Ecology of a reef forming serpulid, Hydroides norvegica : final report

Experimental results reported herein were obtained on colonies of serpulid worms collected from a filter box (Fig. 1) through which water was pumped at a rate of about 1,000 gallons per day. The filter box was located within and the water was drawn from the cooling water intake system of the Central Power and Light Company plant located between the Port of Corpus Christi and Nueces Bay, Texas. Although at least three species of serpulids were identified from this locality during the spring of 1969, all specimens collected for experimentation included only Hydroides norvegica. Salinity of the water in the Port of Corpus Christi ranged from 29 to 35 ppt through the sampling period.Marine Scienc

Environmental Considerations in Naval Operations

With its historic mission clearly defined as supporting the operational fleet, the Oceanographic Office of the U.S. Navy in recent years has expanded its efforts to also meet the growing challenge of working within a national program of studying the marine environment

Beach impact study, Padre Island National Seashore

Prepared for Office of Natural Science, Southwest Region, National Park Service, under contract CX70005044830 April 1976Vegetative differences between heavily and very lightly trafficked beaches show that more beach traffic correlates with quantitative decreases in variety and density of plants and with declines of grasses relative to forbs. The vegetated portions of all beaches continue to grow in volume. However, this is at the expense of the more seaward (more trafficked) parts of the beaches and has lead to overall loss of total beach volume except where vehicular traffic is prohibited. The very lightly trafficked beach is the only study site wherein the entire beach to mean sea level has grown. The effect of these trends on resistance to storm surge erosion remains to be tested.Marine Scienc

Beach impact study, Padre Island National Seashore

The purpose of this study is to determine if the rapidly increasing vehicular and pedestrian traffic on the beaches of the Padre Island National Seashore is adversely affecting the long term stability of the vegetated foredune system. At each of the four study sites a pair of concrete and steel monuments was erected along a range line perpendicular to the local shoreline. This enables the survey crew to measure exactly the same profile line during each survey in order to accurately measure small amounts of erosion or accretion. During each survey, elevations are determined every 10 feet along the range line. A level loop including the stations at NOTRAF, PEDTRAF, and VEHTRAF has been closed so that those three stations are all relative to the same datum. The datum is approximately mean sea level as determined from local water level and a tide gage located at the Corpus Christi Water Exchange Pass. The datum for SHELL is also approximately mean sea level and was determined in the same fashion, but was not tied in to the other three stations by a level loop because of the distance involved. The study areas were profiled monthly from April 1974 through July 1974 and bimonthly thereafter. During the fall and winter study periods, qualitative vegetative data was collected at each of the four study sites during each survey. The species present in each zone of each study area were noted as well as their effectiveness in sand stabilization and trapping. During November 1974 detailed maps of the vegetation at NOTRAF and VEHTRAF were compiled in order to better understand the function of each species in sand stabilization. A similar map was compiled in SHELL during December. These maps are representative of the individual localities and broadly representative of each traffic usage level for the fall and early winter months.Marine Scienc

Heterogeneous Agglomeration

Many prior treatments of agglomeration explicitly or implicitly assume that all industries agglomerate for the same reasons. This paper uses U.K. establishment-level coagglomeration data to document substantial heterogeneity across industries in the microfoundations of agglomeration economies. It finds robust evidence of organizational and adaptive agglomeration forces as discussed by Chinitz (1961), Vernon (1960), and Jacobs (1969). These forces interact with the traditional Marshallian (1890) factors of input sharing, labor pooling, and knowledge spillovers, establishing a previously unrecognized complementarity between the approaches of Marshall and Jacobs, as well as others, to the analysis of agglomeration

Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis

BACKGROUND. Baseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinical response to RTX in granulomatosis with polyangiitis (CPA) and microscopic polyangiitis (MPA). METHODS. A previously validated quantitative PCR-based (qPCR-based) platform was used to assess FCRL5 expression in patients with GPA/MPA (RAVE trial, NCT00104299). RESULTS. Baseline FCRL5 expression was significantly higher in patients achieving complete remission (CR) at 6,12, and 18 months, independent of other clinical and serological variables, among those randomized to RTX but not cyclophosphamide-azathioprine (CYC/AZA). Patients with baseline FCRL5 expression >= 0.01 expression units (termed FCRL5(hi)) exhibited significantly higher CR rates at 6,12, and 18 months as compared with FCRL5(lo) subjects (84% versus 57% [P = 0.016], 68% versus 40% [P = 0.02], and 68% versus 29% [P = 0.0009], respectively). CONCLUSION. Our data taken together suggest that FCRL5 is a biomarker of B cell lineage associated with increased achievement and maintenance of complete remission among patients treated with RTX and warrant further investigation in a prospective manner

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis

Measurement of inclusive D*+- and associated dijet cross sections in photoproduction at HERA

Inclusive photoproduction of D*+- mesons has been measured for photon-proton centre-of-mass energies in the range 130 < W < 280 GeV and a photon virtuality Q^2 < 1 GeV^2. The data sample used corresponds to an integrated luminosity of 37 pb^-1. Total and differential cross sections as functions of the D* transverse momentum and pseudorapidity are presented in restricted kinematical regions and the data are compared with next-to-leading order (NLO) perturbative QCD calculations using the "massive charm" and "massless charm" schemes. The measured cross sections are generally above the NLO calculations, in particular in the forward (proton) direction. The large data sample also allows the study of dijet production associated with charm. A significant resolved as well as a direct photon component contribute to the cross section. Leading order QCD Monte Carlo calculations indicate that the resolved contribution arises from a significant charm component in the photon. A massive charm NLO parton level calculation yields lower cross sections compared to the measured results in a kinematic region where the resolved photon contribution is significant.Comment: 32 pages including 6 figure

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors