449 research outputs found
Quantum Phase Transition of Randomly-Diluted Heisenberg Antiferromagnet on a Square Lattice
Ground-state magnetic properties of the diluted Heisenberg antiferromagnet on
a square lattice are investigated by means of the quantum Monte Carlo method
with the continuous-time loop algorithm. It is found that the critical
concentration of magnetic sites is independent of the spin size S, and equal to
the two-dimensional percolation threshold. However, the existence of quantum
fluctuations makes the critical exponents deviate from those of the classical
percolation transition. Furthermore, we found that the transition is not
universal, i.e., the critical exponents significantly depend on S.Comment: RevTeX, 4 pages including 5 EPS figure
Classical Correlation-Length Exponent in Non-Universal Quantum Phase Transition of Diluted Heisenberg Antiferromagnet
Critical behavior of the quantum phase transition of a site-diluted
Heisenberg antiferromagnet on a square lattice is investigated by means of the
quantum Monte Carlo simulation with the continuous-imaginary-time loop
algorithm. Although the staggered spin correlation function decays in a power
law with the exponent definitely depending on the spin size , the
correlation-length exponent is classical, i.e., . This implies that
the length scale characterizing the non-universal quantum phase transition is
nothing but the mean size of connected spin clusters.Comment: 4 pages, 3 figure
Archaeobotanical investigations in the Aisne valley, northern France, from the neolithic up to the early Middle Ages
Testosterone treatment is not associated with increased risk of adverse cardiovascular events: results from the Registry of Hypogonadism in Men (RHYME).
SummaryAims The aim of this study was to assess cardiovascular (CV) safety of testosterone replacement therapy (TRT) in a large, diverse cohort of European men with hypogonadism (HG). Methods The Registry of Hypogonadism in Men (RHYME) was designed as a multi-national, longitudinal disease registry of men diagnosed with hypogonadism (HG) at 25 clinical sites in six European countries. Data collection included a complete medical history, physical examination, blood sampling and patient questionnaires at multiple study visits over 2â3 years. Independent adjudication was performed on all mortalities and CV outcomes. Results Of 999 patients enrolled with clinically diagnosed HG, 750 (75%) initiated some form of TRT. Registry participants, including both treated and untreated patients, contributed 23 900 person-months (99.6% of the targeted) follow-up time. A total of 55 reported CV events occurred in 41 patients. Overall, five patients died of CV-related causes (3 on TRT, 2 untreated) and none of the deaths were adjudicated as treatment-related. The overall CV incidence rate was 1522 per 100 000 person-years. CV event rates for men receiving TRT were not statistically different from untreated men (P=.70). Regardless of treatment assignment, CV event rates were higher in older men and in those with increased CV risk factors or a prior history of CV events. Conclusions Age and prior CV history, not TRT use, were predictors of new-onset CV events in this multi-national, prospective hypogonadism registry
Testosterone treatment is not associated with increased risk of prostate cancer or worsening of lower urinary tract symptoms: prostate health outcomes in the Registry of Hypogonadism in Men
The Medicine Tree: Unsettling palaeoecological perceptions of past environments and human activity
In this paper, we consider palaeoecological approaches to past landscapes and reflect upon how these are relevant to archaeological themes concerning concepts of environmental change and the role of past and present human communities in these processes. In particular, we highlight the importance of local context in the perception and understanding of landscape. Utilising a case study from Nepal, we look to âunsettleâ a conventional palaeoecological interpretation of a pollen record, originally constructed on western ecological principles, and instead draw on an interpretative perspective rooted in local Buddhist ecological knowledge, or a âfolk taxonomyâ, known as âThe Medicine Treeâ. We discuss how the interpretations of patterns and processes of vegetation change from a pollen record are not necessarily absolute. In particular, we outline how the palaeoecological frame of enquiry and reference is rooted in an essentially Eurocentric, Western scientific paradigm, which, in turn, shapes how we perceive and conceive of past landscapes and the role of âanthropogenic impactâ on vegetation. The aim of this is not to suggest that scientific approaches to the âreconstructionâ of past landscapes are necessarily invalid, but to illustrate how âempiricalâ scientific methods and interpretations in archaeological science are contingent upon specific social and cultural frames of reference. We discuss the broader relevance of this, such as how we interpret past human activity and perception of landscape change, the ways in which we might look to mobilise research in the context of contemporary problems, issues concerning âdegraded landscapesâ and how we incorporate local and archaeological perspectives with palaeoecology within an interconnected and iterative process
Rare region effects at classical, quantum, and non-equilibrium phase transitions
Rare regions, i.e., rare large spatial disorder fluctuations, can
dramatically change the properties of a phase transition in a quenched
disordered system. In generic classical equilibrium systems, they lead to an
essential singularity, the so-called Griffiths singularity, of the free energy
in the vicinity of the phase transition. Stronger effects can be observed at
zero-temperature quantum phase transitions, at nonequilibrium phase
transitions, and in systems with correlated disorder. In some cases, rare
regions can actually completely destroy the sharp phase transition by smearing.
