The NuMI Neutrino Beam and Potential for an Off-Axis Experiment

The Neutrinos at the Main Injector (NuMI) facility at Fermilab is under construction and due to begin operations in late 2004. NuMI will deliver an intense $\nu_{\mu}$ beam of variable energy 2-20 GeV directed into the Earth at 58 mrad. Several aspects of the design are reviewed, and potential limitations to the ultimate neutrino flux are described. In addition, potential measurements of neutrino mixing properties are described.Comment: talk given at NuFact '02, Imperial College London, proceedings to appear in J. Phys. G, revised to add a referenc

A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens

Development of personalised cancer models to predict response to radiation would benefit patient care; particularly in malignancies where treatment resistance is prevalent. Herein, a robust, easy to use, tumour-on-a-chip platform which maintains precision cut head and neck cancer for the purpose of ex vivo irradiation is described. The device utilises sintered discs to separate the biopsy and medium, mimicking in vivo microvascular flow and diffusion, maintaining tissue viability for 68 h. Integrity of tissues is demonstrated by the low levels of lactate dehydrogenase release and retained histology, accompanied by assessment of cell viability by trypan blue exclusion and flow cytometry; fluid dynamic modelling validates culture conditions. An irradiation jig is described for reproducible delivery of clinically-relevant doses (5 × 2 Gy) to newly-presenting primary tumours (n = 12); the addition of concurrent cisplatin is also investigated (n = 8) with response analysed by immunohistochemistry. Fractionated irradiation reduced proliferation (BrdU, p = 0.0064), increased DNA damage (ƴH2AX, p = 0.0043) and caspase-dependent apoptosis (caspase-cleaved cytokeratin-18) compared to control; caspase-dependent apoptosis was further increased by concurrent cisplatin compared to control (p = 0.0063). This is a proof of principle study showing the response of cancer tissue to irradiation ex vivo in a bespoke system. The novel platform described has the potential to personalise treatment for patients in a cost-effective manner with applicability to any solid tumour

Very Long Baseline Neutrino Oscillation Experiment for Precise Measurements of Mixing Parameters and CP Violating Effects

We analyze the prospects of a feasible, Brookhaven National Laboratory based, very long baseline (BVLB) neutrino oscillation experiment consisting of a conventional horn produced low energy wide band beam and a detector of 500 kT fiducial mass with modest requirements on event recognition and resolution. Such an experiment is intended primarily to determine CP violating effects in the neutrino sector for 3-generation mixing. We analyze the sensitivity of such an experiment. We conclude that this experiment will allow determination of the CP phase $\delta_{CP}$ and the currently unknown mixing parameter $\theta_{13}$, if $\sin ^2 2 \theta_{13} \geq 0.01$, a value $\sim 15$ times lower than the present experimental upper limit. In addition to $\theta_{13}$ and $\delta_{CP}$, the experiment has great potential for precise measurements of most other parameters in the neutrino mixing matrix including $\Delta m^2_{32}$, $\sin^2 2\theta_{23}$, $\Delta m^2_{21}\times \sin 2 \theta_{12}$, and the mass ordering of neutrinos through the observation of the matter effect in the $\nu_\mu \to \nu_e$ appearance channel.Comment: 12 pages, 10 figure

Neutrons from multiplicity-selected Au-Au collisions at 150, 250, 400, and 650 AMeV

We measured neutron triple-differential cross sections from multiplicity-selected Au-Au collisions at 150, 250, 400, and 650 \AMeV. The reaction plane for each collision was estimated from the summed transverse velocity vector of the charged fragments emitted in the collision. We examined the azimuthal distribution of the triple-differential cross sections as a function of the polar angle and the neutron rapidity. We extracted the average in--plane transverse momentum $\langle P_x\rangle$ and the normalized observable $\langle P_x/P_\perp\rangle$, where $P_\perp$ is the neutron transverse momentum, as a function of the neutron center-of-mass rapidity, and we examined the dependence of these observables on beam energy. These collective flow observables for neutrons, which are consistent with those of protons plus bound nucleons from the Plastic Ball Group, agree with the Boltzmann--Uehling--Uhlenbeck (BUU) calculations with a momentum--dependent interaction. Also, we calculated the polar-angle-integrated maximum azimuthal anisotropy ratio R from the value of $\langle P_x/P_\perp\rangle$.Comment: 20 LaTeX pages. 11 figures to be faxed on request, send email to sender's addres

Neutrons from multiplicity-selected La-La and Nb-Nb collisions at 400A MeV and La-La collisions at 250A MeV

Triple-differential cross sections for neutrons from high-multiplicity La-La collisions at 250 and 400 MeV per nucleon and Nb-Nb collisions at 400 MeV per nucleon were measured at several polar angles as a function of the azimuthal angle with respect to the reaction plane of the collision. The reaction plane was determined by a transverse-velocity method with the capability of identifying charged-particles with Z=1, Z=2, and Z > 2. The flow of neutrons was extracted from the slope at mid-rapidity of the curve of the average in-plane momentum vs the center-of-mass rapidity. The squeeze-out of the participant neutrons was observed in a direction normal to the reaction plane in the normalized momentum coordinates in the center-of-mass system. Experimental results of the neutron squeeze-out were compared with BUU calculations. The polar-angle dependence of the maximum azimuthal anisotropy ratio $r(\theta)$ was found to be insensitive to the mass of the colliding nuclei and the beam energy. Comparison of the observed polar-angle dependence of the maximum azimuthal anisotropy ratio $r(\theta)$ with BUU calculations for free neutrons revealed that $r(\theta)$ is insensitive also to the incompressibility modulus in the nuclear equation of state.Comment: ReVTeX, 16 pages, 17 figures. To be published in Physical Review

