Les défis du passeport biologique: du prélèvement à l’interprétation

L’Agence Mondiale Antidopage a officiellement lancé le passeport biologique en 2008. Le premier module validé pour lutter contre l’érythropoïétine (EPO) et la transfusion sanguine fut le module sanguin. Il a été très efficace pour attraper des athlètes dopés, et il a particulièrement réduit la prévalence du dopage sanguin. On ne sait pas si les athlètes ont arrêté le dopage ou se sont adaptés et prennent des micros doses d’EPO ou se transfusent de petits volumes de sang. Plus récemment, le module stéroïdien a été mis en place, mais jusqu’à présent, le nombre de cas de passeports urinaires atypiques a été très faible. L’une des raisons évoquées semble être le manque de standardisation des conditions pré-analytiques et analytiques. Ceci a pour effet d’accroître considérablement la variabilité intra-individuelle et diminuer significativement la sensibilité du modèle adaptatif. Des ressources doivent être investies pour améliorer le système actuel et empêcher ainsi les athlètes d’abuser de la testostérone et des composés apparentés

The embedded clusters DBS 77, 78, 102, and 160-161 and their link with the interstellar medium

Aims. We report a study of the global properties of some embedded clusters placed in the fourth quadrant of the Milky Way to clarify some issues related with their location into the Galaxy and their stellar formation processes. Methods. We performed BVI photometric observations in the region of DBS 77, 78, 102, 160, and 161 clusters and infrared spectroscopy in DBS 77 region. They were complemented with JHK data from VVV survey combined with 2MASS catalogue, and used mid-infrared information from GLIMPSE catalogue. We also searched for HI data from SGPS and PMN radio surveys, and previous spectroscopic stellar classification. The spectroscopic and photometric information allowed us to estimate the spectral classification of the brightest stars of each studied region. On the other hand, we used the radio data to investigate the interstellar material parameters and the continuum sources probably associated with the respective stellar components. Results. We estimated the basic physical parameters of the clusters (reddening, distance, age, and initial mass function). We searched for HII regions located near to the studied clusters and we analyzed the possible link between them. In the particular case of DBS 160-161 clusters, we identified the HI bubble B332.5-0.1-42 located around them. We found that the mechanical energy injected to the interstellar medium by the more massive stars of this couple of clusters was enough to generate the bubble.Comment: 15 pages, 14 figures, 6 tables, accepted for publication in A&

Basic parameters of three star clusters in the Small Magellanic Cloud: Kron 11, Kron 63 and NGC 121

We present observations for three star clusters, Kron 11, Kron 63 and NGC 121, in the Small Magellanic Cloud. We have studied their structure and derived their fundamental parameters by means of their luminosity functions, their colour magnitude diagrams and the Padova suite of isochrones. NGC 121 is a well-studied object, for which we confirm previous evidence about its old age and low-metal content, and have found that it is an undergoing mass segregation. Kron 11 and Kron 63 are poorly populated clusters which had never been studied so far. Kron 11 is several gigayears younger than NGC 121, while Kron 63 is basically a very young star aggregate. Both clusters are immersed in dense stellar fields which share the same population properties, suggesting that in their cases, cluster ages are consistent with typical ages of field stars.Instituto de Astrofísica de La PlataFacultad de Ciencias Astronómicas y Geofísica

Basic parameters of three star clusters in the Small Magellanic Cloud: Kron 11, Kron 63 and NGC 121

We present observations for three star clusters, Kron 11, Kron 63 and NGC 121, in the Small Magellanic Cloud. We have studied their structure and derived their fundamental parameters by means of their luminosity functions, their colour magnitude diagrams and the Padova suite of isochrones. NGC 121 is a well-studied object, for which we confirm previous evidence about its old age and low-metal content, and have found that it is an undergoing mass segregation. Kron 11 and Kron 63 are poorly populated clusters which had never been studied so far. Kron 11 is several gigayears younger than NGC 121, while Kron 63 is basically a very young star aggregate. Both clusters are immersed in dense stellar fields which share the same population properties, suggesting that in their cases, cluster ages are consistent with typical ages of field stars.Instituto de Astrofísica de La PlataFacultad de Ciencias Astronómicas y Geofísica

Antidoping programme and biological monitoring before and during the 2014 FIFA World Cup Brazil.

