840 research outputs found
An Ecological and Evolutionary Framework for Commensalism in Anthropogenic Environments
Acknowledgements We would like to thank Jean-Denis Vigne, members of the Searle lab, and SNEEB at Cornell University for a stimulating environment and many early discussions and comments. We would also like to thank Maeve McMahon for comments on the manuscript.Peer reviewedPublisher PD
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Support-Free Infiltration of Selective Laser Sintered (SLS) Silicon Carbide Preforms
Non-metallic objects are often difficult to manufacture due to high melting temperatures,
poor sinterability, limited ductility, and difficulty in machining. Freeform fabrication techniques
coupled with liquid infiltration offer a cost-effective and rapid manufacturing mechanism for
composite parts with complex geometry and adequate properties. Selective laser sintered (SLS)
silicon carbide (SiC) preforms infiltrated with liquid silicon develop localized infiltrant overextrusions onto surfaces and at surface irregularities. Several shrinkage mechanisms including
densification were studied as possible causes of these overfilling extrusions, and the results are
discussed below. This research was supported by NSF Grant Number DMI-0522176.Mechanical Engineerin
Chromosome Complements in Desmanthus (Leguminosae)
Desmanthus, a genus of the subfamily Mimosoideae of the Leguminosae, is represented in the United States by ten species, one of which has two varieties. Nine species are found in Texas (Turner, 1950b). The genus has its greatest concentration in Mexico where sixteen species occur (Turner, 1950a). In the present paper chromosome studies on Desmanthus acuminatus, D. brevipes, D. leptolobus, D. velutinus and D. virgatus var. depressus are reported. These five species occur in Texas
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Contrasting effects of changing rhythm and content on auditory distraction in immediate memory
Across five experiments, the temporal regularity and content of an irrelevant speech stream were varied and their effects on a serial recall task examined. Variations of the content, but not the rhythm, of the irrelevant speech stimuli reliably disrupted serial recall performance in all experiments. Bayesian analyses supported the null hypothesis over the hypothesis that irregular rhythms would disrupt memory to a greater extent than regular rhythms. Pooling the data in a combined analysis revealed that regular presentation of the irrelevant speech was significantly more disruptive to serial recall than irregular presentation. These results are consistent with the idea that auditory distraction is sensitive to both intra-item and inter-item relations and challenge an orienting-based account of auditory distraction
Sperm competition as an under-appreciated factor in domestication
Humans created an environment that increased selective pressures on subgroups of those species that became domestic. We propose that the domestication process may in some cases have been facilitated by changes in mating behaviour and resultant sperm competition. By adapting to sperm competition, proto-domestic animals could potentially have outcompeted their wild counterparts in human-constructed niches. This could have contributed to the restriction of gene flow between the proto-domesticates and their wild counterparts, thereby promoting the fixation of other domestication characteristics. Further to this novel perspective for domestication, we emphasise the general potential of postcopulatory sexual selection in the restriction of gene flow between populations, and urge more studies
Measuring linguistic complexity in long-term L2 speakers of English and L1 attriters of German
Linguistic complexity is neither easily defined nor measured. The challenge in finding reliable ways to measure linguistic complexity is even more pronounced when the variation of contexts in which complexity is measured is taken into account. This paper therefore aims at finding measures for assessing syntactic and lexical complexity that are sensitive and non-overlapping even in a less frequently studied context: spontaneous speech of L1 attriters and highly proficient L2 English speakers.
To evaluate operationalizations of syntactic and lexical complexity, several previously proposed measures are applied to a corpus of spontaneous speech and a principal component analysis is conducted. The results show which of the measures group together as underlying variables of syntactic and lexical complexity and how this can inform future operationalizations of complexity
Changing Landscapes for the Third Sector: Enhancing Knowledge and Informing Practice. Report on the Timescapes Archive.
The broad aim of the Changing Landscapes project, as set out in the proposal to ESRC, was “to bring together a body of qualitative longitudinal and life course research on the third sector in order to exchange knowledge and data of relevance to the future development of the sector”. Underpinning this aim is the Timescapes Archive – a specialist archive of Qualitative Longitudinal (QL) data for sharing and re-use. The long term strategy for the archive is to build collections of thematically related QL datasets, including non ESRC funded datasets, in order to facilitate data discovery and secondary analysis across a range of substantive topics. This is in a context where QL methodology is fast advancing and a growing number of projects are being funded. The archive originally contained a collection of 9 datasets (Changing Relationships and Identities through the Life Course - short hand title, Changing Relationships and Identities). Under the new funding, the aim was to develop a new collection of datasets (Changing Landscapes for the Third Sector). The specific objective was to “prepare data from two complementary datasets (NCVO and Birmingham) and ingest the data into the Timescapes Archive” (ESRC proposal). This report describes the work undertaken in order to achieve the objective of adding two datasets to the Timescapes Archive, but also details the important development work undertaken to establish the Timescapes Archive on a new technical platform which will support the long term strategy for the Archive and ensure that the Archive is aligned with the University of Leeds institutional data management provision
GeoOrigins: A new method and R package for trait mapping and geographic provenancing of specimens without categorical constraints
Biologists often seek to geographically provenance organisms using their traits. This is typically achieved by defining spatial groups using distinct patterns of trait variation. Here, we present a new spatial provenancing and trait boundary identification methodology, based on correlations between geographic and trait distances that require no a priori group assumptions. We apply this to three datasets where spatial provenance is sought: morphological rat and vole dentition data (human commensal translocation datasets); and birdsong data (cultural transmission dataset). We also present the results of cross‐validation testing. Spatial provenancing is possible with differing degrees of accuracy for each dataset, with birdsong providing the most accurate geographic origin (identifying an average spatial region of 0.22 km2 as the area of origin with 99.9% confidence). Our method has a wide range of potential applications to diverse data types—including phenotypic, genetic and cultural—to identify trait boundaries and spatially provenance the origin of unknown or translocated specimens where trait differences are geographically structured and correlated with spatial separation
Experimental Granulomatous Pulmonary Nocardiosis in BALB/C Mice
Pulmonary nocardiosis is a granulomatous disease with high mortality that affects both immunosuppressed and immunocompetent patients. The mechanisms leading to the establishment and progression of the infection are currently unknown. An animal model to study these mechanisms is sorely needed. We report the first in vivo model of granulomatous pulmonary nocardiosis that closely resembles human pathology. BALB/c mice infected intranasally with two different doses of GFP-expressing Nocardia brasiliensis ATCC700358 (NbGFP), develop weight loss and pulmonary granulomas. Mice infected with 109 CFUs progressed towards death within a week while mice infected with 108 CFUs died after five to six months. Histological examination of the lungs revealed that both the higher and lower doses of NbGFP induced granulomas with NbGFP clearly identifiable at the center of the
lesions. Mice exposed to 108 CFUs and subsequently to 109 CFUs were not protected against disease severity but had less granulomas suggesting some degree of protection.
Attempts to identify a cellular target for the infection were unsuccessful but we found that bacterial microcolonies in the suspension used to infect mice were responsible for the establishment of the disease. Small microcolonies of NbGFP, incompatible with nocardial
doubling times starting from unicellular organisms, were identified in the lung as early as six hours after infection. Mice infected with highly purified unicellular preparations of NbGFP did not develop granulomas despite showing weight loss. Finally, intranasal delivery of
nocardial microcolonies was enough for mice to develop granulomas with minimal weight loss. Taken together these results show that Nocardia brasiliensis microcolonies are both necessary and sufficient for the development of granulomatous pulmonary nocardiosis in mice
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