La Comprensión Lectora y la Resolución de Problemas Algebraicos en Alumnos de Primer Año de Secundaria de una Institución Educativa Particular del Cercado de Lima

La presente investigación, de tipo descriptiva correlacional, permitió analizar la relación que existe entre la comprensión lectora y la resolución de problemas algebraicos en alumnos del primer año de secundaria de la Institución Educativa San Andrés Anglo Peruano, durante el año 2014. Para ello, se trabajó con una muestra de 62 alumnos de primer año de secundaria. Para medir el nivel de comprensión lectora de los alumnos, se les aplicó la Prueba de Complejidad Lingüística Progresiva (CLP 7 – FORMA A) de los autores Alliende, Condemarín y Milicic, adaptada por Delgado et al en el 2012. De la misma manera, para medir el nivel de resolución de problemas algebraicos de los estudiantes, se aplicó una prueba diseñada por la autora de la investigación, cuya validez de contenido fue obtenida a través de criterio de jueces y para su confiabilidad se utilizó el coeficiente de alfa de Cronbach. Para relacionar los puntajes de la comprensión lectora con los puntajes de la resolución de problemas algebraicos, se utilizó la prueba estadística de la correlación de Pearson, cuyos resultados demuestran la existencia de correlación estadísticamente significativa entre las variables comprensión lectora y resolución de problemas algebraicos.Tesi

Mechanisms involved in the remyelinating effect of sildenafil

Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease. Sildenafil, a cyclic GMP (cGMP)-specific phosphodiesterase 5 inhibitor (PDE5-I), is an oral vasodilator drug extensively used in humans for treatment of erectile dysfunction and pulmonary arterial hypertension. PDE5 is expressed in central nervous system (CNS) neuronal and glial populations and in endothelial cells and numerous studies in rodent models of neurological disease have evidenced the neuroprotective potential of PDE5-Is. Using myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) as a MS model, we previously showed that daily administration of sildenafil starting at peak disease rapidly ameliorates clinical symptoms while administration at symptoms onset prevents disease progression. These beneficial effects of the drug involved down-regulation of adaptive and innate immune responses, protection of axons and oligodendrocytes (OLs) and promotion of remyelination. In this work we have investigated mechanisms involved in the remyelinating effect of sildenafil. Using demyelinated organotypic cerebellar slice cultures we demonstrate that sildenafil stimulates remyelination by direct effects on CNS cells in a nitric oxide (NO)-cGMP-protein kinase G (PKG)-dependent manner. We also show that sildenafil treatment enhances OL maturation and induces expression of the promyelinating factor ciliary neurotrophic factor (CNTF) in spinal cord of EAE mice and in cerebellar slice cultures. Furthermore, we demonstrate that sildenafil promotes a M2 phenotype in bone marrow derived macrophages (BMDM) and increases myelin phagocytosis in these cells and in M2 microglia/macrophages in the spinal cord of EAE mice. Taken together these data indicate that promotion of OL maturation directly or through induction of growth factor expression, regulation of microglia/macrophage inflammatory phenotype and clearance of myelin debris may be relevant mechanisms involved in sildenafil enhancement of remyelination in demyelinated tissue and further support the contention that this well tolerated drug could be useful for ameliorating MS pathology

Ergonomic design applied in a sugar mill interface

In tasks requiring human supervision in an industrial control room there are applied generic disciplines like automatic control and engineering systems. From the point of view of the human computer interaction applied to these disciplines it is necessary to add usability engineering and cognitive ergonomics. This integrated framework is an example of human-centred design on automation systems. The main goal of this work is the application of a cognitive ergonomic guideline for supervisory control in order to improve the efficiency of a sugar mill interface design.Peer ReviewedPostprint (published version

An Evaluation of Serological Tests to Determine Postvaccinal Immunity to SARS-CoV-2 by mRNA Vaccines

[EN] Background: The duration of the protective efficacy of vaccines against SARS-CoV-2 is unknown. Thus, an evaluation of the clinical performance of available tests is required. Objectives: To evaluate the clinical performance of LFIA immunoassay compared to ELIA and CLIA immunoassays available in Europe for the detection of IgG antibodies generated by mRNA vaccines against SARS-CoV-2. Methods: Two automated immunoassays (the EUROIMMUN anti-SARS-CoV-2 IgG S1 ELISA and the LIAISON de Diasorin anti-SARS-CoV-2 IgG S1/S2 test) and a lateral flow immunoassay (the Livzon LFIA anti-SARS-CoV-2 IgG S test) were tested. We analyzed 300 samples distributed in three groups: 100 subjects aged over 18 years and under 45 years, 100 subjects aged between 45 and 65 years, and 100 subjects aged over 65 years. The samples were collected before vaccination; at 21 days; and then at 1, 2, 3, and 6 months after vaccination. The sensitivity, specificity, positive predictive value, negative predictive value, positive probability quotient, negative probability quotient, and concordance (kappa index) were calculated for each serological test. Results: The maximum sensitivity values for IgG were 98.7%, 98.1%, and 97.8% for the EUROIMMUN ELISA, Abbott CLIA, and Livzon LFIA tests, respectively, and the maximum specificity values for IgG were 99.4%, 99.9%%, and 98.4% for the ELISA, CLIA, and LFIA tests, respectively, at the third month after vaccination, representing a decrease in the antibody levels after the sixth month. The best agreement was observed between the ELISA and CLIA tests at 100% (k = 1.00). The agreement between the ELIA, CLIA, and LFIA tests was 99% (k = 0.964) at the second and third month after vaccination. Seroconversion was faster and more durable in the younger age groups. Conclusion: Our study examined the equivalent and homogeneous clinical performance for IgG of three immunoassays after vaccination and found LFIA to be the most cost-effective, reliable, and accurate for routine use in population seroconversion and seroprevalence studies.S