BACKGROUND: The FIFA has implemented an important antidoping programme for the 2014 FIFA World Cup. AIM: To perform the analyses before and during the World Cup with biological monitoring of blood and urine samples. METHODS: All qualified players from the 32 teams participating in the World Cup were tested out-of-competition. During the World Cup, 2-8 players per match were tested. Over 1000 samples were collected in total and analysed in the WADA accredited Laboratory of Lausanne. RESULTS: The quality of the analyses was at the required level as described in the WADA technical documents. The urinary steroid profiles of the players were stable and consistent with previously published papers on football players. During the competition, amphetamine was detected in a sample collected on a player who had a therapeutic use exemption for attention deficit hyperactivity disorder. The blood passport data showed no significant difference in haemoglobin values between out-of-competition and postmatch samples. CONCLUSIONS: Logistical issues linked to biological samples collection, and the overseas shipment during the World Cup did not impair the quality of the analyses, especially when used as the biological passport of football players

The UEFA EURO 2012 anti-doping programme - scientific review

The final tournament of the UEFA European Football Championship is one of the top sporting events in the world, and a high-profile event of this kind requires a well-planned and well-executed anti-doping programme to ensure the integrity of results in the competition. UEFA EURO 2012 presented a unique logistical challenge, with the tournament spread across two countries, both covering a large geographical area. This paper discusses the planning and delivery of both the pre tournament out-of-competition (OOC) testing programme and the in-competition (IC) programme, as well as reviewing the activities of doping control officers (DCOs), the whereabouts programme and assessing the sample collection and transport process. The analytical approach applied is also discussed, along with an overview of the distribution of T/E ratios and blood parameters

Mosquito nets in a rural area of Western Kenya: ownership, use and quality

<p>Abstract</p> <p>Background</p> <p>Insecticide-treated nets (ITNs) are regarded as one of the most effective strategies to prevent malaria in Africa. This study analyses the use and quality of nets owned by households in an area of high net coverage.</p> <p>Methods</p> <p>A structured questionnaire on ownership and use of nets was administered to the households of individuals sampled from a local health centre in south Kisii district, Kenya. A physical inspection of all the nets in the households was done and their conditions recorded on spot check forms designed for that purpose.</p> <p>Results</p> <p>Of the 670 households surveyed, 95% owned at least one net. Only 59% of household residents slept under a net during the night prior to the survey. 77% of those who slept under a net used an insecticide-treated net (ITN) or long-lasting insecticide-treated nets (LLIN). Out of 1,627 nets in the survey households, 40% were deemed to be of poor quality because of holes. Compared to other age groups, children aged 5-14 years were most likely to have slept under nets of poor quality (odds ratio 1.41; <it>p </it>= 0.007).</p> <p>Conclusions</p> <p>Although net ownership was high following increased delivery of ITNs, continuous promotion of effective maintenance and routine use is needed and efforts to replace damaged nets must be implemented.</p

Massive open star clusters using the VVV survey, I: presentation of the data and description of the approach

