723 research outputs found
Tailing Dam Zelazny Most Environmental Hazard
The factors governing the geotechnical stability of copper tailing dam Żelazny Most, the largest in Europe, have been discussed. The efficiency of pumping wells barrier against outflow of contaminated ground water has been predicted for a period of next 15 years
Ocena aktywności seksualnej kobiet w okresie okołomenopauzalnym
Wstęp. Zachowania seksualne kobiet w okresie okołomenopauzalnym ulegają znacznym modyfikacjom. Jeszcze do połowy XX wieku menopauza wiązała się ze stereotypowym pojęciem wygasania potrzeb i zainteresowania seksualnością w tym okresie życia. Współczesne kobiety, które przechodzą okres okołomenopauzalny traktują życie seksualne jako ważny aspekt funkcjonowania społecznego.
Cel pracy. Celem pracy była ocena aktywności seksualnej kobiet w okresie okołomenopauzalnym.
Materiał i metoda. Badania, metodą sondażu diagnostycznego, przeprowadzono w grupie 150 kobiet w okresie okołomenopauzalnym. Narzędzie stanowił samodzielnie opracowany, niestandaryzowany kwestionariusz ankiety. Uzyskane wyniki badań pod-dano analizie statystycznej.
Wnioski. Kobiety w okresie okołomenopauzalnym są aktywne seksualnie. Wiek, miejsce zamieszkania, wykształcenie i stan cywilny warunkują aktywnością seksualną kobiet w okresie okołomenopauzalnym. Natomiast występowanie fizycznych i psychicznych objawów okresu okołomenopauzalnego oraz stosowanie, lub nie stosowanie terapii zastępczej nie mają wpływu na aktywność seksualną kobiet w tym okresie.Introduction. Sexual behaviour in women’s perimeno-pausal period is very likely to change. Until the midtwentieth century, menopause was associated with the stereotypical notion of the termination of needs and interests of sexuality in this peri-od of life. Contemporarily, women who undergo the period of perimenopause treat sexual life as an important aspect of social functioning. Aim of the study. The aim of the study was to assess sexual activity in perimenopausal women. Materials and methods. The research was conducted using the method of diagnostic poll among a group of 150 perimenopausal women. The research tool was the authors’ own, non-standardised questionnaire. The results were analysed statistically. Conclusions. Women in perimenopause are sexually active. Age, place of residence, education and marital status determine sexual activity in perimenopausal women. However, the occurrence of physical and psychological symptoms of perimenopause and the decision whether or not to undergo replacement therapy does not affect the sexual activity of women during this period
GDR Feeding of the Highly-Deformed Band in 42Ca
The gamma-ray spectra from the decay of the GDR in the compound nucleus
reaction 18O+28Si at bombarding energy of 105 MeV have been measured in an
experiment using the EUROBALL IV and HECTOR arrays. The obtained experimental
GDR strength function is highly fragmented, with a low energy (10 MeV)
component, indicating a presence of a large deformation and Coriolis effects.
In addition, the preferential feeding of the highly-deformed band in 42Ca by
this GDR low energy component is observed.Comment: 6 pages, 2 figures, Proceedings of the Zakopane2004 Symposium, to be
published in Acta Phys. Pol. B36 (2005
3-Cyano-11-oxo-3,4-seco-12a-aza-C-homoolean-4(23)-en-28-oic acid methyl ester
The title compound, C31H48N2O3, is a Beckmann rearrangement product. The isopropenyl and methoxycarbonyl groups have β-orientations, whereas the 2-cyanoethyl group has an α-orientation. In the triterpenoid skeleton, the seven-membered lactam ring, as well as the three six-membered carbocyclic rings, have chair conformations. In the crystal, molecules are linked via nonclassical C—H⋯O hydrogen bonds into layers parallel to the ab plane
Large Deformation Effects in the N = Z 44Ti Compound Nucleus
The N = Z 44Ti* nucleus has been populated in Fusion Evaporation process at
very high excitation energies and angular momenta using two entrance channels
with different mass-asymmetry. The deformation effects in the rapidly rotating
nuclei have been investigated through the energy distribution of the
alpha-particle combined to statistical-model calculations. In the case of
low-multiplicity events, the ratio between first particle emitted has been
measured and shows significant disagreement with the predictions of the
statistical-model. This may explain The large discrepancies observed in proton
energy spectra measured in previous experiments performed in the same mass
region.Comment: Proceeding of the 10th International Conference on Nuclear Reaction
Mechanisms, Varenna Italy, June 9-13 2003. 10 pages, 6 figures, 1 tabl
Hyperactive ERK and Persistent mTOR Signaling Characterize Vemurafenib Resistance in Papillary Thyroid Cancer Cells
Clinical studies evaluating targeted BRAFV600E inhibitors in advanced thyroid cancer patients are currently underway. Vemurafenib (BRAFV600E inhibitor) monotherapy has shown promising results thus far, although development of resistance is a clinical challenge. The objective of this study was to characterize development of resistance to BRAFV600E inhibition and to identify targets for effective combination therapy. We created a line of BCPAP papillary thyroid cancer cells resistant to vemurafenib by treating with increasing concentrations of the drug. The resistant BCPAP line was characterized and compared to its sensitive counterpart with respect to signaling molecules thought to be directly related to resistance. Expression and phosphorylation of several critical proteins were analyzed by Western blotting and dimerization was evaluated by immunoprecipitation. Resistance to vemurafenib in BCPAP appeared to be mediated by constitutive overexpression of phospho-ERK and by resistance to inhibition of both phospho-mTOR and phospho-S6 ribosomal protein after vemurafenib treatment. Expression of potential alternative signaling molecule, CRAF, was not increased in the resistant line, although formation of CRAF dimers appeared increased. Expression of membrane receptors HER2 and HER3 was greatly amplified in the resistant cancer cells. Papillary thyroid cancer cells were capable of overcoming targeted BRAFV600E inhibition by rewiring of cell signal pathways in response to prolonged vemurafenib therapy. Our study suggests that in vitro culture of cancer cells may be useful in assessing molecular resistance pathways. Potential therapies in advanced thyroid cancer patients may combine vemurafenib with inhibitors of CRAF, HER2/HER3, ERK, and/or mTOR to delay or abort development of resistance
