Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia. Produced by several different medicinal plants, berberine is a bioactive alkaloid with a wide range of pharmacological effects, including antidiabetic effects. However, it is not clear whether berberine could prevent the development of dementia in association with diabetes. Objective To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes. Search strategy Database searches A and B were conducted using PubMed and ScienceDirect. In search A, studies on berberine’s antidementia activities were identified using “berberine” and “dementia” as search terms. In search B, recent studies on berberine’s effects on diabetes were surveyed using “berberine” and “diabetes” as search terms. Inclusion criteria Clinical and preclinical studies that investigated berberine’s effects associated with MetS and cognitive dysfunction were included. Data extraction and analysis Data from studies were extracted by one author, and checked by a second; quality assessments were performed independently by two authors. Results In search A, 61 articles were identified, and 22 original research articles were selected. In search B, 458 articles were identified, of which 101 were deemed relevant and selected. Three duplicates were removed, and a total of 120 articles were reviewed for this study. The results demonstrate that berberine exerts beneficial effects directly in the brain: enhancing cholinergic neurotransmission, improving cerebral blood flow, protecting neurons from inflammation, limiting hyperphosphorylation of tau and facilitating β-amyloid peptide clearance. In addition, evidence is growing that berberine is effective against diabetes and associated disorders, such as atherosclerosis, cardiomyopathy, hypertension, hepatic steatosis, diabetic nephropathy, gut dysbiosis, retinopathy and neuropathy, suggesting indirect benefits for the prevention of dementia. Conclusion Berberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS

Not throwing out the baby with the bathwater: Bell's condition of local causality mathematically 'sharp and clean'

The starting point of the present paper is Bell's notion of local causality and his own sharpening of it so as to provide for mathematical formalisation. Starting with Norsen's (2007, 2009) analysis of this formalisation, it is subjected to a critique that reveals two crucial aspects that have so far not been properly taken into account. These are (i) the correct understanding of the notions of sufficiency, completeness and redundancy involved; and (ii) the fact that the apparatus settings and measurement outcomes have very different theoretical roles in the candidate theories under study. Both aspects are not adequately incorporated in the standard formalisation, and we will therefore do so. The upshot of our analysis is a more detailed, sharp and clean mathematical expression of the condition of local causality. A preliminary analysis of the repercussions of our proposal shows that it is able to locate exactly where and how the notions of locality and causality are involved in formalising Bell's condition of local causality.Comment: 14 pages. To be published in PSE volume "Explanation, Prediction, and Confirmation", edited by Dieks, et a

A new test of conservation laws and Lorentz invariance in relativistic gravity

General relativity predicts that energy and momentum conservation laws hold and that preferred frames do not exist. The parametrised post-Newtonian formalism (PPN) phenomenologically quantifies possible deviations from general relativity. The PPN parameter alpha_3 (which identically vanishes in general relativity) plays a dual role in that it is associated both with a violation of the momentum conservation law, and with the existence of a preferred frame. By considering the effects of alpha_3 neq 0 in certain binary pulsar systems, it is shown that alpha_3 < 2.2 x 10^-20 (90% CL). This limit improves on previous results by several orders of magnitude, and shows that pulsar tests of alpha_3 rank (together with Hughes-Drever-type tests of local Lorentz invariance) among the most precise null experiments of physics.Comment: Submitted to Classical Quantum Gravity, LaTeX, requires ioplppt.sty, no figure

Toward a Deterministic Model of Planetary Formation IV: Effects of Type-I Migration

