4,032 research outputs found
Electroweak Gauge-Boson Production at Small q_T: Infrared Safety from the Collinear Anomaly
Using methods from effective field theory, we develop a novel, systematic
framework for the calculation of the cross sections for electroweak gauge-boson
production at small and very small transverse momentum q_T, in which large
logarithms of the scale ratio M_V/q_T are resummed to all orders. These cross
sections receive logarithmically enhanced corrections from two sources: the
running of the hard matching coefficient and the collinear factorization
anomaly. The anomaly leads to the dynamical generation of a non-perturbative
scale q_* ~ M_V e^{-const/\alpha_s(M_V)}, which protects the processes from
receiving large long-distance hadronic contributions. Expanding the cross
sections in either \alpha_s or q_T generates strongly divergent series, which
must be resummed. As a by-product, we obtain an explicit non-perturbative
expression for the intercept of the cross sections at q_T=0, including the
normalization and first-order \alpha_s(q_*) correction. We perform a detailed
numerical comparison of our predictions with the available data on the
transverse-momentum distribution in Z-boson production at the Tevatron and LHC.Comment: 34 pages, 9 figure
Factorization and NNLL Resummation for Higgs Production with a Jet Veto
Using methods of effective field theory, we derive the first all-order
factorization theorem for the Higgs-boson production cross section with a jet
veto, imposed by means of a standard sequential recombination jet algorithm.
Like in the case of small-q_T resummation in Drell-Yan and Higgs production,
the factorization is affected by a collinear anomaly. Our analysis provides the
basis for a systematic resummation of large logarithms log(m_H/p_T^veto) beyond
leading-logarithmic order. Specifically, we present predictions for the
resummed jet-veto cross section and efficiency at next-to-next-to-leading
logarithmic order. Our results have important implications for Higgs-boson
searches at the LHC, where a jet veto is required to suppress background
events.Comment: 28 pages, 5 figures; v2: published version; note added in proo
Thermally driven spin injection from a ferromagnet into a non-magnetic metal
Creating, manipulating and detecting spin polarized carriers are the key
elements of spin based electronics. Most practical devices use a perpendicular
geometry in which the spin currents, describing the transport of spin angular
momentum, are accompanied by charge currents. In recent years, new sources of
pure spin currents, i.e., without charge currents, have been demonstrated and
applied. In this paper, we demonstrate a conceptually new source of pure spin
current driven by the flow of heat across a ferromagnetic/non-magnetic metal
(FM/NM) interface. This spin current is generated because the Seebeck
coefficient, which describes the generation of a voltage as a result of a
temperature gradient, is spin dependent in a ferromagnet. For a detailed study
of this new source of spins, it is measured in a non-local lateral geometry. We
developed a 3D model that describes the heat, charge and spin transport in this
geometry which allows us to quantify this process. We obtain a spin Seebeck
coefficient for Permalloy of -3.8 microvolt/Kelvin demonstrating that thermally
driven spin injection is a feasible alternative for electrical spin injection
in, for example, spin transfer torque experiments
An experimentally-achieved information-driven Brownian motor shows maximum power at the relaxation time
We present an experimental realization of an information-driven Brownian motor by periodically cooling a Brownian particle trapped in a harmonic potential connected to a single heat bath, where cooling is carried out by the information process consisting of measurement and feedback control. We show that the random motion of the particle is rectified by symmetry-broken feedback cooling where the particle is cooled only when it resides on the specific side of the potential center at the instant of measurement. Studying how the motor thermodynamics depends on cycle period tau relative to the relaxation time tau(B) of the Brownian particle, we find that the ratcheting of thermal noise produces the maximum work extraction when tau >= 5 tau(B) while the extracted power is maximum near tau= tau(B), implying the optimal operating time for the ratcheting process. In addition, we find that the average transport velocity is monotonically decreased as tau increases and present the upper bound for the velocity
Bottom mixed layer oxygen dynamics in the Celtic Sea
The seasonally stratified continental shelf seas are highly productive, economically important environments which are under considerable pressure from human activity. Global dissolved oxygen concentrations have shown rapid reductions in response to anthropogenic forcing since at least the middle of the twentieth century. Oxygen consumption is at the same time linked to the cycling of atmospheric carbon, with oxygen being a proxy for carbon remineralisation and the release of CO2. In the seasonally stratified seas the bottom mixed layer (BML) is partially isolated from the atmosphere and is thus controlled by interplay between oxygen consumption processes, vertical and horizontal advection. Oxygen consumption rates can be both spatially and temporally dynamic, but these dynamics are often missed with incubation based techniques. Here we adopt a Bayesian approach to determining total BML oxygen consumption rates from a high resolution oxygen time-series. This incorporates both our knowledge and our uncertainty of the various processes which control the oxygen inventory. Total BML rates integrate both processes in the water column and at the sediment interface. These observations span the stratified period of the Celtic Sea and across both sandy and muddy sediment types. We show how horizontal advection, tidal forcing and vertical mixing together control the bottom mixed layer oxygen concentrations at various times over the stratified period. Our muddy-sand site shows cyclic spring-neap mediated changes in oxygen consumption driven by the frequent resuspension or ventilation of the seabed. We see evidence for prolonged periods of increased vertical mixing which provide the ventilation necessary to support the high rates of consumption observed
