Household chemicals and pre-schoolers: Caretakers’ beliefs and perspectives on risks and responsibilities

Chemical products are present in most households and can endanger the health of humans, particularly toddlers and pre-school children. With a focus on accident prevention, this article investigates parents and other caretakers’ beliefs and perspectives on risks and responsibilities. A mixed method approach was applied, combining in-depth qualitative interviews (pre-study, N = 10) and a quantitative survey (main study, N = 688) with Swiss caretakers of pre-school children. The questionnaire of the main study was developed based on the findings from the pre-study, and measured beliefs, perceptions of product, environmental risks, and responsibilities. The main findings suggest some prevalent misconceptions among parents regarding the risks of products perceived to be natural and the safety of child-protective caps. Furthermore, relationships were uncovered between psychological factors, such as perceived responsibility, trust and risk perception, and caretakers’ beliefs about household chemicals and their role in accident prevention. These beliefs highlight the need for preventive efforts focused on caretakers exhibiting pragmatic/trusting beliefs, compared to caretakers exhibiting protective or educational beliefs

Seeing household chemicals through the eyes of children—Investigating influential factors of preschoolers’ perception and behavior

Introduction: Children who encounter household chemicals run the risk of unintentional injury. The aim of this study was to understand which factors heighten children’s attention or misguide their decision-making concerning household chemicals. We hypothesized that certain product attributes (i.e., label, packaging, closure types), storage context, and parental beliefs play a role in this setting. Method: We conducted a laboratory study with N = 114 children (M = 45 months, SD = 6.5) and their parents (M = 38 years, SD = 4.92). Children completed a series of behavioral tasks in which they had to choose between products with different attributes, identify products in different storage contexts, and sort household chemicals. Results: The results confirmed that the children preferred products with cartoon-style labels compared to products without such labels. However, children’s decision-making did not differ for products with different closure types (child-resistant vs sprayer-type closures). Regarding the storage context, our results showed that the children particularly struggled to identify dishwashing tabs when they were stored with other food items rather than household chemicals. In terms of parental beliefs, our study found that parents rated more household chemicals as child-safe than their children did. Practical Application: Parents should buy household chemicals with neutral labels and pay attention to how their household chemicals are stored. Manufacturers should consider potential adverse effects when developing new product designs

Childhood poisonings: Effects of ambiguous product characteristics on preschool children's categorization of household chemicals

This study investigated preschool children's categorization and risk perception of products with ambiguous product characteristics (e.g., food‐like packaging). These characteristics make it difficult for preschool children to categorize household chemicals correctly. This, therefore, increases the risk of unintentional poisoning. We hypothesized that ambiguity arises from different product characteristics, such as the type of packaging, the products’ scent, or the packaging's color and transparency. In four behavioral tasks, N = 108 preschool children (M = 43 months, SD = 3) categorized different products and household chemicals with various types of packaging, colors, and scents. Individually wrapped dishwasher tablets were more likely to be categorized as edible than unwrapped ones. Furthermore, children who had interacted with any type of dishwasher tablet in the last 6 months performed better in identifying dishwasher tablets, regardless of packaging type. Household chemicals with a fruity scent were more likely to be categorized as drinkable than those with a chlorine scent. Finally, the children considered black bottles more dangerous and preferred them less than bottles of a different color. In contrast, bottle transparency generally did not seem to affect risk perception and preference. These findings confirm that ambiguous product characteristics influence children's categorization of unknown products and, thus, their risk perception and decision‐making. Manufacturers and caregivers are advised to reduce the ambiguity of household chemicals by designing more neutral product packaging and choosing products with more neutral elements, respectively

When information security depends on font size : how the saliency of warnings affects protection behavior

Prior research on how to improve the effectiveness of information security warnings has predominantly focused on either the informational content of warnings or their visual saliency. In an online experiment (N?=?1’486), we disentangle the effect of both manipulations and demonstrate that both factors simultaneously influence decision making. Our data indicate that the proportion of people who engage in protection behavior can be increased by roughly 65% by making a particular warning message more visually salient (i.e. a more conspicuous visual design is used). We also show that varying the message’s saliency can make people behave very differently when confronted with the same threat or behave very similarly when confronted with threats that differ widely in terms of severity of outcomes. Our results suggest that the visual design of a warning may warrant at least as much attention as the informational content that the warning message conveys

Avoiding unintentional injuries from household chemicals: Comparing the appeal to children from the perspectives of children, caregivers, and experts