Context. The ESO Public Survey “VISTA Variables in the Vía Láctea” (VVV) provides deep multi-epoch infrared observations for unprecedented 562 sq. degrees of the Galactic bulge, and adjacent regions of the disk. Aims. The VVV observations will foster the construction of a sample of Galactic star clusters with reliable and homogeneously derived physical parameters (e.g., age, distance, and mass, etc.). In this first paper in a series, the methodology employed to establish cluster parameters for the envisioned database are elaborated upon by analysing four known young open clusters: Danks 1, Danks 2, RCW 79, and DBS 132. The analysis offers a first glimpse of the information that can be gleaned from the VVV observations for clusters in the final database. Methods. Wide-field, deep JHKs VVV observations, combined with new infrared spectroscopy, are employed to constrain fundamental parameters for a subset of clusters. Results. Results are inferred from VVV near-infrared photometry and numerous low resolution spectra (typically more than 10 per cluster). The high quality of the spectra and the deep wide–field VVV photometry enables us to precisely and independently determine the characteristics of the clusters studied, which we compare to previous determinations. An anomalous reddening law in the direction of the Danks clusters is found, specifically E(J − H)/E(H − Ks) = 2.20 ± 0.06, which exceeds published values for the inner Galaxy. The G305 star forming complex, which includes the Danks clusters, lies beyond the Sagittarius-Carina spiral arm and occupies the Centaurus arm. Finally, the first deep infrared colour-magnitude diagram of RCW 79 is presented, which reveals a sizeable pre-main sequence population. A list of candidate variable stars in G305 region is reported. Conclusions. This study demonstrates the strength of the dataset and methodology employed, and constitutes the first step of a broader study which shall include reliable parameters for a sizeable number of poorly characterised and/or newly discovered clusters.Fil: Chené, A.-N.. Universidad de Valparaíso; ChileFil: Borissova, J.. Universidad de Valparaíso; ChileFil: Clarke, J. R. A.. Universidad de Valparaíso; ChileFil: Bonatto, C.. Universidade Federal do Rio Grande do Sul; BrasilFil: Majaess, D. J.. Saint Marys University; CanadáFil: Moni Bidin, C.. Universidad de Concepción; ChileFil: Sale, S. E.. Universidad de Valparaíso; ChileFil: Mauro, F.. Universidad de Concepción; ChileFil: Kurtev, R.. Universidad de Valparaíso; ChileFil: Baume, Gustavo Luis. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Feinstein Baigorri, Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Ivanov, V. D.. European Southern Observatory; ChileFil: Geisler, Doug. Universidad de Concepción; ChileFil: Catelan, M.. The Milky Way Millennium Nucleus; ChileFil: Minniti, Dante. The Milky Way Millennium Nucleus; ChileFil: Lucas, P.. University Of Hertfordshire; Reino UnidoFil: de Grijs, R.. Peking University; ChinaFil: Kumar, M. S. N.. Centro de Astrofisica da Universidade do Porto; Portuga

Massive open star clusters using the VVV survey II. Discovery of six clusters with Wolf-Rayet stars

Context: The ESO Public Survey "VISTA Variables in the V\'ia L\'actea" (VVV) provides deep multi-epoch infrared observations for an unprecedented 562 sq. degrees of the Galactic bulge, and adjacent regions of the disk. In this survey nearly 150 new open clusters and cluster candidates have been discovered. Aims: This is the second in a series of papers about young, massive open clusters observed using the VVV survey. We present the first study of six recently discovered clusters. These clusters contain at least one newly discovered Wolf-Rayet (WR) star. Methods: Following the methodology presented in the first paper of the series, wide-field, deep JHKs VVV observations, combined with new infrared spectroscopy, are employed to constrain fundamental parameters for a subset of clusters. Results: We affirm that the six studied stellar groups are real young (2-7 Myr) and massive (between 0.8 and 2.2 10^3 Msol) clusters. They are highly obscured (Av ~ 5-24 mag) and compact (1-2 pc). In addition to WR stars, two of the six clusters also contain at least one red supergiant star. We claim the discovery of 8 new WR stars, and 3 stars showing WR-like emission lines which could be classified WR or OIf. Preliminary analysis provides initial masses of ~30-50 Msol for the WR stars. Finally,we discuss the spiral structure of the Galaxy using as tracers the six new clusters together with the previously studied VVV clusters.Comment: 17 pages, 8 figurs, accepted in A&

Worldwide distribution of blood values in elite track and field athletes: Biomarkers of altered erythropoiesis.

For the first time, blood samples were collected in all athletes participating in a major sporting event of the International Association of Athletics Federations (IAAF) (Athletics World Championships 2011, Daegu, Korea). All variables obtained from blood analyses were incorporated into the individual blood profiles of each athlete for the so-called athlete biological passport (ABP). This unprecedented data collection highlighted differences for a few blood biomarkers commonly measured and reported for the ABP on some group of athletes. Subsequently, blood tests analyses for all athletes were repeated during the following World Championships (2013, Moscow, Russia). Both sets of blood tests were then used to set up the distribution of blood values for track and field athletes considering potential confounding factors such as gender, age, discipline, origin of the athlete (continental classification), and time of blood collection. Implementation of well-defined distribution of blood values will allow to improve the estimation of blood doping prevalence among a specific population of athletes in track and field