Science mainly medical and literature mainly medieval

In the St. Luke`s Day Oration organised by the Malta Branch of the British Medical Association on the 18th October 1966, Prof. R.J. Beck discusses the relation between Science, from a medical theme perspective, and literature within a medieval context. Three aspects of the medieval medicine – the dependence on astronomy, the doctrine of the humours and the physiognomia are discussed. This oration mainly focuses on particular aspects of Geoffrey Chaucer’s specific literary works: Chaucer's portrait of the Doctor in the General Prologue to the Canterbury Tales; The three principals in The Knight's Tale and The Man of Law`s Tale. Furthermore, captions from the book “Chaucer and the Medieval Sciences”, Clyde, W.C. (1960) are also outlined.peer-reviewe

An Objective Assessment of the Variability in Number of Drops per Bottle of Glaucoma Medication

Background: The purpose of this study is to evaluate the number of eyedrops available per bottle of a variety of commonly prescribed glaucoma medications. Methods: Six bottles of each glaucoma medication were tested: three each in the vertical and horizontal orientations. Bottles were housed in a customized force gauge apparatus designed to mimic ballpoint fingertip contact with a bottle. At a standard rate, all drops were expressed from each bottle and counted with an automated drop counter. Simultaneously, bottle volume was measured and drop size and number were also estimated. The main outcome measures were: total number of drops, volume per bottle and drops per milliliter (mL) of glaucoma medication. Results: A total of 192 bottles from 32 bottle designs and manufacturers were tested. Twenty-two of the 32 bottle designs had a significantly different mean number of drops in the vertical and horizontal positions, with 10 designs have more drops dispensed in the horizontal orientation and 12 in the vertical orientation. Six of the 32 bottle designs had a significantly different mean total bottle volume in the vertical and horizontal positions, with all designs having greater volume in the vertical position. An adjusted ratio of mean number of drops/mean bottle volume demonstrated a range from 20.9 drops/mL to 40.8 drops/mL. Conclusions: There is significant variability in drops and volume available per bottle of glaucoma medication depending on both the bottle position and manufacturer. These data point to the need for circumspection in prescribing glaucoma medications and caution in evaluating therapeutic outcomes

Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage.

UV damage to the skin leads to the release of noncoding RNA (ncRNA) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3). This release of ncRNA triggers inflammation in the skin following UV damage. Recently, TLR3 activation was also shown to aid wound repair and increase the expression of genes associated with permeability barrier repair. Here, we sought to test whether skin barrier repair after UVB damage is dependent on the activation of TLR3. We observed that multiple ncRNAs induced expression of skin barrier repair genes, that the TLR3 ligand Poly (I:C) also induced expression and function of tight junctions, and that the ncRNA U1 acts in a TLR3-dependent manner to induce expression of skin barrier repair genes. These observations were shown to have functional relevance as Tlr3-/- mice displayed a delay in skin barrier repair following UVB damage. Combined, these data further validate the conclusion that recognition of endogenous RNA by TLR3 is an important step in the program of skin barrier repair

An exploratory randomised trial of a simple, brief psychological intervention to reduce subsequent suicidal ideation and behaviour in patients admitted to hospital for self-harm.

Background Implementation intentions link triggers for self-harm with coping skills and appear to create an automatic tendency to invoke coping responses when faced with a triggering situation. Aims To test the effectiveness of implementation intentions in reducing suicidal ideation and behaviour in a high-risk group. Method Two hundred and twenty-six patients who had self-harmed were randomised to: (a) forming implementation intentions with a ‘volitional help sheet’; (b) self-generating implementation intentions without help; or (c) thinking about triggers and coping, but not forming implementation intentions. We measured self-reported suicidal ideation and behaviour, threats of suicide and likelihood of future suicide attempt at baseline and then again at the 3-month follow-up. Results All suicide-related outcome measures were significantly lower at follow-up among patients forming implementation intentions compared with those in the control condition (ds>0.35). The volitional help sheet resulted in fewer suicide threats (d = 0.59) and lowered the likelihood of future suicide attempts (d = 0.29) compared with patients who self-generated implementation intentions. Conclusions Implementation intention-based interventions, particularly when supported by a volitional help sheet, show promise in reducing future suicidal ideation and behaviour

CHANG-ES VI: Probing Supernova Energy Deposition in Spiral Galaxies Through Multi-Wavelength Relationships

How a galaxy regulates its SNe energy into different interstellar/circumgalactic medium components strongly affects galaxy evolution. Based on the JVLA D-configuration C- (6 GHz) and L-band (1.6 GHz) continuum observations, we perform statistical analysis comparing multi-wavelength properties of the CHANG-ES galaxies. The high-quality JVLA data and edge-on orientation enable us for the first time to include the halo into the energy budget for a complete radio-flux-limited sample. We find tight correlations of $L_{\rm radio}$ with the mid-IR-based SFR. The normalization of our $I_{\rm 1.6GHz}/{\rm W~Hz^{-1}}-{\rm SFR}$ relation is $\sim$2-3 times of those obtained for face-on galaxies, probably a result of enhanced IR extinction at high inclination. We also find tight correlations between $L_{\rm radio}$ and the SNe energy injection rate $\dot{E}_{\rm SN(Ia+CC)}$, indicating the energy loss via synchrotron radio continuum accounts for $\sim0.1\%$ of $\dot{E}_{\rm SN}$, comparable to the energy contained in CR electrons. The integrated C-to-L-band spectral index is $\alpha\sim0.5-1.1$ for non-AGN galaxies, indicating a dominance by the diffuse synchrotron component. The low-scatter $L_{\rm radio}-{\rm SFR}$/$L_{\rm radio}-\dot{E}_{\rm SN (Ia+CC)}$ relationships have super-linear logarithmic slopes at $\sim2~\sigma$ in L-band ($1.132\pm0.067$/$1.175\pm0.102$) while consistent with linear in C-band ($1.057\pm0.075$/$1.100\pm0.123$). The super-linearity could be naturally reproduced with non-calorimeter models for galaxy disks. Using Chandra halo X-ray measurements, we find sub-linear $L_{\rm X}-L_{\rm radio}$ relations. These results indicate that the observed radio halo of a starburst galaxy is close to electron calorimeter, and a galaxy with higher SFR tends to distribute an increased fraction of SNe energy into radio emission (than X-ray).Comment: 16 pages, 6 figures, 1 table, MNRAS in pres