Impacts of climate change of seaports: A survey of knowledge, perceptions, and planning efforts among port administrators

Port authorities from around the world were surveyed to ascertain how administrators feel climate change might impact their operations, what level of change would be problematic, and how they plan to adapt to new conditions. The survey was distributed to 350 major ports through two leading international port organizations, the International Association of Ports and Harbors and the American Association of Port Authorities. (PDF contains 4 pages

Core curricular elements of effective undergraduate technology management academic programs

Technology management skills have become increasingly important to employers in today’s rapidly changing technological environment; yet a scarcity of research exists regarding desired core competencies of undergraduate technology management majors. The purpose of this study was to determine the core curricular elements of an effective undergraduate technology management academic program. A quantitative mixed-mode (Internet-based and paper-based) survey design using a 5-point Likert rating (strongly agree, somewhat agree, neither agree nor disagree, somewhat disagree, and strongly disagree) was used to solicit opinions from members of the sample population regarding core curricular elements of effective undergraduate technology management programs. Implementation of this research project included the following 5 phases: (a) identification of the sample population, (b) selection of survey software, (c) survey instrument design and pilot testing, (d) data gathering, and (e) data analysis. This exploratory descriptive study employed purposive expert sampling of 180 people with technology management expertise in four industry sectors (i.e., business services, education, government, and manufacturing); in addition, 18 executive board members of the Michigan Economic Development Corporation and 30 members of the Southern Wayne County Chamber of Commerce were queried. Information regarding the relative perceived importance of each of the following eight core technology management competency areas was sought: (a) strategic management of technology, (b) management of innovation and product development, (c) management of technological change, (d) management of organizational change, (e) project management, (f) assessment and evaluation of technology, (g) quality management of technology, and (h) information and knowledge management. Significance was determined at the .05 level

Dependence of Acute Myeloid Leukemia on Adhesion within the Bone Marrow Microenvironment

Acute myeloid leukemia (AML) cells home to the endosteal region of the bone marrow. They interact with bone marrow stromal components including extracellular matrix proteins, glycosaminoglycans, and stromal cells, by which they derive proliferative and growth inhibitory signals. Furthermore, adhesion to marrow stroma confers chemotherapy drug resistance and thereby promotes leukemia survival. A subpopulation of the leukemic blasts, known as leukemia stem cells, that are capable of propagating the leukemia, remain sheltered in the bone marrow microenvironment, exhibit resistance to chemotherapy, and serve as the origin of relapse after a variable period of remission. Detachment of these cells from the bone marrow in combination with chemotherapy may improve the outcome of therapy for AML

New routes to cleanliness : nanocomposite coatings offer advantages over PTFE in food production

A new class of anti-adhesive coatings has been studied for potential use in industrial food production. They can be sprayed and cured at lower temperatures than current PTFE coatings. The polymer binder matrix incorporates perfluorinated comonomers and nanoscale hard particles. Polyurethane based systems gave the best abrasion and chemical resistance, but a polyimide-based system performed well in dry processing tests

Latino Parents\u27 Perspectives on Barriers to Autism Diagnosis

Recent estimates suggest that Autism Spectrum Disorders (ASDs) affect more than 1% of U.S. children over age 3, and rates ASD diagnosis may be increasing.1 ASDs can be reliably diagnosed,2 and early diagnosis is associated with improved long-term developmental and family outcomes.3 However, many children meeting ASD diagnostic criteria are never diagnosed4 or are diagnosed years after onset of symptoms.4,5 Delayed diagnosis is a particular problem among Latino children:6,7 Latino children receive a diagnosis of an ASD 2.5 years later than white non-Latino children.8 Latino children are also less likely to carry an ASD diagnosis; however, when diagnosed, they are more likely to have severe symptoms than white non-Latino children.4,9,1

Three-Dimensional Model for the Human Cl−/HCO3− Exchanger, AE1, by Homology to the E. coli ClC Protein

AbstractAE1 mediates electroneutral 1:1 exchange of bicarbonate for chloride across the plasma membrane of erythrocytes and type A cells of the renal collecting duct. No high-resolution structure is available for the AE1 membrane domain, which alone is required for its transport activity. A recent electron microscopy structure of the AE1 membrane domain was proposed to have a similar protein fold to ClC chloride channels. We developed a three-dimensional homology model of the AE1 membrane domain, using the Escherichia coli ClC channel structure as a template. This model agrees well with a long list of biochemically established spatial constraints for AE1. To investigate the AE1 transport mechanism, we created point mutations in regions corresponding to E. coli ClC transport mechanism residues. When expressed in HEK293 cells, several mutants had Cl−/HCO3− exchange rates significantly different from that of wild-type AE1. When further assessed in Xenopus laevis oocytes, there were significant changes in the transport activity of several AE1 point mutants as assessed by changes in pH. None of the mutants, however, added an electrogenic component to AE1 transport activity. This indicates that the AE1 point mutants altered the transport activity of AE1, without changing its electrogenicity and stoichiometry. The homology model successfully identified residues in AE1 that are critical to AE1 transport activity. Thus, we conclude that AE1 has a similar protein fold to ClC chloride channels

Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data

Objectives To use changes in heart disease mortality rates with age to investigate the plausibility of attributing women’s lower heart disease mortality than men to the protective effects of premenopausal sex hormones

New routes to cleanliness : nanocomposite coatings offer advantages over PTFE in food production

A new class of anti-adhesive coatings has been studied for potential use in industrial food production. They can be sprayed and cured at lower temperatures than current PTFE coatings. The polymer binder matrix incorporates perfluorinated comonomers and nanoscale hard particles. Polyurethane based systems gave the best abrasion and chemical resistance, but a polyimide-based system performed well in dry processing tests

Why so many published sensitivity analyses are false: a systematic review of sensitivity analysis practices

Sensitivity analysis provides information on the relative importance of model input parameters and assumptions. It is distinct from uncertainty analysis, which addresses the question ‘How uncertain is the prediction?’ Uncertainty analysis needs to map what a model does when selected input assumptions and parameters are left free to vary over their range of existence, and this is equally true of a sensitivity analysis. Despite this, many uncertainty and sensitivity analyses still explore the input space moving along one-dimensional corridors leaving space of the input factors mostly unexplored. Our extensive systematic literature review shows that many highly cited papers (42% in the present analysis) fail the elementary requirement to properly explore the space of the input factors. The results, while discipline-dependent, point to a worrying lack of standards and recognized good practices. We end by exploring possible reasons for this problem, and suggest some guidelines for proper use of the methods