772 research outputs found
Use of neuraminidase inhibitors for rapid containment of influenza: a systematic review and meta-analysis of individual and household transmission studies
Objectives: To assess the effectiveness of neuraminidase inhibitors for use in rapid containment of influenza.
Method: We conducted a systematic review and meta-analysis in accordance with the PRISMA statement. Healthcare databases and sources of grey literature were searched up to 2012 and records screened against protocol eligibility criteria. Data extraction and risk of bias assessments were performed using a piloted form. Results were synthesised narratively and we undertook meta-analyses to calculate pooled estimates of effect, statistical heterogeneity and assessed publication bias.
Findings: Nine randomised controlled trials (RCTs) and eight observational studies met the inclusion criteria. Neuraminidase inhibitors provided 67 to 89% protection for individuals following prophylaxis. Meta-analysis of individual protection showed a significantly lower pooled odds of laboratory confirmed seasonal or influenza A(H1N1) pdm09 infection following oseltamivir usage compared to placebo or no therapy (n=8 studies; odds ratio (OR) 50.11; 95% confidence interval (CI)=50.06 to 0.20; p<0.001; I-2=58.7%). This result was comparable to the pooled odds ratio for individual protection with zanamivir (OR=0.23; 95% CI 0.16 to 0.35). Similar point estimates were obtained with widely overlapping 95% CIs for household protection with oseltamivir or zanamivir. We found no studies of neuraminidase inhibitors to prevent population-wide community transmission of influenza.
Conclusion: Oseltamivir and zanamivir are effective for prophylaxis of individuals and households irrespective of treatment of the index case. There are no data which directly support an effect on wider community transmission
Implementation of an Optimal First-Order Method for Strongly Convex Total Variation Regularization
We present a practical implementation of an optimal first-order method, due
to Nesterov, for large-scale total variation regularization in tomographic
reconstruction, image deblurring, etc. The algorithm applies to -strongly
convex objective functions with -Lipschitz continuous gradient. In the
framework of Nesterov both and are assumed known -- an assumption
that is seldom satisfied in practice. We propose to incorporate mechanisms to
estimate locally sufficient and during the iterations. The mechanisms
also allow for the application to non-strongly convex functions. We discuss the
iteration complexity of several first-order methods, including the proposed
algorithm, and we use a 3D tomography problem to compare the performance of
these methods. The results show that for ill-conditioned problems solved to
high accuracy, the proposed method significantly outperforms state-of-the-art
first-order methods, as also suggested by theoretical results.Comment: 23 pages, 4 figure
Low-Energy Universality in Atomic and Nuclear Physics
An effective field theory developed for systems interacting through
short-range interactions can be applied to systems of cold atoms with a large
scattering length and to nucleons at low energies. It is therefore the ideal
tool to analyze the universal properties associated with the Efimov effect in
three- and four-body systems. In this "progress report", we will discuss recent
results obtained within this framework and report on progress regarding the
inclusion of higher order corrections associated with the finite range of the
underlying interaction.Comment: Commissioned article for Few-Body Systems, 47 pp, 16 fig
Convergence of the critical attractor of dissipative maps: Log-periodic oscillations, fractality and nonextensivity
For a family of logistic-like maps, we investigate the rate of convergence to
the critical attractor when an ensemble of initial conditions is uniformly
spread over the entire phase space. We found that the phase space volume
occupied by the ensemble W(t) depicts a power-law decay with log-periodic
oscillations reflecting the multifractal character of the critical attractor.
We explore the parametric dependence of the power-law exponent and the
amplitude of the log-periodic oscillations with the attractor's fractal
dimension governed by the inflexion of the map near its extremal point.
Further, we investigate the temporal evolution of W(t) for the circle map whose
critical attractor is dense. In this case, we found W(t) to exhibit a rich
pattern with a slow logarithmic decay of the lower bounds. These results are
discussed in the context of nonextensive Tsallis entropies.Comment: 8 pages and 8 fig
A preliminary investigation of schematic beliefs and unusual experiences in children
Background
In cognitive models of adult psychosis, schematic beliefs about the self and others are important vulnerability and maintaining factors, and are therefore targets for psychological interventions. Schematic beliefs have not previously been investigated in children with distressing unusual, or psychotic-like, experiences (UEDs). The aim of this study was firstly to investigate whether a measure of schematic beliefs, originally designed for adults with psychosis, was suitable for children; and secondly, to examine the association of childhood schematic beliefs with internalising and externalising problems and with UEDs.
Method
Sixty-seven children aged 8–14 years, with emotional and behavioural difficulties, completed measures of UEDs, internalising (depression and anxiety), and externalising (conduct and hyperactivity-inattention) problems, together with the Brief Core Schema Scales (BCSS).
