In democracies an effective media and opposition are both needed to sanction leaders’ foreign policy missteps

Common wisdom in international affairs is that when democratically elected leaders and governments make threats towards other states, these are credible; voters will punish leaders who do not follow through on their words. New research by Philip B. K. Potter and Matthew A. Baum argues however, that not all democracies are equal in the credibility of their threats of military action. By analyzing data on international military disputes over a 35-year period, they find that both an effective and widespread media, and a robust opposition are needed in order for voters to become aware of foreign policy blunders. Without either of these, leaders can avoid following through on their threats with little fear of being punished by voters

6C radio galaxies at z~1: The influence of radio power on the alignment effect

Powerful radio galaxies often display enhanced optical/UV continuum emission and extended emission line regions, elongated and aligned with the radio jet axis. The expansion of the radio source strongly affects the gas clouds in the surrounding IGM, and the kinematic and ionization properties of the extended emission line regions display considerable variation over the lifetime of individual sources, as well as with cosmic epoch. We present the results of deep rest-frame UV and optical imaging and UV spectroscopy of high redshift 6C radio galaxies. The interdependence of the host galaxy and radio source properties are discussed, considering: (i) the relative contribution of shocks associated with the expanding radio source to the observed emission line gas kinematics, and their effect on the ionization state of the gas; (ii) the similarities and differences between the morphologies of the host galaxies and aligned emission for a range of radio source powers; and (iii) the influence of radio power on the strength of the observed alignment effect.Comment: LaTeX, 6 pages, 5 figures, Elsevier Science format. To appear in "Radio galaxies: past, present & future". eds. M. Jarvis et al., Leiden, Nov 200

Acoustic analyses and perceptual data on anticipatory labial coarticulation in adults and children

The present study investigated anticipatory labial coarticulation in the speech of adults and children. CV syllables, [s], [t], and [d] before [i] and [u], were produced by an adult male speaker and a female child speaker age 3 years 6 months. Each syllable was computer‐edited to include only the noise‐excited portion of fricative‐vowel stimuli and only the aperiodic portion of stop‐vowel stimuli. LPC spectra were computed for each excised segment. Analyses of the effect of the following vowel on the spectral peak associated with the second formant frequency and on the characteristic spectral prominence for each consonant were performed. Perceptual data were obtained by presenting the aperiodic consonantal segments to subjects who were instructed to identify in a forced choice paradigm the following vowel [i] or [u]. Both the acoustic and perceptual data show strong coarticulatory effects for adults and the absence of such coarticulations in the speech stimuli of the child. The results are discussed in terms of the articulatory and perceptual aspects of coarticulation in language learning

Acoustic analyses and perceptual data on anticipatory labial coarticulation in adults and children

This is the published version, also available here: http://dx.doi.org/10.1121/1.394917.The present study investigated anticipatory labial coarticulation in the speech of adults and children. CV syllables, composed of [s], [t], and [d] before [i] and [u], were produced by four adult speakers and eight child speakers aged 3–7 years. Each stimulus was computer edited to include only the aperiodic portion of fricative‐vowel and stop‐vowel syllables. LPC spectra were then computed for each excised segment. Analyses of the effect of the following vowel on the spectral peak associated with the second formant frequency and on the characteristic spectral prominence for each consonant were performed. Perceptual data were obtained by presenting the aperiodic consonantal segments to subjects who were instructed to identify the following vowel as [i] or [u]. Both the acoustic and the perceptual data show strong coarticulatory effects for the adults and comparable, although less consistent, coarticulation in the speech stimuli of the children. The results are discussed in terms of the articulatory and perceptual aspects of coarticulation in language learning

Psychometric validation of the revised SCOPA-Diary Card: expanding the measurement of non-motor symptoms in parkinson's disease