Top quark forward-backward asymmetry in R-parity violating supersymmetry
The interaction of bottom squark-mediated top quark pair production,
occurring in the R-parity violating minimal supersymmetric standard model
(MSSM), is proposed as an explanation of the anomalously large
forward-backward asymmetry (FBA) observed at the Tevatron. We find that this
model can give a good fit to top quark data, both the inclusive and invariant
mass-dependent asymmetries, while remaining consistent (at the 2-
level) with the total and differential production cross-sections. The scenario
is challenged by strong constraints from atomic parity violation (APV), but we
point out an extra diagram for the effective down quark-Z vertex, involving the
same coupling constant as required for the FBA, which tends to weaken the APV
constraint, and which can nullify it for reasonable values of the top squark
masses and mixing angle. Large contributions to flavor-changing neutral
currents can be avoided if only the third generation of sparticles is light.Comment: 24 pages, 7 figures. v3: included LHC top production cross section
data; model still consistent at 2 sigma leve
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an <i>in vitro</i> model of CNS tuberculosis
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium tuberculosis (Mtb) causes breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture model of the BBB. This increases permeability, surface expression of endothelial adhesion molecules and leukocyte transmigration. TJP breakdown was driven by Mtb-dependent secretion of matrix metalloproteinase (MMP)-9. TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1. In our model, the hedgehog pathway was downregulated by Mtb-stimulation, but Shh levels in astrocytes were unchanged. However, Scube2, a glycoprotein regulating astrocyte Shh release was decreased, inhibiting Shh delivery to brain endothelial cells. Activation of the hedgehog pathway by addition of a Smoothened agonist or by addition of exogenous Shh, or neutralizing MMP-9 activity, decreased permeability and increased TJP expression in the Mtb-stimulated BBB co-cultures. In summary, the BBB is disrupted by downregulation of the Shh pathway and breakdown of TJPs, secondary to increased MMP-9 activity which suggests that these pathways are potential novel targets for host directed therapy in CNS TB
Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial
Background
Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointments for residual memory problems following discharge.
Methods/Design
This is a multi-centre, randomised controlled trial investigating the clinical and cost-effectiveness of a group-based memory rehabilitation programme. Three hundred and twelve people with a traumatic brain injury will be randomised from four centres. Participants will be eligible if they had a traumatic brain injury more than 3 months prior to recruitment, have memory problems, are 18 to 69 years of age, are able to travel to one of our centres and attend group sessions, and are able to give informed consent. Participants will be randomised in clusters of 4 to 6 to the group rehabilitation intervention or to usual care. Intervention groups will receive 10 weekly sessions of a manualised memory rehabilitation programme, which has been developed in previous pilot studies. The intervention will include restitution strategies to retrain impaired memory functions and compensation strategies to enable participants to cope with their memory problems. All participants will receive a follow-up postal questionnaire and an assessment by a research assistant at 6 and 12 months post-randomisation. The primary outcome is the Everyday Memory Questionnaire at 6 months. Secondary outcomes include the Rivermead Behavioural Memory Test-3, General Health Questionnaire-30, health related quality of life, cost-effectiveness analysis determined by the EQ-5D and a service use questionnaire, individual goal attainment, European Brain Injury Questionnaire (patient and relative versions), and the Everyday Memory Questionnaire-relative version. The primary analysis will be based on intention to treat. A mixed-model regression analysis of the Everyday Memory Questionnaire at 6 months will be used to estimate the effect of the group memory rehabilitation programme.
Discussion
The study will hopefully provide robust evidence regarding the clinical and cost-effectiveness of a group-based memory rehabilitation intervention for civilians and military personnel following TBI. We discuss our decision-making regarding choice of outcome measures and control group, and the unique challenges to recruiting people with memory problems to trials
Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (delta psi m). Here, we show that PorB induces the condensation of the mitochondrial matrix and the loss of cristae structures, sensitizing cells to the induction of apoptosis via signaling pathways activated by BH3-only proteins. PorB is imported into mitochondria through the general translocase TOM but, unexpectedly, is not recognized by the SAM sorting machinery, usually required for the assembly of beta-barrel proteins in the mitochondrial outer membrane. PorB integrates into the mitochondrial inner membrane, leading to the breakdown of delta psi m. The PorB channel is regulated by nucleotides and an isogenic PorB mutant defective in ATP-binding failed to induce delta psi m loss and apoptosis, demonstrating that dissipation of delta psi m is a requirement for cell death caused by neisserial infection
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