Prognostic impact of Ki-67 proliferative index in resectable pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by complex biological features and poor prognosis. A prognostic stratification of PDAC would help to improve patient management. The aim of this study was to analyse the expression of Ki-67 in relation to prognosis in a cohort of patients with PDAC who had surgical treatment

The ionizing photon production efficiency of bright z∼\sim2-5 galaxies

We investigate the production efficiency of ionizing photons ($\xi_{ion}^*$) of 1174 galaxies with secure redshift at z=2-5 from the VANDELS survey to determine the relation between ionizing emission and physical properties of bright and massive sources. We constrain $\xi_{ion}^*$ and galaxy physical parameters by means of spectro-photometric fits performed with the BEAGLE code. The analysis exploits the multi-band photometry in the VANDELS fields, and the measurement of UV rest-frame emission lines (CIII]$\lambda 1909$, HeII$\lambda 1640$, OIII]$\lambda 1666$) from deep VIMOS spectra. We find no clear evolution of $\xi_{ion}^*$ with redshift within the probed range. The ionizing efficiency slightly increases at fainter $M_{UV}$, and bluer UV slopes, but these trends are less evident when restricting the analysis to a complete subsample at log(M$_{star}$/M$_{\odot}$)$>$9.5. We find a significant trend of increasing $\xi_{ion}^*$ with increasing EW(Ly$\alpha$), with an average log($\xi_{ion}^*$/Hz erg$^{-1}$)$>$25 at EW$>$50\AA, and a higher ionizing efficiency for high-EW CIII]$\lambda 1909$ and OIII]$\lambda 1666$ emitters. The most significant correlations are found with respect to stellar mass, specific star-formation rate (sSFR) and SFR surface density ($\Sigma_{SFR}$). The relation between $\xi_{ion}^*$ and sSFR shows a monotonic increase from log($\xi_{ion}^*$/Hz erg$^{-1}$) $\sim$24.5 at log(sSFR)$\sim$-9.5$yr^{-1}$ to $\sim$25.5 at log(sSFR)$\sim$-7.5$yr^{-1}$, a low scatter and little dependence on mass. The objects above the main-sequence of star-formation consistently have higher-than-average $\xi_{ion}^*$. A clear increase of $\xi_{ion}^*$ with $\Sigma_{SFR}$ is also found, with log($\xi_{ion}^*$/Hz erg$^{-1}$)$>$25 for objects at $\Sigma_{SFR}>$10 M$_{\odot}/yr/kpc^2$.(Abridged)Comment: 11 pages, 9 figures, accepted for publication in A&

Early Results from GLASS-JWST. XIX: A High Density of Bright Galaxies at z≈10z\approx10 in the Abell 2744 Region

We report the detection of a high density of redshift $z\approx 10$ galaxies behind the foreground cluster Abell 2744, selected from imaging data obtained recently with NIRCam onboard {\it JWST} by three programs -- GLASS-JWST, UNCOVER, and DDT\#2756. To ensure robust estimates of the lensing magnification $\mu$, we use an improved version of our model that exploits the first epoch of NIRCam images and newly obtained MUSE spectra, and avoids regions with $\mu>5$ where the uncertainty may be higher. We detect seven bright $z\approx 10$ galaxies with demagnified rest-frame $-22 \lesssim M_{\rm UV}\lesssim -19$ mag, over an area of $\sim37$ sq. arcmin. Taking into account photometric incompleteness and the effects of lensing on luminosity and cosmological volume, we find that the density of $z\approx 10$ galaxies in the field is about $10\times$ ($3\times$) larger than the average at $M_{UV}\approx -21~ (-20)$ mag reported so far. The density is even higher when considering only the GLASS-JWST data, which are the deepest and the least affected by magnification and incompleteness. The GLASS-JWST field contains 5 out of 7 galaxies, distributed along an apparent filamentary structure of 2 Mpc in projected length, and includes a close pair of candidates with $M_{\rm UV}< -20$ mag having a projected separation of only 16 kpc. These findings suggest the presence of a $z\approx 10$ overdensity in the field. In addition to providing excellent targets for efficient spectroscopic follow-up observations, our study confirms the high density of bright galaxies observed in early {\it JWST} observations, but calls for multiple surveys along independent lines of sight to achieve an unbiased estimate of their average density and a first estimate of their clustering.Comment: Accepted for publication in ApJL, 13 pages, 4 figure

Non-AIDS defining cancers in the D:A:D Study-time trends and predictors of survival : a cohort study

BACKGROUND:Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.METHODS:Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.RESULTS:Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.CONCLUSIONS:The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC

Progetto “archeologia urbana a Senigallia” II: le ricerche di via Baroccio e di via Gherardi

Il contributo fa conoscere due importanti nuovi siti nell'ambito del centro storico di Senigallia: il primo (Via Baroccio) ha restituito un antico santuario repubblicano defli inizi del III sec. a.C., mentre il secondo (Via Gherardi) i resti di un'abitazione repubblicana (III-II sec. a.C.

Rapporto di previsione

Consiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Archeologia Urbana a Senigallia. II. Le ricerche di Via Baroccio e di Via Gherardi

Il contributo fa conoscere due importanti nuovi siti nell'ambito del centro storico di Senigallia: il primo (Via Baroccio) ha restituito un antico santuario repubblicano defli inizi del III sec. a.C., mentre il secondo (Via Gherardi) i resti di un'abitazione repubblicana (III-II sec. a.C.

Archeologia urbana a Senigallia III: i nuovi dati dall’area archeologica “La Fenice”

Il contributo rende merito delle recenti ricerche condotte all'interno dell'area archeologica "La Fenice" di Senigallia, soprattutto in seguito a sondaggi stratigrafici e carotaggi a mano