<p>Abstract</p> <p>Background</p> <p>To identify key non-motor symptoms of Parkinson's disease (PD) to include in a daily diary assessment for off-time, revise the Scales for Outcomes of Parkinson's disease Diary Card (SCOPA-DC) to include these non-motor symptoms, and investigate the validity, reliability and predictive utility of the Revised SCOPA-DC in a U.S. population.</p> <p>Methods</p> <p>A convenience sample was used to recruit four focus groups of PD patients. Based on findings from focus groups, the SCOPA-DC was revised and administered to a sample of 101 PD patients. Confirmatory factor analysis was conducted to test the domain structure of the Revised SCOPA-DC. The reliability, convergent and discriminant validity, and ability to predict off-time of the Revised SCOPA-DC were then assessed.</p> <p>Results</p> <p>Based on input from PD patients, the Revised SCOPA-DC included several format changes and the addition of non-motor symptoms. The Revised SCOPA-DC was best represented by a three-factor structure: Mobility, Physical Functioning and Psychological Functioning. Correlations between the Revised SCOPA-DC and other Health-Related Quality of Life scores were supportive of convergent validity. Known-groups validity analyses indicated that scores on the Revised SCOPA-DC were lower among patients who reported experiencing off-time when compared to those without off-time. The three subscales had satisfactory predictive utility, correctly predicting off-time slightly over two-thirds of the time.</p> <p>Conclusions</p> <p>These findings provide evidence of content validity of the Revised SCOPA-DC and suggest that a three-factor structure is an appropriate model that provides reliable and valid scores to assess symptom severity among PD patients with symptom fluctuations in the U.S.</p

Activist policy and macroeconomic instability

This paper investigates the consequences of activist monetary policy in a small, aggregate macroeconomic model which embodies traditional hypotheses of price and output determination. It is shown that deterministic control problems with inflation and full employment as objectives may be solved, but multiple-target stochastic control problems will lead to instability in both the targets and the policy instrument.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25350/1/0000797.pd

Trends in age- and sex-specific lung cancer mortality in Europe and Northern America: Analysis of vital registration data from the WHO Mortality Database between 2000 and 2017

Background: In the context of new targeted therapies and immunotherapy as well as screening modalities for lung cancer patients, detailed mortality trends in Europe and Northern America are unknown. Methods: Time-trend analysis using vital registration data of Northern America and Europe from the WHO Mortality Database (years 2000/2017). To assess improvements in lung cancer mortality, we performed a population-averaged Poisson autoregressive analysis. The average annual percent change (AAPC) was used as a summary measure of overall and country-specific trends in mortality. Second, we studied time trends of lung cancer incidence and smoking prevalence rates. Findings: In the total population of 872·5 million people between 2015 and 2017, the average annual age-standardised mortality from lung cancer was 54·6 deaths per 100 000, with substantial differences across countries. Lung cancer was reported as the primary cause of death in 5·4 cases per 100 deaths. The age-standardised mortality rate decreased constantly (AAPC –1·5%) between 2000 and 2017. While mortality in men dropped annually by an average of −2·3%, mortality in women decreased by an average of −0·3%. This slight decline was driven exclusively by the USA. In contrast, 21 out of 31 countries registered a significant increase in female lung cancer mortality between 2000 and 2017, with Spain (AAPC 4·1%) and France (AAPC 3·6%) leading the list. Interpretation: Despite overall decreases in lung cancer mortality trends, female mortality remained unchanged or increased significantly in all countries except the USA. National mortality outcomes reflect variabilities in tobacco control, screening, therapeutic advances, and access to health care

Radio Jets in Galaxies with Actively Accreting Black Holes: new insights from the SDSS

The majority of nearby radio-loud AGN are found in massive, old elliptical galaxies with weak emission lines. At high redshifts,however, most known radio AGN have strong emission lines. In this paper, we examine a subset of radio AGN with emission lines selected from the Sloan Digital Sky Survey. The probability for a nearby radio AGN to have emission lines is a strongly decreasing function of galaxy mass and an increasing function of radio luminosity above 10^25 W/Hz. Emission line and radio luminosities are correlated, but with large dispersion. At a given radio power, AGN with small black holes have higher [OIII] luminosities (which we interpret as higher accretion rates) than AGN with big black holes. However, if we scale both radio and emission line luminosities by the black hole mass, we find a correlation between normalized radio power and accretion rate in Eddington units that is independent of black hole mass. There is also a clear correlation between normalized radio power and the age of the stellar population in the galaxy. Present-day AGN with the highest normalized radio powers are confined to galaxies with small black holes. High-redshift, high radio-luminosity AGN could be explained if big black holes were similarly active at earlier cosmic epochs. To investigate why only a small fraction of emission line AGN become radio loud, we create matched samples of radio-loud and radio-quiet AGN and compare their host galaxy properties and environments. The main difference lies in their environments; our local density estimates are a factor 2 larger around the radio-loud AGN. We propose a scenario in which radio-loud AGN with emission lines are located in galaxies where accretion of both cold and hot gas can occur simultaneously. (Abridged)Comment: 18 figures, submitted to MNRA

