Thrombose et sténoses artérielles digestives du sujet jeune

INTRODUCTION: L'ischémie mésentrique est une pathologie fréquente du sujet âgé, en rapport avec une arthérosclérose ou un trouble du rythme cardiaque responsable d'embolie. OBJECTIF: décrire les présentations cliniques, les étiologies et l'évolution des thromboses et sténoses des artères digestives chez le sujet jeune. METHODES: Etude rétrospective descriptive unicentrique des données cliniques et radiologiques des patients de moins de 60 ans suivis entre 1998 et 2013 dans les services de chirurgie vasculaire et de médecine interne pour thrombose ou sténose des artères digestives. Les dossier répondant au codage ischémie digestive ont été sélectionné par le département mircrocirculation digestive sont exclus de l'étude. Les objectifs principaux visaient à établir les circonstances diagnostiques, les étiologies et le devenir des patients avec atteintes artérielles digestives. Les objectifs secondaires étaient de déterminer la fréquence des facteur de risque cardio-vasculaires et d'athérosclérose précoce. Une étude comparative des étiologies et de la mortalité en fonction de l'âge et en fonction de la présentation des symptômes a été effectuée à l'aide du test exact de Fisher. RESULTATS: Sur 186 dossiers, nous avons retenu 29 patients (16 femmes, 13 hommes) d'âge moyen 42,6 ans (15-59 ans). Onze patients (38%) avaient des symptômes d'ischémie mésentérique chronique, sept des symptômes chroniques en acutisation (24%), sept des symptômes d'ischémie mésentérique aiguë (24%), quatre étaient asymptomatiques (14%) [ ]AIX-MARSEILLE2-BU Méd/Odontol. (130552103) / SudocSudocFranceF

Acute pancreatitis and pneumonia due to Mycoplasma pneumoniae: a case report

Mycoplasma pneumoniae is a bacterium responsible for 15 to 40 % of acute community-acquired pneumonia in children and 20 % of adult cases. Several extrapulmonary manifestations have been reported. We report a rare case of an adult patient suffering from pneumonia associated with an acute pancreatitis in the setting of Mycoplasma pneumoniae infection

Pulmonary embolism induced by methotrexate in a dermatomyositis patient

International audienc

Atrophy of the vocal fold: An usual cause of hoarseness in scleroderma.

International audienceno abstrac

Impaired Granuloma Formation in Sepsis: Impact of Monocytopenia.

Granulomas are a collection of immune cells considered to be protective in infectious diseases. The in vitro generation of granulomas is an interesting substitution to invasive approaches of granuloma study. The monitoring of immune response through the determination of in vitro granuloma formation in patients with severe sepsis may be critical to individualize treatments. We compared the in vitro generation of granulomas by co-culturing circulating mononuclear cells from 19 patients with severe sepsis, 9 patients cured from Q fever and 12 healthy subjects as controls, and Sepharose beads coated either with BCG or Coxiella burnetii extracts to analyze both immune and innate granulomas, respectively. We showed that the great majority of patients with severe sepsis were unable to form granulomas in response to BCG and C. burnetii extracts whereas more than 80% of healthy controls and patients cured from Q fever formed granulomas. We also found that monocytopenia and defective production of tumor necrosis factor were associated with reduced formation of granulomas in patients with severe sepsis even if TNF did not seem to be involved in the defective granuloma formation. Taken together, these results suggest that the deficiency of granuloma formation may be a measurement of altered recruitment and activation of monocytes and lymphocytes in patients with severe sepsis

Cerebral pseudotumor as the first manifestation of POEMS syndrome: A case report

International audienc

Granuloma formation according to lymphopenia or monocytopenia.

<p>Granuloma formation with BCG-coated beads (left) and CB-coated beads (right) was measured during 9 days in PBMCs from patients with severe sepsis. Patients were classified according to lymphopenia (A) and monocytopenia (B). The results are expressed as the percentage of beads entirely covered by PBMCs. The boxplots represent the medians with the first and third quartiles. The whiskers represent the highest value that is within 1.5*IQR. Data beyond the end of the whiskers are outliers and plotted as black points. * p < 0.05 represents the differences between patients with and without monocytopenia.</p

Patient features.

<p>Patient features.</p

Non HCV-related infectious cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey and systematic review of the literature

International audienc