Simulation of the fluctuating field of a forced jet

The fluctuating field of a jet excited by transient mass injection is simulated numerically. The model is developed by expanding the state vector as a mean state plus a fluctuating state. Nonlinear terms are not neglected and the effect of nonlinearity is studied. The results show a significant spectral broadening in the flow field due to the nonlinearity. In addition, large scale structures are broken down into smaller scales

Stability and control of compressible flows over a surface with concave-conves curvature

The active control of spatially unstable disturbances in a laminar, two-dimensional, compressible boundary layer over a curved surface is numerically simulated. The control is effected by localized time-periodic surface heating. We consider two similar surfaces of different heights with concave-convex curvature. In one, the height is sufficiently large so that the favorable pressure gradient is sufficient to stabilize a particular disturbance. In the other case the pressure gradient induced by the curvature is destabilizing. It is shown that by using active control that the disturbance can be stabilized. The results demonstrate that the curvature induced mean pressure gradient significantly enhances the receptivity of the flow localized time-periodic surface heating and that this is a potentially viable mechanism in air

On the interaction of a sound pulse with the shear layer of an axisymmetric jet. Part 3: Nonlinear effects

The fluctuating field of a jet excited by transient mass injection is simulated numerically. The model is developed by expanding the state vector as a mean state plus a fluctuating state. Nonlinear terms are not neglected, and the effect of nonlinearity was studied. A high order numerical method is used to compute the solution. The results show a significant spectral broadening in the flow field due to the nonlinearity. In addition, large scale structures are broken down into smaller scales

Experimental and numerical results on a shear layer excited by a sound pulse

The behavior of a sound in a jet was investigated. It is verified that the far-field acoustic power increased with flow velocity for the lower and medium frequency range. Experimentally, an attenuation at higher frequencies is also observed. This increase is found numerically to be due primarily to the interactions between the mean vorticity and the fluctuation velocities. Spectral decomposition of the real time data indicates that the power increase occurs in the low and middle frequency range, where the local instability waves have the largest spatial growth rate. The connection between this amplification and the local instability waves is discussed

Active control of compressible flows on a curved surface

The effect of localized, time periodic surface heating and cooling over a curved surface is studied. This is a mechanism for the active control of unstable disturbances by phase cancellation and reinforcement. It is shown that the pressure gradient induced by the curvature significantly enhances the effectiveness of this form of active control. In particular, by appropriate choice of phase, active surface heating can completely stabilize and unstable wave

Numerical simulation of boundary layer excitation by surface heating/cooling

The concept of active control of growing disturbances in an unstable compressible flow by using time periodic, localized surface heating is studied numerically. The simulations are calculated by a fourth-order accurate solution of the compressible, laminar Navier-Stokes equations. Fourth-order accuracy is particularly important for this problem because the solution must be computed over many wavelengths. The numerical results demonstrate the growth of an initially small fluctuation into the nonlinear regime where a local breakdown into smaller scale disturbances can be observed. It is shown that periodic surface heating over a small strip can reduce the level of the fluctuation provided that the phase of the heating current is properly chosen

Star Formation at z=2.481 in the Lensed Galaxy SDSS J1110+6459, I: Lens Modeling and Source Reconstruction

Using the combined resolving power of the Hubble Space Telescope and gravitational lensing, we resolve star-forming structures in a z~2.5 galaxy on scales much smaller than the usual kiloparsec diffraction limit of HST. SGAS J111020.0+645950.8 is a clumpy, star forming galaxy lensed by the galaxy cluster SDSS J1110+6459 at z = 0.659, with a total magnification ~30x across the entire arc. We use a hybrid parametric/non-parametric strong lensing mass model to compute the deflection and magnification of this giant arc, reconstruct the light distribution of the lensed galaxy in the source plane, and resolve the star formation into two dozen clumps. We develop a forward-modeling technique to model each clump in the source plane. We ray trace the model to the image plane, convolve with the instrumental point spread function (PSF), and compare with the GALFIT model of the clumps in the image plane, which decomposes clump structure from more extended emission. This technique has the advantage, over ray tracing, by accounting for the asymmetric lensing shear of the galaxy in the image plane and the instrument PSF. At this resolution, we can begin to study star formation on a clump-by-clump basis, toward the goal of understanding feedback mechanisms and the buildup of exponential disks at high redshift.Comment: 19 pages, 12 figures, accepted to Ap

Lens Model and Time Delay Predictions for the Sextuply Lensed Quasar SDSS J2222+2745

SDSS J2222+2745 is a galaxy cluster at z=0.49, strongly lensing a quasar at z=2.805 into six widely separated images. In recent HST imaging of the field, we identify additional multiply lensed galaxies, and confirm the sixth quasar image that was identified by Dahle et al. (2013). We used the Gemini North telescope to measure a spectroscopic redshift of z=4.56 of one of the secondary lensed galaxies. These data are used to refine the lens model of SDSS J2222+2745, compute the time delay and magnifications of the lensed quasar images, and reconstruct the source image of the quasar host and a second lensed galaxy at z=2.3. This second galaxy also appears in absorption in our Gemini spectra of the lensed quasar, at a projected distance of 34 kpc. Our model is in agreement with the recent time delay measurements of Dahle et al. (2015), who found tAB=47.7+/-6.0 days and tAC=-722+/-24 days. We use the observed time delays to further constrain the model, and find that the model-predicted time delays of the three faint images of the quasar are tAD=502+/-68 days, tAE=611+/-75 days, and tAF=415+/-72 days. We have initiated a follow-up campaign to measure these time delays with Gemini North. Finally, we present initial results from an X-ray monitoring program with Swift, indicating the presence of hard X-ray emission from the lensed quasar, as well as extended X-ray emission from the cluster itself, which is consistent with the lensing mass measurement and the cluster velocity dispersion.Comment: 16 pages, 11 figures; submitted to Ap

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turn-over by the ubiquitin-proteasome pathway is regulated through phosphorylation of Myc Box I and ubiquitination by SCFFbxw7. However, N-Myc protein is stabilized in neuroblastoma by Aurora-A kinase in a manner that is sensitive to certain Aurora-A-selective inhibitors. Here we identify a direct interaction between the catalytic domain of Aurora-A and a site flanking Myc Box I that also binds SCFFbxw7. We determine the crystal structure of the complex between Aurora-A and this region of N-Myc to 1.72 Å resolution. The structure indicates that the conformation of Aurora-A induced by compounds such as alisertib and CD532 is not compatible with binding of N-Myc, explaining the activity of these compounds in neuroblastoma cells and providing a rational basis for the design of cancer therapeutics optimized for destabilization of the complex. We also propose a model for the stabilization mechanism in which binding to Aurora-A alters how N-Myc interacts with SCFFbxw7 to disfavor the generation of Lys48-linked poly-Ub chains