W, Z and photon production in CMS

The production of electroweak bosons (photons, W and Z particles) in PbPb and pp collisions at sqrt(s) = 2.76 TeV per interacting nucleon pair has been measured with the CMS detector at the LHC. Direct photon production is studied using samples of isolated photons. W and Z bosons are reconstructed through their leptonic decay into muons. Their production rate in PbPb data is studied as a function of the centrality of the collision and compared to that in pp interactions, once normalized by the number of binary nucleon-nucleon interactions. The results are also compared to next-to-leading-order perturbative QCD calculations.Comment: Proceedings from Plenary Talk at 5th International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions (Hard Probes 2012) at Cagliari (Italia

Diagnostic criteria in proliferative verrucous leukoplakia: evaluation

Objectives: to evaluate the ability of the diagnostic criteria proposed by Cerero et al in 2010 to perform an early diagnose in patients with proliferative verrucous leukoplakia. Study Design: retrospective study with patients diagnosed with leukoplakia at Oral Medicine Service at Oral Medicine and Surgery Department at Dentistry Faculty at Universidad Complutense of Madrid. Results: the criteria were applied in 116 patients, turning positive in 40 cases. Out of these, 24 (60%) had been previously diagnosed with PVL. Most frequent criteria were major criteria A and E, concerning lesion's site and histopathology, and minor criteria b and c, concerning sex and smoking habit. Conclusions: diagnostic criteria developed by Cerero et al can be a useful tool for an early diagnose of PVL, as in 60% of the cases, the criteria would have allowed to make an early diagnose of the disease

Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embaràs; Infecció asimptomàticaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embarazo; Infección asintomáticaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pregnancy; Asymptomatic infectionAround two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.This project was supported by public funds obtained in competitive calls: Grant COV20/00021 (EUR 43,000 from the Instituto de Salud Carlos III—Spanish Ministry of Health and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds. Dr Cruz-Lemini is supported by a Juan Rodés contract JR19/00047, Instituto de Salud Carlos III—Spanish Ministry of Health. The funding bodies had no role in the study design, in the collection or analysis of the data, or in manuscript writing

A sea of opportunities? Innovations related to tourism and fi sheries in marine protected areas

En España existe una diversidad de fi guras de protección ambiental, sirviendo a diferentes propósitos y adaptadas a contextos ecológicos diferentes. Los ejemplos de La Restinga y las Islas Medas- L´Estartit muestran cómo las estrategias de protección marina pueden adaptarse y orientarse hacia diversos fi nes más o menos relacionados con las actividades de la pesca profesional y del turismo. Un aspecto esencial que introducen tales medidas de protección es la posibilidad de variar el entramado de normas y reglas, que afectan o van a regular el acceso de diferentes usuarios a la zona marítimo costera. Las declaraciones proteccionistas introducen cambios en la manera de afectar el recurso, pero sobre todo pueden instituir nuevos entornos o estructuras para generar tales reglas, y variar el poder que cada colectivo posee a su alrededor.In Spain there are a range of environmental protection entities, focused on different purposes on different ecological contexts. The examples of the Restinga and the Medas Islands- L’Estartit show how marine conservation strategies can be oriented toward different goals, more or less related to commercial fi shing and tourism activities. Marine Protected Areas may vary the framework of norms and rules which affects the access of the coastal marine resources for different users or stakeholders. Marine conservationist strategies may introduce changes in the way in which marine resources are affected, but also may institute new structures to generate the rules itself, varying the power that each group has

Cuadernos de género: Políticas y acciones de género. Materiales de formación

En la primera parte, la autora repasa históricamente los tres grandes momentos -olas- de la corriente feminista a nivel europeo y americano, haciendo análisis de las primeras aportaciones y avances de parte de diversas pensadoras y teóricas. En este recorrido cronológico expone lúcidamente cuáles han sido los fundamentos teóricos y los debates surgidos sobre los diferentes marcos geográficos y culturales. En el segundo apartado, Rosa Cobo hace un planteamiento analítico del feminismo como paradigma científico y de investigación que supondrá un envite a los planteamientos androcéntricos de la ciencia dando una especial mirada a las ciencias sociales. En él se pondrán sobre la mesa nociones básicas sobre el patriarcado o la división sexual del trabajo que han marcado líneas centrales de discusión y de enfoques teóricopolíticos. En el último apartado de este capítulo, se esbozan algunas cuestiones centrales sobre el feminismo actual, vislumbrando una posible despolitización del concepto de género, haciendo reflexionar al lector o lectora sobre las estrategias de dominación masculina que siguen vigentes hoy en día y que a través de estas reflexiones pueden irse modificando.Políticas de igualdad de Genero, División sexual del trabajo, Feminismo, Políticas públicas, Planificación de género, Mainstreaming,Transversalidad de género.

