Aerobic exercise training and burnout: A pilot study with male participants suffering from burnout

Occupational burnout is associated with severe negative health effects. While stress management programs proved to have a positive influence on the well-being of patients suffering from burnout, it remains unclear whether aerobic exercise alleviates burnout severity and other parameters related to occupational burnout. Therefore, the main purpose of this study was to pilot-test the potential outcomes of a 12-week exercise training to generate hypotheses for future larger scale studies.; The sample consisted of 12 male participants scoring high on the MBI emotional exhaustion and depersonalization subscales. The training program took place in a private fitness center with a 17.5 kcal/kg minimum requirement of weekly energy expenditure.; The key findings are that increased exercise reduced overall perceived stress as well as symptoms of burnout and depression. The magnitude of the effects was large, revealing changes of substantial practical relevance. Additionally, profiles of mood states improved considerably after single exercise sessions with a marked shift towards an iceberg profile.; Among burnout patients, the findings provide preliminary evidence that exercise has the potential to reduce stress and prevent the development of a deeper depression. This has important health implications given that burnout is considered an antecedent of depressive disorders.; ClinicalTrials.gov Identifier: ISRNCT01575743

Die Macht der Wenigen. Aristokratische Herrschaftspraxis, Kommunikation und 'edler' Lebensstil in Antike und Früher Neuzeit

Der Sammelband stellt das Phänomen Macht der Wenigen als verbindendes Element der politischen Kulturen der Antike heraus. Dabei gewinnt der Begriff Aristokratie im Spannungsfeld zwischen prinzipieller Offenheit un

Benchmarking in a rotating annulus: a comparative experimental and numerical study of baroclinic wave dynamics

The differentially heated rotating annulus is a widely studied tabletop-size laboratory model of the general mid-latitude atmospheric circulation. The two most relevant factors of cyclogenesis, namely rotation and meridional temperature gradient are quite well captured in this simple arrangement. The radial temperature difference in the cylindrical tank and its rotation rate can be set so that the isothermal surfaces in the bulk tilt, leading to the formation of baroclinic waves. The signatures of these waves at the free water surface have been analyzed via infrared thermography in a wide range of rotation rates (keeping the radial temperature difference constant) and under different initial conditions. In parallel to the laboratory experiments, five groups of the MetStr\"om collaboration have conducted numerical simulations in the same parameter regime using different approaches and solvers, and applying different initial conditions and perturbations. The experimentally and numerically obtained baroclinic wave patterns have been evaluated and compared in terms of their dominant wave modes, spatio-temporal variance properties and drift rates. Thus certain ``benchmarks'' have been created that can later be used as test cases for atmospheric numerical model validation

Wissensstandsanalyse zu Qualität, Verbraucherschutz und Verarbeitung ökologischer Lebensmittel

Zielsetzung des Projektes war es, den aktuellen Stand des Wissens zur Qualität und Verarbeitung ökologischer Lebensmittel sowie zum Verbraucherschutz aufzuzeigen und zu bewerten. Das Projektteam setzte sich aus Wissenschaftlern des Forschungsinstituts für biologischen Landbau (Deutschland und Schweiz), des Büros für Lebensmittelkunde, des Forschungsrings für Biologisch-Dynamische Wirtschaftsweise e.V. sowie des Fachgebiets Ökologische Lebensmittelqualität und Ernährungskultur der Universität Kassel zusammen. In dem zeitlich sehr begrenzten Projekt fokussierte die Arbeitsgruppe die Betrachtung auf folgende Themenkomplexe und Produktgruppen: Bereich Qualität - Ernährung - Sensorik - Ökospezifische Qualitäten - Authentizität und Rückverfolgbarkeit Bereich Verarbeitung - Rohwaren/Lagerung und Technologien für die Produktgruppen: -- Getreide -- Milch -- Fleisch -- Obst und Gemüse und Erzeugnisse aus diesen - Nachhaltigkeit im Unternehmen und entlang der Prozesskette - Verpackung Vorhandenes Wissen, aktuelle Fragestellungen und Entwicklungsrichtungen wurden nach thematisch angepassten Vorgehensweisen identifiziert und anhand internationaler Literatur und Experteninterviews diskutiert. Zu allen Themenkomplexen wurden kurze und allgemeinverständliche Reports erstellt, die einen schnellen und fundierten Überblick zum aktuellen Stand des Wissens und zu eventuellen Wissenslücken geben. Der Abschlussreport wurde in deutscher und englischer Sprache veröffentlicht. Insgesamt wurde festgestellt, dass in den betrachteten Themenkomplexen erheblicher Bedarf an Forschung und Entwicklung sowie an Wissenstransfer besteht. Neben einer Reihe von Detailfragen sind grundlegende Themen, wie beispielsweise das Anforderungsprofil an eine „ökologische Verarbeitung“, nicht hinreichend erforscht und geklärt. Diese Arbeiten sind jedoch Voraussetzung für die Bearbeitung von Detailthemen, da hier Aufgabenstellungen, Schwerpunktsetzungen und Methoden definiert werden