This topical review presents a unifying framework for rare region effects at
weakly disordered classical, quantum, and nonequilibrium phase transitions
based on the effective dimensionality of the rare regions. Explicit examples
include disordered classical Ising and Heisenberg models, insulating and
metallic random quantum magnets, and the disordered contact process.Comment: Topical review, 68 pages, 14 figures, final version as publishe
Red wine and components flavonoids inhibit UGT2B17 in vitro
Background
The metabolism and excretion of the anabolic steroid testosterone occurs by glucuronidation to the conjugate testosterone glucuronide which is then excreted in urine. Alterations in UGT glucuronidation enzyme activity could alter the rate of testosterone excretion and thus its bioavailability. The aim of this study is to investigate if red wine, a common dietary substance, has an inhibitory effect on UGT2B17.
Methods
Testosterone glucuronidation was assayed using human UGT2B17 supersomes with quantification of unglucuronidated testosterone over time using HPLC with DAD detection. The selected red wine was analysed using HPLC and the inhibitory effects of the wine and phenolic components were tested independently in a screening assay. Further analyses were conducted for the strongest inhibitors at physiologically relevant concentrations. Control experiments were conducted to determine the effects of the ethanol on UGT2B17.
Results
Over the concentration range of 2 to 8% the red wine sample inhibited the glucuronidation of testosterone by up to 70% over 2 hours. The ethanol content had no significant effect. Three red wine phenolics, identified by HLPC analyses, also inhibited the enzyme by varying amounts in the order of quercetin (72%), caffeic acid (22%) and gallic acid (9%); using a ratio of phenolic:testosterone of 1:2.5. In contrast p-coumaric acid and chlorogenic acid had no effect on the UGT2B17. The most active phenolic was selected for a detailed study at physiologically relevant concentrations, and quercetin maintained inhibitory activity of 20% at 2 M despite a ten-fold excess of testosterone.
Conclusion
This study reports that in an in vitro supersome-based assay, the key steroid-metabolising enzyme UGT2B17 is inhibited by a number of phenolic dietary substances and therefore may reduce the rate of testosterone glucuronidation in vivo. These results highlight the potential interactions of a number of common dietary compounds on testosterone metabolism. Considering the variety of foodstuffs that contain flavonoids, it is feasible that diet can elevate levels of circulating testosterone through reduction in urinary excretion. These results warrant further investigation and extension to a human trial to delineate the healt
Palaeo-ecological and archaeological analysis of two Dutch Celtic fields (Zeijen-Noordse Veld and Wekerom-Lunteren): solving the puzzle of local Celtic field bank formation
Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells
authorHypoxia inducible factor-1 (HIF-1) is considered a crucial mediator of the cellular response to hypoxia through its regulation of genes that control angiogenesis^1, ^2, ^3, ^4. It represents an attractive therapeutic target^5, ^6 in colon cancer, one of the few tumor types that shows a clinical response to antiangiogenic therapy^7. But it is unclear whether inhibition of HIF-1 alone is sufficient to block tumor angiogenesis^8, ^9. In HIF-1_α knockdown DLD-1 colon cancer cells (DLD-1^HIF-kd), the hypoxic induction of vascular endothelial growth factor (VEGF) was only partially blocked. Xenografts remained highly vascularized with microvessel densities identical to DLD-1 tumors that had wild-type HIF-1_α (DLD-1^HIF-wt). In addition to the preserved expression of VEGF, the proangiogenic cytokine interleukin (IL)-8 was induced by hypoxia in DLD-1^HIF-kd but not DLD-1^HIF-wt cells. This induction was mediated by the production of hydrogen peroxide and subsequent activation of NF-_KB. Furthermore, the KRAS oncogene, which is commonly mutated in colon cancer, enhanced the hypoxic induction of IL-8. A neutralizing antibody to IL-8 substantially inhibited angiogenesis and tumor growth in DLD-1^HIF-kd but not DLD-1^HIF-wt xenografts, verifying the functional significance of this IL-8 response. Thus, compensatory pathways can be activated to preserve the tumor angiogenic response, and strategies that inhibit HIF-1α may be most effective when IL-8 is simultaneously targeted
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