Generation of a human iPS cell line from a patient with retinitis pigmentosa due to EYS mutation

Retinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal recessive RP. The human iPS cell line, CABi002-A, derived from peripheral blood mononuclear cells from a patient carrying a heterozygous double mutation in EYS gene was generated by non-integrative reprogramming technology, using hOCT3/4, hSOX2, hc-MYC and hKLF4 reprogramming factors. Pluripotency and differentiation capacity were assessed by immunocytochemistry and RT-PCR. This iPSC line can be further differentiated towards the affected cells to understand the pathophysiology of the disease and test new therapeutic strategies.Cellex FoundationFundación Progreso y Salu

Emulsion characteristics of salad dressings as affected by caprine whey protein concentrates

Caprine whey protein concentrates (WPC) were incorporated as emulsifiers in a salad dressing. The concentrates were manufactured by ultrafiltration-diafiltration with or without previous clarification by thermocalcic precipitation. Aggregates obtained in the clarification treatment and a commercial bovine WPC were also used as emulsifiers. Good emulsifying properties of caprine products were observed. Dressings made with caprine products showed higher firmness and stability than dressings made with bovine WPC. Thermocalcic precipitation improved the properties of caprine WPC. Aggregates modified the colour of dressings contributing to a more yellowish aspect. Microstructure of emulsions was affected by the type of proteinThe authors thank the Xunta de Galicia (Galicia, Spain), GPC 2016/008 for financial supportS

Caracterización de la carne de dos aves de caza: zorzal (Turdus philomelos) y tórtola (Streptopelia turtur)

The chemical and fatty acid composition and color of wild thrush (Turdus philomelos) and turtle dove (Streptopelia turtur) meat were investigated. No significant differences in the chemical composition were observed between the meat of thrush and that of turtle dove. However, significant differences (p < 0.05) in the fatty acid composition of the three fractions (glycerides, phospholipids, and free fatty acids) and in color parameters were observed. The main fatty acid in thrush meat was oleic acid (around 30%), and the high content of docosahexaenoic acid (C-22:6n-3) (more than 10% in the three fractions) was remarkable. There was a high content of polyunsaturated fatty acids (PUFA) (more than 50%) in the turtle dove meat; the main PUFA were linoleic (C-18:2n-6) and arachidonic (C-20:4n-6) acidsSe ha estudiado la composición química, de ácidos grasos y el color de la carne de zorzal (Turdus philomelos) y tórtola (Streptopelia turtur). No se observaron diferencias significativas en la composición química entre la carne de ambas especies; sin embargo, sí se detectaron diferencias significativas (p < 0,05) en la composición de ácidos grasos de las tres fracciones lipídicas (glicéridos, fosfolípidos y ácidos grasos libres) y en los parámetros de color. El principal ácido graso en la carne de zorzal fue el ácido oleico (alrededor del 30%), siendo remarcable el alto contenido de ácido docosahexaenoico (C-22:6n-3) (mayor del 10% en las tres fracciones). La carne de tórtola presentó un alto contenido de ácidos grasos poliinsaturados (mayor del 50%), siendo los principales ácidos grasos poliinsaturados el linoleico (C-18:2n-6) y el araquidónico (C-20:4n-6)S

Occupational Stress in Spanish Police Officers: Validating the Effort-Reward Imbalance Questionnaire

The Effort-Reward Imbalance Questionnaire (hereinafter, ERIQ) has been largely used worldwide to assess job stress, but it has not yet been applied in Spanish police. The objective of this study was to examine the construct validity and the internal consistency of the ERIQ in police officers. A cross-sectional study was carried out, using a nonprobability sampling (quota). A total of 217 Spanish police officers participated, 192 men (88.47%) and 25 women (11.53%). The mean age was 41 years (SD = 7.51). These police officers completed the ERIQ together with some other questionnaires (DECORE-21, MBI, GHQ and STAI) in order to provide evidence for validity based on the relationships to other constructs. A confirmatory factor analysis was performed and a matrix of correlations with the rest of constructs was created. The results showed an appropriate fit to the original model consisting of three scales. In addition, the scales of the ERIQ presented the expected relationship with the other constructs. The ERIQ is a valid instrument for assessing occupational stress in Spanish police officers and can improve the interventions in this professional group.Depto. de Psicología Social, del Trabajo y DiferencialFac. de PsicologíaTRUEpu