Results
The BCSS was readily completed by participants, and scale psychometric properties were good. Children tended to view themselves and others positively. Internalising and externalising problems and UEDs were all associated with negative schematic beliefs; effect sizes were small to medium.
Conclusions
Schematic beliefs in young people can be measured using the BCSS, and negative schematic beliefs are associated with childhood psychopathology and with UEDs. Schematic beliefs may therefore form a useful target in psychological interventions for young people with UEDs
Financial incentives for large-scale wetland restoration: beyond markets to common asset trusts
Wetlands provide $47.4 trillion/year worth of ecosystem services globally and support immense biodiversity, yet face widespread drainage and pollution, and large-scale wetlands restoration is urgently needed. Payment for ecosystem service (PES) schemes provide a viable avenue for funding large-scale wetland restoration. However, schemes around the globe differ substantially in their goals, structure, challenges, and effectiveness in supporting large-scale wetland restoration. Here, we suggest wetland-based PES schemes use common asset trusts (CATs) to build investment portfolios of wetlands across landscapes that sustain and enhance overall provision of multiple ecosystem services. CATs can meet the needs of multiple investors, permit bundled payments, and provide flexibility to invest in the restoration of numerous services/values, all using a coordinated, highly collaborative, prioritized, and transparent process. CATs would support financial viability, facilitate efficiency to reduce administrative burdens, and enable credibility and social licence building to restore wetland values and services globally
Local and macroscopic tunneling spectroscopy of Y(1-x)CaxBa2Cu3O(7-d) films: evidence for a doping dependent is or idxy component in the order parameter
Tunneling spectroscopy of epitaxial (110) Y1-xCaxBa2Cu3O7-d films reveals a
doping dependent transition from pure d(x2-y2) to d(x2-y2)+is or d(x2-y2)+idxy
order parameter. The subdominant (is or idxy) component manifests itself in a
splitting of the zero bias conductance peak and the appearance of subgap
structures. The splitting is seen in the overdoped samples, increases
systematically with doping, and is found to be an inherent property of the
overdoped films. It was observed in both local tunnel junctions, using scanning
tunneling microscopy (STM), and in macroscopic planar junctions, for films
prepared by either RF sputtering or laser ablation. The STM measurements
exhibit fairly uniform splitting size in [110] oriented areas on the order of
10 nm2 but vary from area to area, indicating some doping inhomogeneity. U and
V-shaped gaps were also observed, with good correspondence to the local
faceting, a manifestation of the dominant d-wave order parameter
Intelligence and neuroticism in relation to depression and psychological distress: Evidence from two large population cohorts
BACKGROUND: Neuroticism is a risk factor for selected mental and physical illnesses and is inversely associated with intelligence. Intelligence appears to interact with neuroticism and mitigate its detrimental effects on physical health and mortality. However, the inter-relationships of neuroticism and intelligence for major depressive disorder (MDD) and psychological distress has not been well examined. METHODS: Associations and interactions between neuroticism and general intelligence (g) on MDD, self-reported depression, and psychological distress were examined in two population-based cohorts: Generation Scotland: Scottish Family Health Study (GS:SFHS, n=19,200) and UK Biobank (n=90,529). The Eysenck Personality Scale Short Form-Revised measured neuroticism and g was extracted from multiple cognitive ability tests in each cohort. Family structure was adjusted for in GS:SFHS. RESULTS: Neuroticism was strongly associated with increased risk for depression and higher psychological distress in both samples. Although intelligence conferred no consistent independent effects on depression, it did increase the risk for depression across samples once neuroticism was adjusted for. Results suggest that higher intelligence may ameliorate the association between neuroticism and self-reported depression although no significant interaction was found for clinical MDD. Intelligence was inversely associated with psychological distress across cohorts. A small interaction was found across samples such that lower psychological distress associates with higher intelligence and lower neuroticism, although effect sizes were small. CONCLUSIONS: From two large cohort studies, our findings suggest intelligence acts a protective factor in mitigating the effects of neuroticism on psychological distress. Intelligence does not confer protection against diagnosis of depression in those high in neuroticism
Thermostatistics of deformed bosons and fermions
Based on the q-deformed oscillator algebra, we study the behavior of the mean
occupation number and its analogies with intermediate statistics and we obtain
an expression in terms of an infinite continued fraction, thus clarifying
successive approximations. In this framework, we study the thermostatistics of
q-deformed bosons and fermions and show that thermodynamics can be built on the
formalism of q-calculus. The entire structure of thermodynamics is preserved if
ordinary derivatives are replaced by the use of an appropriate Jackson
derivative and q-integral. Moreover, we derive the most important thermodynamic
functions and we study the q-boson and q-fermion ideal gas in the thermodynamic
limit.Comment: 14 pages, 2 figure
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