This study investigated whether caregivers and regulatory experts can predict the appeal of household chemicals for children and explored determinants of differences between adults' and children's child-appeal rating. We invited N = 95 4-year-old children and their caregivers to a laboratory study. Both independently ranked 16 household chemicals from the least to the most child-appealing product. In addition to the laboratory study, we sent an online adaptation of this ranking task to N = 46 experts involved in the monitoring and authorizing of household chemicals. Our findings show that the aggregated child-appeal rating of household chemicals was highly similar among caregivers, experts, and children. When comparing child-appeal ratings of household chemicals with and without child-appealing images, caregivers and experts did well in predicting which products might appeal to children. Finally, our findings show that the similarity between individual caregivers' and their own children's child-appeal ratings of household chemicals varied substantially. To conclude, although adults can assess the general child-appeal of household chemicals, they need to consider that the actual appeal of a household chemical can vary considerably among individual children. Instead of regulating specific product attributes, policymakers should prioritize educating caregivers about pitfalls and misconceptions that hinder effective injury prevention

Data recording and use of data tools for pig health management: perspectives of stakeholders in pig farming

Introduction: Data-driven strategies might combat the spreading of infectious pig disease and improve the early detection of potential pig health problems. The current study aimed to explore individual views on data recording and use of data tools for pig health management by recruiting stakeholders (N = 202) in Spain, Ireland, and the Netherlands. Methods: Questionnaire focused on current on-farm challenges, current status of data recording on farms, and evaluation of the two mock data tools. Particularly, “benchmarking tool” was designed to visualize individual farm’s pig mortality, targeting the management of infectious respiratory and gastrointestinal diseases; and “early-warning tool” was designed to generate an alarm through monitoring coughs in pigs, targeting the management of infectious respiratory diseases. Results: Results showed that respiratory and gastrointestinal diseases and aggressive behaviors were the most frequently mentioned health challenge and welfare challenge, respectively. Most of the data was more frequently recorded electronically than on paper. In general, the “benchmarking tool” was perceived as useful for the management of infectious respiratory and gastrointestinal diseases, and the “early-warning tool” was evaluated as useful for the management of infectious respiratory diseases. Several barriers to the perceived usefulness of these two tools were identified, such as the lack of contextual information, inconvenience of data input, limited internet access, reliance on one’s own experience and observation, technical hurdles, and mistrust of information output. The perceived usefulness of both tools was higher among highly educated participants, and those who reported being integrators and positive toward technology for disease control. Female participants and those who came from integrated farms evaluated the “early-warning tool” as more useful compared to their counterparts. The perceived usefulness of the “early-warning tool” was negatively affected by age and work experience, but positively affected by extensiveness of data recording, positive attitude toward technology, and the current use of technology. Discussion: In summary, participants showed optimistic views on the use of data tools to support their decision-making and management of infectious pig respiratory and gastrointestinal diseases. It is noteworthy that data tools should not only convey the value of data for informed decision-making but also consider stakeholders’ preconditions and needs for data tools.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This project was funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 101000494.info:eu-repo/semantics/publishedVersio

New approach methodologies in human health risk assessment across European regulatory frameworks:Status quo, barriers and drivers for regulatory acceptance and use

The traditional approaches to chemical risk assessment for human health are continuously challenged by their limitations, such as validity concerns, societal pressure to use animal-free methods, and resource constraints. New Approach Methodologies (NAMs) are considered a promising avenue toward modernisation of chemical risk assessment practices but their implementation in practice has been slow. This article aims to investigate the perspectives of human health risk assessors on the status quo, barriers and drivers of the acceptance and use of NAMs across different regulatory frameworks. A mixed method design was applied: qualitative interviews (N = 19) and an online survey with human health risk assessors from industry, regulatory agencies/institutions and academia (N = 222). The results show heterogeneity in familiarity and use of specific NAMs (e.g., QSARs as well-known and used vs. −omics approaches that are seldom used), the risk assessors’ background (e.g., industry vs. regulatory agencies and institutions vs. academia) and the application context (e.g., screening/prioritisation vs. hazard identification/characterisation). The identified barriers and drivers offer pointers for the future integration and acceptance of NAMs in regulatory risk assessment. For instance, guidance documents can facilitate the use of NAMs, showcasing successful examples that increase trust in the methods and thus, the risk assessors’ confidence in using these methods. Among other things, the article highlights the importance of considering human health risk assessors’ needs and prerequisites to foster bottom-up coordinated efforts and to ensure the success of top-down legal and institutional change to incorporate NAMs in regulatory risk assessment

How do pig veterinarians view technology-assisted data utilisation for pig health and welfare management? A qualitative study in Spain, the Netherlands, and Ireland

