Medida de fuerzas en túnel aerodinámico sobre perfiles fabricados mediante impresora 3D

El objeto del Trabajo Final de Grado es, tras la comprobación de que el traslado de localización del túnel aerodinámico no ha afectado en las prestaciones del mismo, el estudio de perfiles aerodinámicos fabricados con tecnología de impresión 3D. Estudio llevado a cabo mediante la medida de las fuerzas de sustentación y arrastre en los mismos utilizando una balanza aerodinámica previamente calibrada. -Comprobar el correcto funcionamiento tras el traslado. Tras el traslado del túnel aerodinámico este ha podido sufrir daños. Para evaluarlos se medirá el perfil de velocidades medias, mediante Pitot, en distintas secciones de la zona de ensayos del túnel. Se medirá, manteniendo un régimen de giro del ventilador constante, transversal y longitudinalmente en distintos puntos de cada sección. -Puesta a punto de la balanza aerodinámica. Para lo que se realizará su calibración, tanto para la medida del arrastre como para la sustentación con un montaje de perfiles de estantería y roldanas. Además se llevarán a cabo medidas en perfiles aerodinámicos NACA 0012 de ambas fuerzas para diferentes ángulos de ataque y números de Reynolds, con objeto de verificar sus diferencias y contrastarlas con datos de referencia. · Perfiles aerodinámicos. Los fabricamos con impresoras 3D con la intención de comprobar la calidad de los modelos obtenidos con esta tecnología. Utilizaremos distintas impresoras y procesos de fabricación para evaluar cuál es el más adecuado. Además realizaremos medidas de rugosidad sobre los mismos y evaluaremos la importancia de este parámetro sobre los coeficientes adimensionales de los perfiles.Escuela Técnica Superior de Ingeniería IndustrialUniversidad Politécnica de Cartagen

Total and high molecular weight adiponectin have similar utility for the identification of insulin resistance

<p>Abstract</p> <p>Background</p> <p>Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better marker of IR than total adiponectin. The objective of this study is to compare the utility of total adiponectin, HMWA and the HMWA/total adiponectin index (S_Aindex) for the identification of IR and related metabolic conditions.</p> <p>Methods</p> <p>A cross-sectional analysis was performed in a group of ambulatory subjects, aged 20 to 70 years, in Mexico City. Areas under the receiver operator characteristic (ROC) curve for total, HMWA and the S_Aindex were plotted for the identification of metabolic disturbances. Sensitivity and specificity, positive and negative predictive values, and accuracy for the identification of IR were calculated.</p> <p>Results</p> <p>The study included 101 men and 168 women. The areas under the ROC curve for total and HMWA for the identification of IR (0.664 <it>vs</it>. 0.669, <it>P </it>= 0.74), obesity (0.592 <it>vs</it>. 0.610, <it>P </it>= 0.32), hypertriglyceridemia (0.661 <it>vs</it>. 0.671, <it>P </it>= 0.50) and hypoalphalipoproteinemia (0.624 <it>vs</it>. 0.633, <it>P </it>= 0.58) were similar. A total adiponectin level of 8.03 μg/ml was associated with a sensitivity of 57.6%, a specificity of 65.9%, a positive predictive value of 50.0%, a negative predictive value of 72.4%, and an accuracy of 62.7% for the diagnosis of IR. The corresponding figures for a HMWA value of 4.25 μg/dl were 59.6%, 67.1%, 51.8%, 73.7% and 64.2%.</p> <p>The area under the ROC curve of the S_Aindex for the identification of IR was 0.622 [95% CI 0.554-0.691], obesity 0.613 [95% CI 0.536-0.689], hypertriglyceridemia 0.616 [95% CI 0.549-0.683], and hypoalphalipoproteinemia 0.606 [95% CI 0.535-0.677].</p> <p>Conclusions</p> <p>Total adiponectin, HMWA and the S_Aindex had similar utility for the identification of IR and metabolic disturbances.</p

Importance of Preserved Tricuspid Valve Function for Effective Soft Robotic Augmentation of the Right Ventricle in Cases of Elevated Pulmonary Artery Pressure