Effects of Aerobic Exercise on Cortisol Stress Reactivity in Response to the Trier Social Stress Test in Inpatients with Major Depressive Disorders: A Randomized Controlled Trial

Physical activity is associated with a favourable (blunted) cortisol stress reactivity in healthy people. However, evidence from experimental study and with psychiatric patients is missing. This study examines whether exercise training impacts on cortisol stress reactivity in inpatients with major depressive disorder (MDD). These new insights are important because the stress reactivity of healthy people and patients with severe symptoms of depression might differ. Methods: The study was designed as a randomized controlled trial (trial registration number: NCT02679053). In total, 25 patients (13 women, 12 men, mean age: 38.1 12.0 years) completed a laboratory stressor task before and after a six-week intervention period. Nine samples of salivary free cortisol were taken before and after the Trier social stress test (TSST). Fourteen participants took part in six weeks of aerobic exercise training, while 11 patients were allocated to the control condition. While the primary outcome of the study was depressive symptom severity, the focus of this paper is on one of the secondary outcomes (cortisol reactivity during the TSST). The impact of aerobic exercise training was examined with a repeated-measures analysis of variance. We also examined the association between change in depression and cortisol response via correlational analysis. Cortisol reactivity did not change from baseline to post-intervention, either in the intervention or the control group. Participation in six weeks of aerobic exercise training was not associated with participants' cortisol reactivity. Moreover, depressive symptom change was not associated with change in cortisol response. Aerobic exercise training was not associated with patients' stress reactivity in this study. Because many patients initially showed a relatively flat/blunted cortisol response curve, efforts might be needed to find out which treatments are most efficient to promote a normalization of HPA axis reactivity

Post-Operative Radiotherapy of the Rhabdomyosarcoma R1H of the Rat

Purpose. Post-operative radiotherapy (RT) is routinely applied in the treatment of several human tumours. The aim of the present study was to investigate the value of post-operative RT in a rat model

VEGF-A165b levels are reduced in breast cancer patients at primary diagnosis but increase after completion of cancer treatment

The antiangiogenic splice variant VEGF-A165b is downregulated in a variety of cancer entities, but little is known so far about circulating plasma levels. The present analysis addresses this question and examines circulating VEGF-A/VEGF-A165b levels in a collective of female high-risk breast cancer patients over the course of treatment. Within the SUCCES-A trial 205 patients were recruited after having received primary breast surgery. Using ELISA VEGF-A/VEGF-A165b concentrations were determined and correlated to clinical characteristics (1) before adjuvant chemotherapy, (2) four weeks and (3) two years after therapy and compared to healthy controls (n = 107). VEGF(165b) levels were significantly elevated after completion of chemotherapy. Within the breast cancer cohort, VEGF-A165b levels increased two years after completion of chemotherapy. VEGF-A plasma concentrations were significantly elevated in the breast cancer cohort at all examined time points and decreased after treatment. VEGF-A levels two years after chemotherapy correlated with increased cancer related mortality, no such correlation could be found between VEGF-A165b and the examined clinical characteristics. Compared to controls, VEGF-A/VEGF-A165b ratios were decreased in patients before and after chemotherapy. Our data suggests that circulating VEGF-A165b is significantly reduced in women with primary breast cancer at time of diagnosis;furthermore, levels change during adjuvant treatment

a comparative experimental and numerical study of baroclinic wave dynamics

The differentially heated rotating annulus is a widely studied tabletop-size laboratory model of the general mid-latitude atmospheric circulation. The two most relevant factors of cyclogenesis, namely rotation and meridional temperature gradient are quite well captured in this simple arrangement. The radial temperature difference in the cylindrical tank and its rotation rate can be set so that the isothermal surfaces in the bulk tilt, leading to the formation of baroclinic waves. The signatures of these waves at the free water surface have been analyzed via infrared thermography in a wide range of rotation rates (keeping the radial temperature difference constant) and under different initial conditions. In parallel to the laboratory experiments, five groups of the MetStröm collaboration have conducted numerical simulations in the same parameter regime using different approaches and solvers, and applying different initial conditions and perturbations. The experimentally and numerically obtained baroclinic wave patterns have been evaluated and compared in terms of their dominant wave modes, spatio-temporal variance properties and drift rates. Thus certain “benchmarks” have been created that can later be used as test cases for atmospheric numerical model validation