6,790 research outputs found

    Effects of hemodialysis on circulating adrenomedullin concentrations in patients with end-stage renal disease

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    To characterize the determinants of circulating levels of adrenomedullin (AM), the plasma levels of this peptide were measured in 58 patients with end-stage renal disease on hemodialysis, Predialysis plasma levels of AM were more than twice as high in patients on hemodialysis as compared to controls. In hemodialysis patients with heart failure (NYHA classes II-IV) or hypertensive HD patients plasma levels of AM were significantly higher than in patients with end-stage renal disease only. Plasma levels of AM were clot altered immediately by hemodialysis but decreased significantly 14-20 h after hemodialysis, AM plasma levels before hemodialysis and 14-20 h after hemodialysis were correlated with the corresponding mean arterial pressure

    Heat Capacity study of β\beta-FeSi2_2 single crystals

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    Heat Capacity of needle-like [length=5mm, diameter=1 mm] β\beta-FeSi2_{2} single crystal, grown by chemical vapor transport has been measured. Two anomalies are found, a broad deviation centered around 160 K and a clear deviation at a temperature of 255 K approximately. We have attempted to relate these to the anomalies previously reported in the case of the resistivity data. The Transient Thermoelectric Effect [TTE] results lead us to the inference that the system under goes from single carrier system to at least two carrier system at 220 K-our heat capacity results seem to provide further independent evidence for this transition in this system.Comment: 8 pages, 5 figure

    Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.

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    While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disease. Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. To this end, we conducted a patient study to determine whether HCC can be resolved using 68Ga-citrate positron emission tomography (PET). One patient with recurrent HCC was injected with 300 MBq of 68Ga-citrate and imaged with PET/CT 249 minutes post injection. Four (28%) of 14 hepatic lesions were avid for 68Ga-citrate. One extrahepatic lesion was not PET avid. The average maximum standardized uptake value (SUVmax) for the lesions was 7.2 (range: 6.2-8.4), while the SUVmax of the normal liver parenchyma was 4.7 and blood pool was 5.7. The avid lesions were not significantly larger than the quiescent lesions, and a prior contrast CT showed uniform enhancement among the lesions, suggesting that tumor signals are due to specific binding of the radiotracer to the transferrin receptor, rather than enhanced vascularity in the tumor microenvironment. Further studies are required in a larger patient cohort to verify the molecular basis of radiotracer uptake and the clinical utility of this tool

    Damping of dHvA oscillations and vortex-lattice disorder in the peak-effect region of strong type-II superconductors

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    The phenomenon of magnetic quantum oscillations in the superconducting state poses several questions that still defy satisfactory answers. A key controversial issue concerns the additional damping observed in the vortex state. Here, we show results of \mu SR, dHvA, and SQUID magnetization measurements on borocarbide superconductors, indicating that a sharp drop observed in the dHvA amplitude just below H_{c2} is correlated with enhanced disorder of the vortex lattice in the peak-effect region, which significantly enhances quasiparticle scattering by the pair potential.Comment: 4 pages 4 figure

    Formation of metallic magnetic clusters in a Kondo-lattice metal: Evidence from an optical study

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    Magnetic materials are usually divided into two classes: those with localised magnetic moments, and those with itinerant charge carriers. We present a comprehensive experimental (spectroscopic ellipsomerty) and theoretical study to demonstrate that these two types of magnetism do not only coexist but complement each other in the Kondo-lattice metal, Tb2PdSi3. In this material the itinerant charge carriers interact with large localised magnetic moments of Tb(4f) states, forming complex magnetic lattices at low temperatures, which we associate with self-organisation of magnetic clusters. The formation of magnetic clusters results in low-energy optical spectral weight shifts, which correspond to opening of the pseudogap in the conduction band of the itinerant charge carriers and development of the low- and high-spin intersite electronic transitions. This phenomenon, driven by self-trapping of electrons by magnetic fluctuations, could be common in correlated metals, including besides Kondo-lattice metals, Fe-based and cuprate superconductors.Comment: 30 pages, 6 Figure

    A new strategy for finite element computations involving moving boundaries and interfaces-The deforming-spatial-domain/space-time procedure: II. Computation of free-surface flows, two-liquid flows, and flows with drifting cylinders

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    New finite element computational strategies for free-surface flows, two-liquid flows, and flows with drifting cylinders are presented. These strategies are based on the deforming spatial-domain/spacetime (DSD/ST) procedure. In the DSD/ST approach, the stabilized variational formulations for these types of flow problem are written over their space-time domains. One of the important features of the approach is that it enables one to circumvent the difficulty involved in remeshing every time step and thus reduces the projection errors introduced by such frequent remeshings. Computations are performed for various test problems mainly for the purpose of demonstrating the computational capability developed for this class of problems. In some of the test cases, such as the liquid drop problem, surface tension is taken into account. For flows involving drifting cylinders, the mesh moving and remeshing schemes proposed are convenient and reduce the frequency of remeshing

    Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer.

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    BackgroundPET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with 68Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 Â± 12.9 ng/ml, and mean PSA doubling time was 7.1 Â± 6.6 months. Detection rates of anatomic correlates for prostate-specific membrane antigen (PSMA)-positive foci were evaluated on small field of view (FOV) T2, T1 post-contrast, and diffusion-weighted images. For prostate bed recurrences, the detection rate of dynamic contrast-enhanced (DCE) imaging for PSMA-positive foci was evaluated. Finally, the detection sensitivity for PSMA-avid foci on 3- and 8-min PET acquisitions was compared.ResultsPSMA-positive foci were detected in 89.1% (49/55) of patients evaluated. Small FOV T2 performed best for lymph nodes and detected correlates for all PSMA-avid lymph nodes. DCE imaging performed the best for suspected prostate bed recurrence, detecting correlates for 87.5% (14/16) of PSMA-positive prostate bed foci. The 8-min PET acquisition performed better than the 3-min acquisition for lymph nodes smaller than 1 cm, detecting 100% (57/57) of lymph nodes less than 1 cm, compared to 78.9% (45/57) for the 3-min acquisition.ConclusionPSMA PET/MRI performed well for the detection of sites of suspected recurrent disease in patients with BCR. Of the MRI sequences obtained for localization, small FOV T2 images detected the greatest proportion of PSMA-positive abdominopelvic lymph nodes and DCE imaging detected the greatest proportion of PSMA-positive prostate bed foci. The 8-min PET acquisition was superior to the 3 min acquisition for detection of small lymph nodes
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