Metal-NHC complexes: a survey of anti-cancer properties

International audienceNew weapons to fight cancer are constantly needed. Among chemotherapeutics, anti-cancer metal-drugs have enjoyed a long and successful history since the discovery of the benchmark cisplatin. Advances in metal-drug discovery have motivated chemists to build plethora of complex structures. Among them, a novel area is emerging. This article presents a survey of the metal-N-Heterocyclic Carbenes (Ag(I), Au(I), Pd(II) and Cu(I)-NHCs) as potential anti-cancer agents. Most of the metal-NHCs considered display higher cytotoxicities than the reference metallo-drug cisplatin. Some of them are even selective for particular cell lines. Their mechanisms of action at the cellular level are further discussed, showing that the nature of the metal is of great importance. All these promising results demonstrate that this approach deserves more attention and work

Journée sans culture : Troubler la fête, rallumer notre joie = To Spoil the Party, To Set Our Joy Ablaze

"Composed as an extension of the conversations that took place during the 2015 Journée sans culture, To Spoil the Party, to Set Our Joy Ablaze gathers contributions from those who moderated the discussions of the day as well as those who set up its sites of rest, reflection, and play. These authors work to remain true to the spirit of what they lived, led by the desire to find a source of collective energy that exceeds the pervasive effects of tiredness and resignation. Their texts are joined by others, commissioned by the editorial team, which explore matters of concern not sufficiently addressed during the day." -- Publisher's website

Biennale internationale d'estampe contemporaine de Trois-Rivières

Highlighting the first edition of an international event, this catalogue brings together 222 works by 38 printmakers representing 17 countries. To Desaulnier's presentation of how the event was organized, are added opinion texts by the jury members, as well as dossiers on the artists, which contain technical data, photographs of each work exhibited, and personal comments. Includes substantial documentation on Quebec's collective workshops (history, techniques and services). Biographical notes. 11 bibl. ref