The energy dependence of flow in Ni induced collisions from 400 to 1970A MeV

We study the energy dependence of collective (hydrodynamic-like) nuclear matter flow in 400-1970 A MeV Ni+Au and 1000-1970 A MeV Ni+Cu reactions. The flow increases with energy, reaches a maximum, and then gradually decreases at higher energies. A way of comparing the energy dependence of flow values for different projectile-target mass combinations is introduced, which demonstrates a common scaling behaviour among flow values from different systems.Comment: 12 pages, 3 figures. Submitted to Physical Review Letter

Maximum Azimuthal Anisotropy of Neutrons from Nb-Nb Collisions at 400 AMeV and the Nuclear Equation of State

We measured the first azimuthal distributions of triple--differential cross sections of neutrons emitted in heavy-ion collisions, and compared their maximum azimuthal anisotropy ratios with Boltzmann--Uehling--Uhlenbeck (BUU) calculations with a momentum-dependent interaction. The BUU calculations agree with the triple- and double-differential cross sections for positive rapidity neutrons emitted at polar angles from 7 to 27 degrees; however, the maximum azimuthal anisotropy ratio for these free neutrons is insensitive to the size of the nuclear incompressibility modulus K characterizing the nuclear matter equation of state.Comment: Typeset using ReVTeX, with 3 ps figs., uuencoded and appende

Detectability of Strange Matter in Heavy Ion Experiments

We discuss the properties of two distinct forms of hypothetical strange matter, small lumps of strange quark matter (strangelets) and of hyperon matter (metastable exotic multihypernuclear objects: MEMOs), with special emphasis on their relevance for present and future heavy ion experiments. The masses of small strangelets up to A = 40 are calculated using the MIT bag model with shell mode filling for various bag parameters. The strangelets are checked for possible strong and weak hadronic decays, also taking into account multiple hadron decays. It is found that strangelets which are stable against strong decay are most likely highly negative charged, contrary to previous findings. Strangelets can be stable against weak hadronic decay but their masses and charges are still rather high. This has serious impact on the present high sensitivity searches in heavy ion experiments at the AGS and CERN facilities. On the other hand, highly charged MEMOs are predicted on the basis of an extended relativistic mean-field model. Those objects could be detected in future experiments searching for short-lived, rare composites. It is demonstrated that future experiments can be sensitive to a much wider variety of strangelets.Comment: 26 pages, 5 figures, uses RevTeX and epsf.st

High-throughput characterization, correlation, and mapping of leaf photosynthetic and functional traits in the soybean (Glycine max) nested association mapping population

Photosynthesis is a key target to improve crop production in many species including soybean [Glycine max (L.) Merr.]. A challenge is that phenotyping photosynthetic traits by traditional approaches is slow and destructive. There is proof-of-concept for leaf hyperspectral reflectance as a rapid method to model photosynthetic traits. However, the crucial step of demonstrating that hyperspectral approaches can be used to advance understanding of the genetic architecture of photosynthetic traits is untested. To address this challenge, we used full-range (500-2,400 nm) leaf reflectance spectroscopy to build partial least squares regression models to estimate leaf traits, including the rate-limiting processes of photosynthesis, maximum Rubisco carboxylation rate, and maximum electron transport. In total, 11 models were produced from a diverse population of soybean sampled over multiple field seasons to estimate photosynthetic parameters, chlorophyll content, leaf carbon and leaf nitrogen percentage, and specific leaf area (with R2 from 0.56 to 0.96 and root mean square error approximately \u3c10% of the range of calibration data). We explore the utility of these models by applying them to the soybean nested association mapping population, which showed variability in photosynthetic and leaf traits. Genetic mapping provided insights into the underlying genetic architecture of photosynthetic traits and potential improvement in soybean. Notably, the maximum Rubisco carboxylation rate mapped to a region of chromosome 19 containing genes encoding multiple small subunits of Rubisco. We also mapped the maximum electron transport rate to a region of chromosome 10 containing a fructose 1,6-bisphosphatase gene, encoding an important enzyme in the regeneration of ribulose 1,5-bisphosphate and the sucrose biosynthetic pathway. The estimated rate-limiting steps of photosynthesis were low or negatively correlated with yield suggesting that these traits are not influenced by the same genetic mechanisms and are not limiting yield in the soybean NAM population. Leaf carbon percentage, leaf nitrogen percentage, and specific leaf area showed strong correlations with yield and may be of interest in breeding programs as a proxy for yield. This work is among the first to use hyperspectral reflectance to model and map the genetic architecture of the rate-limiting steps of photosynthesis

Limited genetic parallels underlie convergent evolution of quantitative pattern variation in mimetic butterflies

Mimetic systems allow us to address the question of whether the same genes control similar phenotypes in different species. Although widespread parallels have been found for major effect loci, much less is known about genes that control quantitative trait variation. In this study, we identify and compare the loci that control subtle changes in the size and shape of forewing pattern elements in twoHeliconiusbutterfly co-mimics. We use quantitative trait locus (QTL) analysis with a multivariate phenotyping approach to map the variation in red pattern elements across the whole forewing surface ofHeliconius eratoandHeliconius melpomene. These results are compared with a QTL analysis of univariate trait changes, and show that our resolution for identifying small effect loci is somewhat improved with the multivariate approach, but also that different loci are detected with these different approaches. QTL likely corresponding to the known patterning geneoptixwere found in both species but otherwise, a remarkably low level of genetic parallelism was found. This lack of similarity indicates that the genetic basis of convergent traits may not be as predictable as assumed from studies that focus solely on Mendelian traits.Peer reviewe