In a further development of a deterministic planet-formation model (Ida & Lin 2004), we consider the effect of type-I migration of protoplanetary embryos due to their tidal interaction with their nascent disks. During the early embedded phase of protostellar disks, although embryos rapidly emerge in regions interior to the ice line, uninhibited type-I migration leads to their efficient self-clearing. But, embryos continue to form from residual planetesimals at increasingly large radii, repeatedly migrate inward, and provide a main channel of heavy element accretion onto their host stars. During the advanced stages of disk evolution (a few Myr), the gas surface density declines to values comparable to or smaller than that of the minimum mass nebula model and type-I migration is no longer an effective disruption mechanism for mars-mass embryos. Over wide ranges of initial disk surface densities and type-I migration efficiency, the surviving population of embryos interior to the ice line has a total mass several times that of the Earth. With this reservoir, there is an adequate inventory of residual embryos to subsequently assemble into rocky planets similar to those around the Sun. But, the onset of efficient gas accretion requires the emergence and retention of cores, more massive than a few M_earth, prior to the severe depletion of the disk gas. The formation probability of gas giant planets and hence the predicted mass and semimajor axis distributions of extrasolar gas giants are sensitively determined by the strength of type-I migration. We suggest that the observed fraction of solar-type stars with gas giant planets can be reproduced only if the actual type-I migration time scale is an order of magnitude longer than that deduced from linear theories.Comment: 32 pages, 8 figures, 1 table, accepted for publication in Ap

Electromagnetic Magic: The Relativistically Rotating Disk

A closed form analytic solution is found for the electromagnetic field of the charged uniformly rotating conducting disk for all values of the tip speed $v$ up to $c$. For $v=c$ it becomes the Magic field of the Kerr-Newman black hole with $G$ set to zero. The field energy, field angular momentum and gyromagnetic ratio are calculated and compared with those of the electron. A new mathematical expression that sums products of 3 Legendre functions each of a different argument, is demonstrated.Comment: 10 pages, one figur

Ensemble inequivalence, bicritical points and azeotropy for generalized Fofonoff flows

We present a theoretical description for the equilibrium states of a large class of models of two-dimensional and geophysical flows, in arbitrary domains. We account for the existence of ensemble inequivalence and negative specific heat in those models, for the first time using explicit computations. We give exact theoretical computation of a criteria to determine phase transition location and type. Strikingly, this criteria does not depend on the model, but only on the domain geometry. We report the first example of bicritical points and second order azeotropy in the context of systems with long range interactions.Comment: 4 pages, submitted to Phys. Rev. Let

Non-local two-photon correlations using interferometers physically separated by 35 meters

An experimental demonstration of quantum correlations is presented. Energy and time entangled photons at wavelengths of 704 and 1310 nm are produced by parametric downconversion in KNbO3 and are sent through optical fibers into a bulk-optical (704 nm) and an all-fiber Michelson-interferometer (1310 nm), respectively. The two interferometers are located 35 meters aside from one another. Using Faraday-mirrors in the fiber-interferometer, all birefringence effects in the fibers are automatically compensated. We obtained two-photon fringe visibilities of up to 95 % from which one can project a violation of Bell's inequality by 8 standard deviations. The good performance and the auto-aligning feature of Faraday-mirror interferometers show their potential for a future test of Bell's inequalities in order to examine quantum-correlations over long distances.Comment: 9 pages including 3 postscript figures, to be published in Europhys. Let

Atom-photon, atom-atom and photon-photon entanglement preparation via fractional adiabatic passage

We propose a relatively robust scheme to generate maximally entangled states of (i) an atom and a cavity photon, (ii) two atoms in their ground states, and (iii) two photons in two spatially separate high-Q cavities. It is based on the interaction via fractional adiabatic passage of a three-level atom traveling through a cavity mode and a laser beam. The presence of optical phases is emphasized.Comment: 6 pages, 7 figures. We have changed the title, the abstract and the text. The references have been updated. (Accepted by Phys. Rev. A

A Bell-type test of energy-time entangled qutrits

We have performed a Bell-type test for energy-time entangled qutrits. A method of inferring the Bell violation in terms of an associated interference visibility is derived. Using this scheme we obtained a Bell value of $2.784 \pm 0.023$, representing a violation of $34 \sigma$ above the limit for local variables. The scheme has been developed for use at telecom wavelengths and using proven long distance quantum communication architecture to optimize the utility of this high dimensional entanglement resource.Comment: replaced lost acknowledement