Using directional curvatures to visualize folding patterns of the GTM projection manifolds

In data visualization, characterizing local geometric properties of non-linear projection manifolds provides the user with valuable additional information that can influence further steps in the data analysis. We take advantage of the smooth character of GTM projection manifold and analytically calculate its local directional curvatures. Curvature plots are useful for detecting regions where geometry is distorted, for changing the amount of regularization in non-linear projection manifolds, and for choosing regions of interest when constructing detailed lower-level visualization plots

Reliabilität der statischen Posturografie bei älteren Personen

Zusammenfassung: Hintergrund und Zielsetzung: Die statische Posturografie ist eine Messmethode für die Bewegungen des Körperdruckpunktes. Mit ihr werden beispielsweise ältere sturzgefährdete Patienten untersucht. Ob die statische Posturografie ein reliables Messinstrument bei älteren Menschen ist, konnte bisher nicht endgültig geklärt werden. Mit der vorliegenden Arbeit sollte die intraindividuelle Reliabilität der statischen Posturografie bei älteren Senioren geprüft werden. Probanden und Methode: Die intraindividuelle Reliabilität von 11Messparametern der statischen Posturografie wurde bei 30 älteren Senioren untersucht. Messparameter waren: die Durchschnittsgeschwindigkeit der Druckpunktbewegung in mm/s, die Länge der Druckpunktbewegung in mm, die Schwankungsfläche in mm2, die Amplituden der Druckpunktbewegung, die Oszillationsachse in Grad und die Neigungswinkel der Patienten in Grad. Die drei Messungen fanden am selben Tag im Abstand von zwei Minuten statt. Sie wurden in vier verschiedenen Testpositionen durchgeführt: normaler Stand und Nahstand, jeweils mit offenen und geschlossenen Augen. Die statistische Analyse erfolgte mit Intra-Klassen-Korrelationskoeffizienten. Ergebnisse: Sechs der getesteten Parameter sind sehr gut reliabel, mit einem Korrelationskoeffizienten von jeweils >0,9. Diese sechs Parameter sind: die Durchschnittsgeschwindigkeit der Bewegung des Körperdruckpunktes in mm/s im Nahstand, die Schwankungsfläche in mm2 (im Nahstand mit geschlossenen Augen), die Länge der Druckpunktbewegung in mm (gesamt und in beiden Ebenen) im Normalstand und im Nahstand sowie der Neigungswinkel des Patienten in Grad in der Sagittalebene, im Normalstand und im Nahstand. Von den vier Testpositionen ist die Position "Nahstand mit geschlossenen Augen" am besten geeignet, um reliable Werte zu erhalten. Schlussfolgerung: Sechs der getesteten Parameter können zur Verwendung in Folgestudien empfohlen werden. Als Testposition eignet sich die Position "Nahstand mit geschlossenen Augen". Das vorhandene Messprotokoll liefert reliable Messergebnisse. Ob die verwendeten Parameter zur Diagnostik von Gang- und Balancestörungen geeignet sind, muss in einer Folgestudie geklärt werde

Low-mass dileptons and dropping rho meson mass

Using the transport model, we have studied dilepton production from heavy-ion collisions at Bevalac energies. It is found that the enhanced production of low-mass dileptons observed in the experiment by the DLS collaboration cannot be explained by the dropping of hadron masses, in particular the $\rho$-meson mass, in dense matter.Comment: 9 pages, LaTeX, including 1 postscript figure, to appear in Phys. Lett.

Characteristics of fecal microbiota transplantation use in inflammatory bowel disease cohort

