Warped Kaluza-Klein Dark Matter

Warped compactifications of type IIB string theory contain natural dark matter candidates: Kaluza-Klein modes along approximate isometry directions of long warped throats. These isometries are broken by the full compactification, including moduli stabilization; we present a thorough survey of Kaluza-Klein mode decay rates into light supergravity modes and Standard Model particles. We find that these dark matter candidates typically have lifetimes longer than the age of the universe. Interestingly, some choices for embedding the Standard Model in the compactification lead to decay rates large enough to be observed, so this dark matter sector may provide constraints on the parameter space of the compactification.Comment: 37pp; v2. references, minor clarificatio

N=4 Supergravity Lagrangian for Type IIB Orientifold on T^6/Z_2 in Presence of Fluxes and D3-Branes

We derive the Lagrangian and the transformation laws of N=4 gauged supergravity coupled to matter multiplets whose sigma-model of the scalars is SU(1,1)/U(1)x SO(6,6+n)/SO(6)xSO(6+n) and which corresponds to the effective Lagrangian of the Type IIB string compactified on the T^6/Z_2 orientifold with fluxes turned on and in presence of n D3-branes. The gauge group is T^12 x G where G is the gauge group on the brane and T^12 is the gauge group on the bulk corresponding to the gauged translations of the R-R scalars coming from the R-R four--form. The N=4 bulk sector of this theory can be obtained as a truncation of the Scherk-Schwarz spontaneously broken N=8 supergravity. Consequently the full bulk spectrum satisfies quadratic and quartic mass sum rules, identical to those encountered in Scherk-Schwarz reduction gauging a flat group. This theory gives rise to a no scale supergravity extended with partial super-Higgs mechanism.Comment: 49 pages, LaTex, 2 figures. Misprints corrected, more comments adde

4-D gauged supergravity analysis of Type IIB vacua on K3×T2/Z2K3\times T^2/Z_2

We analyze $N=2,1,0$ vacua of type IIB string theory on $K3\times T^2/Z_2$ in presence of three-form fluxes from a four dimensional supergravity viewpoint. The quaternionic geometry of the $K3$ moduli space together with the special geometry of the NS and R-R dilatons and of the $T^2$-complex structure moduli play a crucial role in the analysis. The introduction of fluxes corresponds to a particular gauging of N=2, D=4 supergravity. Our results agree with a recent work of Tripathy and Trivedi. The present formulation shows the power of supergravity in the study of effective theories with broken supersymmetry.Comment: AMS-LaTeX, 29 page

The role of citizen science in addressing grand challenges in food and agriculture research

The power of citizen science to contribute to both science and society is gaining increased recognition, particularly in physics and biology. Although there is a long history of public engagement in agriculture and food science, the term ‘citizen science’ has rarely been applied to these efforts. Similarly, in the emerging field of citizen science, most new citizen science projects do not focus on food or agriculture. Here, we convened thought leaders from a broad range of fields related to citizen science, agriculture, and food science to highlight key opportunities for bridging these overlapping yet disconnected communities/fields and identify ways to leverage their respective strengths. Specifically, we show that (i) citizen science projects are addressing many grand challenges facing our food systems, as outlined by the United States National Institute of Food and Agriculture, as well as broader Sustainable Development Goals set by the United Nations Development Programme, (ii) there exist emerging opportunities and unique challenges for citizen science in agriculture/food research, and (iii) the greatest opportunities for the development of citizen science projects in agriculture and food science will be gained by using the existing infrastructure and tools of Extension programmes and through the engagement of urban communities. Further, we argue there is no better time to foster greater collaboration between these fields given the trend of shrinking Extension programmes, the increasing need to apply innovative solutions to address rising demands on agricultural systems, and the exponential growth of the field of citizen science.This working group was partially funded from the NCSU Plant Sciences Initiative, College of Agriculture and Life Sciences ‘Big Ideas’ grant, National Science Foundation grant to R.R.D. (NSF no. 1319293), and a United States Department of Food and Agriculture-National Institute of Food and Agriculture grant to S.F.R., USDA-NIFA Post Doctoral Fellowships grant no. 2017-67012-26999.http://rspb.royalsocietypublishing.orghj2018Forestry and Agricultural Biotechnology Institute (FABI

Intoxicação por monofluoroacetato em animais

O monofluoroacetato (MF) ou ácido monofluoroacético é utilizado na Austrália e Nova Zelândia no controle populacional de mamíferos nativos ou exóticos. O uso desse composto é proibido no Brasil, devido ao risco de intoxicação de seres humanos e de animais, uma vez que a substância permanece estável por décadas. No Brasil casos recentes de intoxicação criminosa ou acidental têm sido registrados. MF foi identificado em diversas plantas tóxicas, cuja ingestão determina "morte súbita"; de bovinos na África do Sul, Austrália e no Brasil. O modo de ação dessa substância baseia-se na formação do fluorocitrato, seu metabólito ativo, que bloqueia competitivamente a aconitase e o ciclo de Krebs, o que reduz produção de ATP. As espécies animais têm sido classificadas nas quatro Categorias em função do efeito provocado por MF: (I) no coração, (II) no sistema nervoso central (III) sobre o coração e sistema nervoso central ou (IV) com sintomatologia atípica. Neste trabalho, apresenta-se uma revisão crítica atualizada sobre essa substância. O diagnóstico da intoxicação por MF é realizado pelo histórico de ingestão do tóxico, pelos achados clínicos e confirmado por exame toxicológico. Uma forma peculiar de degeneração hidrópico-vacuolar das células epiteliais dos túbulos uriníferos contorcidos distais tem sido considerada como característica dessa intoxicação em algumas espécies. O tratamento da intoxicação por MF é um desafio, pois ainda não se conhece um agente capaz de reverte-la de maneira eficaz; o desfecho geralmente é fata

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Separation algorithms for 0-1 knapsack polytopes

Valid inequalities for 0-1 knapsack polytopes often prove useful when tackling hard 0-1 Linear Programming problems. To generate such inequalities, one needs separation algorithms for them, i.e., routines for detecting when they are violated. We present new exact and heuristic separation algorithms for several classes of inequalities, namely lifted cover, extended cover, weight and lifted pack inequalities. Moreover, we show how to improve a recent separation algorithm for the 0-1 knapsack polytope itself. Extensive computational results, on MIPLIB and OR Library instances, show the strengths and limitations of the inequalities and algorithms considered