Re-engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivo

Because of their easy access, and important role in oral homeostasis, mammalian salivary glands provide a unique site for addressing key issues and problems in tissue engineering. This manuscript reviews studies by us in three major directions involving re-engineering functions of salivary epithelial cells. Using adenoviral-mediated gene transfer in vivo , we show approaches to i) repair damaged, hypofunctional glands and ii) redesign secretory functions to include endocrine as well as exocrine pathways. The third series of studies show our general approach to develop an artificial salivary gland for clinical situations in which all glandular tissue has been lost.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72101/1/j.1749-6632.1999.tb08512.x.pd

Effect of enhanced medical rehabilitation on functional recovery in older adults receiving skilled nursing care after acute rehabilitation: A randomized clinical trial

Importance: Enhanced medical rehabilitation (EMR) is a systematic and standardized approach for physical and occupational therapists to engage patients. Higher patient engagement in therapy might lead to improved functional recovery in rehabilitation settings, such as skilled nursing facilities (SNFs). Objective: To determine whether EMR improves older adults\u27 functional recovery. Design, Setting, and Participants: A double-blind, parallel-group, randomized clinical trial was conducted from July 29, 2014, to July 13, 2018, in 229 adults aged 65 years or older admitted to 2 US SNFs. Participants were randomized to receive EMR (n = 114) vs standard-of-care rehabilitation (n = 115). Intention-to-treat analysis was used. Interventions: The intervention group received their physical and occupational therapy from therapists trained in EMR. Based on models of motivation and behavior change, EMR is a toolkit of techniques to increase patient engagement and therapy intensity. The control group received standard-of-care rehabilitation from physical and occupational therapists not trained in EMR. Main Outcomes and Measures: The primary outcome was change in function in activities of daily living and mobility, as assessed with the Barthel Index, which measures 10 basic activities of daily living or mobility items (scale range, 0-100), from SNF admission to discharge; secondary outcomes were gait speed for 10 m, 6-minute walk test, discharge disposition, rehospitalizations, and self-reported functional status at days 30, 60, and 90. To examine the rehabilitation process, therapists\u27 engagement with patients and patient active time during therapy were measured for a sample of the sessions. Results: Of the 229 participants, 149 (65.1%) were women; 177 (77.3%) were white, and 51 (22.3%) were black; mean (SD) age was 79.3 (8.0) years. Participants assigned to EMR showed greater recovery of function than those assigned to standard of care (mean increase in Barthel Index score, 35 points; 95% CI, 31.6-38.3 vs 28 points; 95% CI, 25.2-31.7 points; P = .007). There was no evidence of a difference in the length of stay (mean [SD], 23.5 [13.1] days). However, there were no group by time differences in secondary outcome measures, including self-reported function after SNF discharge out to 90 days as measured on the Barthel Index (mean [SE] score: EMR, 83.65 [2.20]; standard of care, 84.67 [2.16]; P = .96). The EMR therapists used a median (interquartile range) of 24.4 (21.0-37.3) motivational messages per therapy session vs 2.3 (1.1-2.9) for nontrained therapists (P \u3c .001), and EMR patients were active during a mean (SD) of 52.5 (6.6%) of the therapy session time vs 41.2 (6.8%) for nontrained therapists (P = .001). Conclusions and Relevance: Enhanced medical rehabilitation modestly improved short-term functional recovery for selected older adults rehabilitating in SNFs. However, there was no evidence that the benefits persisted over the longer term. This study demonstrates the value of engaging and motivating older adults in rehabilitation therapy, but more work is needed to extend these benefits to longer-term outcomes after discharge home. Trial Registration: ClinicalTrials.gov identifier: NCT02114879