First identification of excited states in the T = 1/2 nucleus Pd
The first experimental information about excited states in the N = Z + 1 nucleus 93Pd is presented. The experiment was performed using a 205 MeV 58Ni beam from the Vivitron accelerator at IReS, Strasbourg, impinging on a bismuth-backed 40Ca target. Gamma-rays, neutrons and charged particles emitted in the reactions were detected using the Ge detector array Euroball, the Neutron Wall liquid-scintillator array and the Euclides Si charged-particle detector system. The experimental level scheme is compared with the results of new shell model calculations which predict a coupling scheme with aligned neutron-proton pairs to greatly influence the level structure of nuclei at low excitation energies
Strong Deformation Effects in Hot Rotating 46Ti
Exotic-deformation effects in 46Ti nucleus were investigated by analysing the
high-energy gamma-ray and the alpha-particle energy spectra. One of the
experiments was performed using the charged-particle multi-detector array ICARE
together with a large volume (4"x4") BGO detector. The study focused on
simultaneous measurement of light charged particles and gamma-rays in
coincidence with the evaporation residues. The experimental data show a
signature of very large deformations of the compound nucleus in the Jacobi
transition region at the highest spins. These results are compared to data from
previous experiments performed with the HECTOR array coupled to the EUROBALL
array, where it was found that the GDR strength function is highly fragmented,
strongly indicating a presence of nuclei with very large deformation.Comment: 10 pages, 6 figures, Proceedings of the Zakopane Conference on
Nuclear Physics, to be published in Acta Phys. Pol. B (2007
Discrimination of papillary thyroid cancer from non-cancerous thyroid tissue based on lipid profiling by mass spectrometry imaging
Introduction: The distinction of papillary thyroid carcinomas from benign thyroid lesions has important implication for clinical management. Classification based on histopathological features can be supported by molecular biomarkers, including lipidomic signatures, identified with the use of high-throughput mass spectrometry techniques. Formalin fixation is a standard procedure for stabilization and preservation of tissue samples, therefore this type of samples constitute highly valuable source of clinical material for retrospective molecular studies. In this study we used mass spectrometry imaging to detect lipids discriminating papillary cancer from not cancerous thyroid directly in formalin-fixed tissue sections. Material and methods: For this purpose imaging and profiling of lipids present in non-malignant and cancerous thyroid tissue specimens were conducted. High resolution MALDI-Q-Ion Mobility-TOF-MS technique was used for lipidomic analysis of formalin fixed thyroid tissue samples. Lipids were identified by the comparison of the exact molecular masses and fragmentation pathways of the protonated molecule ions, recorded during the MS/MS experiments, with LIPID MAPS database. Results: Several phosphatidylcholines (32:0, 32:1, 34:1 and 36:3), sphingomyelins (34:1 and 36:1) and phosphatidic acids (36:2 and 36:3) were detected and their abundances were significantly higher in cancerous tissue compared to non-cancerous tissue. The same lipid species were detected in formalin-fixed as in fresh-frozen tissue, but [M + Na]+ions were the most abundant in formalin fixed whereas [M + K]+ions were predominant in fresh tissue. Conclusions: Our results prove the viability of MALDI-MSI for analysis of lipid distribution directly in formalin-fixed tissue, and the potential for their use in the classification of thyroid diseases
In ovo injection of prebiotics and synbiotics affects the digestive potency of the pancreas in growing chickens
Abstract The purpose of the study was to examine the effect of 2 prebiotics and 2 synbiotics on the digestive potency of pancreas in 1-, 3-, 7-, 14-, 21-, and 34-day-old cockerels. Prebiotics (inulin and Bi2 tos) and synbiotics (inulin + Lactococcus lactis subsp. lactis and Bi2 tos + Lactococcus lactis subsp. cremoris) were injected in ovo into the air cell on the 12th d embryonic development. Their application increased the activity of amylase, lipase, and trypsin in the pancreas. The most pronounced changes were observed at the end of the investigated rearing period (d 34). The strongest stimulative effects on amylase were shown by both synbiotics, on lipase synbiotic Bi2 tos + Lactococcus lactis subsp. cremoris, and on trypsin all the used prebiotics and synbiotics. Simultaneously, neither the absolute nor the relative mass of the pancreas in comparison to control group were changed. Also, the injected in ovo compounds did not cause a deterioration in the posthatching condition of the chicken liver, as determined by measurement of the activity of marker enzymes in the blood (alanine aminotransferase and aspartate aminotransferase). Treatment with the prebiotics and synbiotics did not change the feed conversion ratio but Bi2 tos (galacto-oligosaccharide) and inulin (fructan) + Lactococcus lactis subsp. lactis significantly increased final BW
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