Impact of Recommended Maternal Vaccination Programs on the Clinical Presentation of SARS-CoV-2 Infection: A Prospective Observational Study

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vacunes; EmbaràsCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vacunas; EmbarazoCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vaccines; PregnancyThe COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. A total of 1150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.This research was supported by public funds obtained in competitive calls: Grant COV20/ 00021 from the Instituto de Salud Carlos III-Spanish Ministry of Health, and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds

Impact of recommended maternal vaccination programs on the clinical presentation of sars-cov-2 infection: A prospective observational study

The COVID-19 pandemic has raised questions about the possible cross immunity resulting from common vaccination programs and SARS-CoV-2 infection. Therefore, the Spanish Obstetric Emergency group performed a multicenter prospective study on the vaccination status of Influenza and Tdap (diphtheria, tetanus and pertussis vaccine boost administered in adulthood) in consecutive cases of SARS-CoV-2 infection in a pregnancy cohort, in order to assess its possible association with the clinical presentation and severity of symptoms of SARS-CoV-2 infection, as well as to determine the factors that may affect vaccination adherence. A total of 1150 SARS-CoV-2 positive pregnant women from 78 Spanish hospitals were analyzed: 183 had not received either vaccine, 23 had been vaccinated for Influenza only, 529 for Tdap only and 415 received both vaccines. No association was observed between the vaccination status and the clinical presentation of SARS-CoV-2 infection and/or the severity of symptoms. However, a lower adherence to the administration of both vaccines was observed in the Latin-American subgroup. Based on the results above, we reinforce the importance of maternal vaccination programs in the actual pandemic. Health education campaigns should be specially targeted to groups less likely to participate in these programs, as well as for a future SARS-CoV-2 vaccination campaign.This research was supported by public funds obtained in competitive calls: Grant COV20/ 00021 from the Instituto de Salud Carlos III-Spanish Ministry of Health, and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) fund

SARS-CoV-2 Infection and C-Section: A Prospective Observational Study

Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson's classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results. This was a prospective observational study that was carried out in 79 hospitals (Spanish Obstetric Emergency Group) with a cohort of 1704 SARS-CoV-2 PCR-positive pregnant women that were registered consecutively between 26 February and 5 November 2020. The data from 1248 pregnant women who delivered vaginally (vaginal + operative vaginal) was compared with those from 456 (26.8%) who underwent a C-section. C-section patients were older with higher rates of comorbidities, in vitro fertilization and multiple pregnancies (p < 0.05) compared with women who delivered vaginally. Moreover, C-section risk was associated with the presence of pneumonia (p < 0.001) and 41.1% of C-sections in patients with pneumonia were preterm (Robson's 10th category). However, delivery care was similar between asymptomatic and mild-moderate symptomatic patients (p = 0.228) and their predisposing factors to C-section were the presence of uterine scarring (due to a previous C-section) and the induction of labor or programmed C-section for unspecified obstetric reasons. On the other hand, higher rates of hemorrhagic events, hypertensive disorders and thrombotic events were observed in the C-section group (p < 0.001 for all three outcomes), as well as for ICU admission. These findings suggest that this type of delivery was associated with the mother's clinical conditions that required a rapid and early termination of pregnancy.This project was supported by public funds that were obtained in competitive calls: Grant COV20/00021 (EUR 43,000 from the Instituto de Salud Carlos III-Spanish Ministry of Health) and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds

Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of the tumor microenvironment (TME). This work aimed to characterize the residual TME composition in 96 TNBC patients using immunohistochemistry and in situ hybridization techniques and evaluate its prognostic implications for partial responders vs. non-responders. Compared with non-responders, partial responders containing higher levels of CD83+ mature dendritic cells, FOXP3+ regulatory T cells, and IL-15 expression but lower CD138+ cell concentration exhibited better OS and RFS. However, along with tumor diameter and positive nodal status at diagnosis, matrix metalloproteinase-9 (MMP-9) expression in the residual TME was identified as an independent factor associated with the impaired response to NAC. This study yields new insights into the key components of the residual tumor bed, such as MMP-9, which is strictly associated with the lack of a pathological response to NAC. This knowledge might help early identification of TNBC patients less likely to respond to NAC and allow the establishment of new therapeutic targets