Purpose: In clinical practice, many patients with right heart failure (RHF) have elevated pulmonary artery pressures and increased afterload on the right ventricle (RV). In this study, we evaluated the feasibility of RV augmentation using a soft robotic right ventricular assist device (SRVAD), in cases of increased RV afterload. Methods: In nine Yorkshire swine of 65-80 kg, a pulmonary artery band was placed to cause RHF and maintained in place to simulate an ongoing elevated afterload on the RV. The SRVAD was actuated in synchrony with the ventricle to augment native RV output for up to one hour. Hemodynamic parameters during SRVAD actuation were compared to baseline and RHF levels. Results: Median RV cardiac index (CI) was 1.43 (IQR, 1.37-1.80) L/min/m(2) and 1.26 (IQR 1.05-1.57) L/min/m(2) at first and second baseline. Upon PA banding RV CI fell to a median of 0.79 (IQR 0.63-1.04) L/min/m(2). Device actuation improved RV CI to a median of 0.87 (IQR 0.78-1.01), 0.85 (IQR 0.64-1.59) and 1.11 (IQR 0.67-1.48) L/min/m(2) at 5 min (p = 0.114), 30 min (p = 0.013) and 60 (p = 0.033) minutes respectively. Statistical GEE analysis showed that lower grade of tricuspid regurgitation at time of RHF (p = 0.046), a lower diastolic pressure at RHF (p = 0.019) and lower mean arterial pressure at RHF (p = 0.024) were significantly associated with higher SRVAD effectiveness. Conclusions: Short-term augmentation of RV function using SRVAD is feasible even in cases of elevated RV afterload. Moderate or severe tricuspid regurgitation were associated with reduced device effectiveness

Factors associated with postprandial lipemia and apolipoprotein A-V levels in individuals with familial combined hyperlipidemia

Peer reviewe

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. Video Abstract [Figure presented] Keywords: type 2 diabetes (T2D); genetics; disease mechanism; SLC16A11; MCT11; solute carrier (SLC); monocarboxylates; fatty acid metabolism; lipid metabolism; precision medicin

Analisis de la Parroquia del Santo Niño de la Paz

Tesis (Licenciado en Ingeniero Arquitecto), Instituto Politécnico Nacional, Licenciatura, ESIA, Unidad Tecamachalco, 2018, 1 archivo PDF, (103 páginas). tesis.ipn.m

Antocianinas y color en grano y olote de maíz morado peruano cultivado en Jalisco, México

El grano y olote de maíz (Zea maysL.) de color morado son fuente de pigmentos, quepueden sustituir a los colorantes artificiales. El objetivo fuedeterminar el efecto del ambiente(temperatura)de producciónde semilla en el contenido de antocianinas en grano (CATg) y olote (CATo) y su correlación en una población de maíz morado de Perú. Los ambientes de producción de semilla fueron Tepatitlán y La Huerta, Jalisco, México. Las semillas de los dos ambientes sesembraronen el ciclo PV2015 en Tepatitlán, Jalisco. Se polinizaron de 100 a 130 plantas. A la cosecha, las mazorcas sanas y con el color de grano morado intenso, fueron analizadas por CATg y CATomediante espectrofotometría.Se hizo un análisis de varianza y correlación de Person. El ambiente de producciónde semilla afectó de manera significativa (p≤0.05) los contenidos de antocianinas en grano y olote. Lasemilla obtenida enTepatitlán (temperatura. media 19.1°C) presentó un CATgde 496.3 mg equivalentes de cianidina 3-glucósido en 100 g de muestra seca, que fue 57.6% superior al de la semilla procedente deLa Huerta (temp. media 25.4°C). El olote presentó entre 48 y 70% más antocianinas que el grano y perfil cromatográfico similar entre grano y olote. La correlación entre las variables de color de grano y el CATg no fue significativa (p≥0.05). Pero, la correlación negativa del valor de croma con CATofue altamente significativa (r=-0.5484**) por lo que podría ser estimador del CAT en esta estructura.The grain and cob (Zea maysL.) of purple corn are a source of pigments, which can replace artificial colors. The objective was to determine the effect of the environment (temperature) of seed production on the content of anthocyanins in grain (CATg) and cob(CATo) and its correlation in a purple corn population of Peru. Seed production environments were Tepatitlan and La Huerta, Jalisco, Mexico. The seeds of the two environments were sown in the S-S2015 cycle in Tepatitlan, Jalisco. They were pollinated from 100 to 130 plants. At harvest, the healthy ears with the intense purple grain color were analyzed by CATg and CATo by spectrophotometry. An analysis of variance and correlation of Person was made. The environment of seed production significantly affected (p≤ 0.05) the contents of anthocyanins in grain and cob. The seed obtained in Tepatitlan (average temperature 19.1 °C) presenteda CATg of 496.3 mg equivalents of cyanidin 3-glucoside in 100 g of dry sample, which was 57.6% higher than that of the seed from La Huerta (mean temperature 25.4 °C). The cobpresented between 48 and 70% more anthocyanins than the grain and similar chromatographic profile between grain and cob. The correlation between the grain color variables and the CATg was not significant (p≥ 0.05). However, the negative correlation of the chroma value with CATo was highly significant (r= -0.5484**) so it could be an estimator of the CAT in this structur