and pd→3Heϕpd\to ^3\textrm{He} \phi reactions close to threshold

Two--kaon production in proton--deuteron collisions has been studied at three energies close to threshold using a calibrated magnetic spectrograph to measure the final $^3$He and a vertex detector to measure the $K^+K^-$ pair. Differential and total cross sections are presented for the production of $\phi$--mesons, decaying through $\phi\to K^+K^-$, as well as for prompt $K^+K^-$ production. The prompt production seems to follow phase space in both its differential distributions and in its energy dependence. The amplitude for the $pd\to ^3${He}$\phi$ reaction varies little for excess energies below 22 MeV and the value is consistent with that obtained from a threshold measurement. The angular distribution of the $K^+K^-$ decay pair shows that near threshold the $\phi$--mesons are dominantly produced with polarization $m=0$ along the initial proton direction. No conclusive evidence for $f_0(980)$ production is found in the data.Comment: 13 figure

Bioelectric and biomagnetic measurements are differentially sensitive to spiral currents

Observations indicate that different information is contained in electrocardiograms and magnetocardiograms in both patients and healthy volunteers. Closed loop currents could explain this phenomenon. We hypothesized that open loops, such as the spirally shaped currents in the heart, also contribute to these differences. We modeled two types of open spiral-shaped loops, based on the heart geometry, using 12 artificial current dipoles in a physical torso phantom. The electric potentials and magnetic fields were measured simultaneously with increasing numbers of active dipoles in the spiral source geometries. We found a continuous increase in the measured amplitudes of the magnetic fields, up to a plateau value when 10 active dipoles were enabled. For the electric potentials, we found that the amplitudes increased when up to six or eight active dipoles had been enabled, and then decreased thereafter. We conclude that open loop currents also contribute to the experimentally observed differences in magnetocardiograms and electrocardiograms in both patients and healthy volunteers. Combined bioelectric and biomagnetic measurements should provide greater insight into heart activity than do single modality measurements

Strangeness Production in pp and pn Reactions at COSY

The COoler SYnchrotron COSY-J\"ulich delivers phase-space cooled, polarized proton and deuteron beams with momenta up to p=3.65 GeV/c. Various experiments on hadron-induced strangeness production on proton, neutron and nuclear targets have been carried out. Here we report about recent results on associated strangeness production in pp -> KYN (Y= Lambda,Sigma) reactions, on K^+ production in pn collisions, and on K K-bar pair production in pp interactions. We also briefly discuss possible measurements to disentangle the parity of the recently discovered pentaquark state Theta^+, the spin dependence of the YN interaction, as well as planned experiments which aim at the determination of the a_0-f_0 mixing matrix element, a quantity which is believed to be sensitive to the nature of the light scalar mesons a_0/f_0(980).Comment: 10 pages, 3 figures; Proc. VIII Int. Conf. on Hypernuclear and Strange Particle Physics, JLab, Oct. 14 - 18, 200