Background Application of data-driven strategies may support veterinarians’ decision-making, benefitting pig disease prevention and control. However, little is known about veterinarians’ need for data utilisation to support their decision-making process. The current study used qualitative methods, specifically focus group discussions, to explore veterinarians’ views on data utilisation and their need for data tools in relation to pig health and welfare management in Spain, the Netherlands, and Ireland. Results Generally, veterinarians pointed out the potential benefits of using technology for pig health and welfare management, but data is not yet structurally available to support their decision-making. Veterinarians pointed out the challenge of collecting, recording, and accessing data in a consistent and timely manner. Besides, the reliability, standardisation, and the context of data were identified as important factors affecting the efficiency and effectiveness of data utilisation by veterinarians. A user-friendly, adaptable, and integrated data tool was regarded as potentially helpful for veterinarians’ daily work and supporting their decision-making. Specifically, veterinarians, particularly independent veterinary practitioners, noted a need for easy access to pig information. Veterinarians such as those working for integrated companies, corporate veterinarians, and independent veterinary practitioners expressed their need for data tools that provide useful information to monitor pig health and welfare in real-time, to visualise the prevalence of endemic disease based on a shared report between farmers, veterinarians, and other professional parties, to support decision-making, and to receive early warnings for disease prevention and control. Conclusions It is concluded that the management of pig health and welfare may benefit from data utilisation if the quality of data can be assured, the data tools can meet veterinarians’ needs for decision-making, and the collaboration of sharing data and using data between farmers, veterinarians, and other professional parties can be enhanced. Nevertheless, several notable technical and institutional barriers still exist, which need to be overcome.Open access funding provided by Swiss Federal Institute of Technology Zurich. This study is part of DECIDE project which has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 101000494.info:eu-repo/semantics/publishedVersio

Exploring experiences of the regulatory toxicology system:system‑level promoters and inhibitors of new approach methodologies

The transition from traditional animal-based approaches and assessments to New Approach Methodologies (NAMs) marks a scientific revolution in regulatory toxicology, with the potential of enhancing human and environmental protection. However, implementing the effective use of NAMs in regulatory toxicology has proven to be challenging, and so far, efforts to facilitate this change frequently focus on singular technical, psychological or economic inhibitors. This article takes a system-thinking approach to these challenges, a holistic framework for describing interactive relationships between the components of a system of interest. In this case, the regulatory toxicology system. We do so by analysing and interpreting a very large qualitative data set of experts’ observations, collected in a 3-day interactive workshop and three follow-up online workshops with a heterogeneous sample of experts representing major actors from the global regulatory toxicology system. We identified leverage points (where a small change within a system can have a disproportionately large effect) in the six core aspects—infrastructure, processes, culture, technology, goals, and actors—in the regulatory toxicology system to facilitate the effective use of NAMs. Identified systematic leverage points include the need for a functioning incentive structure for effectively discovering, developing, validating and using NAMs within academia, regulation, and industry; and measures that prevent or mitigate unwanted effects of using NAMs that acknowledge clashes between scientific, regulatory, political and social processes. The results serve as a basis for follow-up activities that reflect on the actual effectiveness of these levers and that develop measures for the regulatory toxicology system

Risks to human and animal health from the presence of bromide in food and feed

The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. The critical effects of bromide in experimental animals are on the thyroid and central nervous system. Changes in thyroid hormone homeostasis could result in neurodevelopmental toxicity, among other adverse effects. Changes in thyroid hormone concentrations and neurophysiological parameters have also been observed in experimental human studies, but the evidence was limited. Dose–response modelling of decreased blood thyroxine concentrations in rats resulted in a reference point of 40 mg/kg body weight (bw) per day. The Scientific Committee established a tolerable daily intake (TDI) of 0.4 mg/kg bw per day and an acute reference dose (ARfD) of 0.4 mg/kg bw per day to protect against adverse neurodevelopmental effects. The TDI value is supported by the results of experimental human studies with a NOAEL of 4 mg/kg bw per day and 10-fold interindividual variability. The TDI and ARfD are considered as conservative with 90% certainty. Insufficient evidence related to the toxicological effects of bromide was available for animals, with the exception of dogs. Therefore, the reference point of 40 mg/kg bw per day was extrapolated to maximum safe concentrations of bromide in complete feed for other animal species. Bromide can transfer from feed to food of animal origin, but, from the limited data, it was not possible to quantify the transfer rate. Monitoring data exceeded the current MRLs for some food commodities, generally with a low frequency. A conservative safety screening of the MRLs indicated that the TDI and ARfD are exceeded for some EU diets. Dietary exposure assessment for animals was not feasible due to insufficient data. The Scientific Committee recommends data be generated to allow robust dietary exposure assessments in the future, and data that support the risk assessment