Background: There is a growing interest in the role of gut bacteria in a number of diseases and an emerging hypothesis that inflammatory bowel disease (IBD) is triggered by microbial dysbiosis in genetically susceptible individuals. Currently, fecal microbiota transplantation (FMT) is utilized for the treatment of Clostridium difficile colitis. Data on the efficacy of FMT for IBD are mixed, but patients are interested in its use for the treatment of IBD. We sought to describe the use of FMT (self or medical professional administered) in individuals with IBD using IBD Partners, an Internet-based cohort. Methods: Patients enrolled in the IBD Partners cohort were offered the opportunity to complete an optional survey on the use of FMT between January 2017 to September 2018 (n = 5430). A cross-sectional analysis was performed within patients who completed the survey and did not have a pouch or ostomy. Patients' demographic characteristics, disease activity and phenotype, mode of FMT delivery, and patient-reported efficacy were compared. Results: Among 3274 eligible patients, 51 (1.6%) responded that they had an FMT in the past. Of patients undergoing FMT, 22 patients had the FMT for C. difficile while 29 reported that the FMT was for another indication. Most patients receiving FMT for an indication other than C. difficile had ulcerative colitis/indeterminate colitis (25, 86.2%). Colonoscopy (68.2%) and nasogastric tube (18.2%) were the most common routes of administration for patients receiving FMT for C. difficile colitis. Self-administration (72.4%) and enemas (17.2%) were the most common routes of administration in patients receiving FMT for an alternate indication. Patients reporting FMT for an indication other than C. difficile were less likely to have a physician directing their FMT treatment (20.6%) as compared to patients receiving FMT for C. difficile (86.3%). Patient-reported efficacy was lower for FMT given for a non-C. difficile indication. Conclusions: Patients undergoing FMT for an indication other than C. difficile infection were more likely to have ulcerative colitis, self-administer FMT, and were less likely to be receiving FMT under the guidance of a medical professional. FMT was not as effective for symptoms when given for a non-C. difficile indication. Patients should be counseled on potential harms and lack of proven benefit associated with FMT for IBD indications to try to discourage self-administered FMT without proper medical oversite

Enhancement of low-mass dileptons in heavy-ion collisions

Using a relativistic transport model for the expansion stage of S+Au collisions at 200 GeV/nucleon, we show that the recently observed enhancement of low-mass dileptons by the CERES collaboration can be explained by the decrease of vector meson masses in hot and dense hadronic matter.Comment: 12 pages, RevTeX, 3 figures available from [email protected]

Asymmetry of high-velocity lower crust on the South Atlantic rifted margins and implications for the interplay of magmatism and tectonics in continental breakup

High-velocity lower crust (HVLC) and seaward-dipping reflector (SDR) sequences are typical features of volcanic rifted margins. However, the nature and origin of HVLC is under discussion. Here we provide a comprehensive analysis of deep crustal structures in the southern segment of the South Atlantic and an assessment of HVLC along the margins. Two new seismic refraction lines off South America fill a gap in the data coverage and together with five existing velocity models allow for a detailed investigation of the lower crustal properties on both margins. An important finding is the major asymmetry in volumes of HVLC on the conjugate margins. The seismic refraction lines across the South African margin reveal cross-sectional areas of HVLC 4 times larger than at the South American margin, a finding that is opposite to the asymmetric distribution of the flood basalts in the Paraná–Etendeka Large Igneous Province. Also, the position of the HVLC with respect to the SDR sequences varies consistently along both margins. Close to the Falkland–Agulhas Fracture Zone in the south, a small body of HVLC is not accompanied by SDRs. In the central portion of both margins, the HVLC is below the inner SDR wedges while in the northern area, closer to the Rio Grande Rise-Walvis Ridge, large volumes of HVLC extend far seaward of the inner SDRs. This challenges the concept of a simple extrusive/intrusive relationship between SDR sequences and HVLC, and it provides evidence for formation of the HVLC at different times during the rifting and breakup process. We suggest that the drastically different HVLC volumes are caused by asymmetric rifting in a simple-shear-dominated extension

Efficacy of six months neuromuscular exercise on lumbar movement variability : a randomized controlled trial

Introduction: Lumbar movement variability during heavy, repetitive work may be a protective mechanism to diminish the progression of lumbar disorders and maintain neuromuscular functional integrity. The effect of neuromuscular exercise (NME) on the variability of lumbar movement is still to be determined. Methods: A randomised controlled trial was conducted on a population of nursing personnel with subacute LBP. Following randomization, the NME group participants completed an NME program of six months duration. The participants in the control group only attended the assessment sessions. The outcomes were assessed at: baseline; after six months intervention; 12 months. The primary outcome was lumbar movement variability based on angular displacement and velocity. Results: A positive treatment effect on lumbar movement variability was seen after six months of NME intervention. Angular displacement improved, and angular velocity remained constant. At the 12-month follow up, however, the effect faded in the NME group. Lumbar movement variability worsened in the control group over all time periods. Conclusion: NME may improve lumbar movement variability in the short term and may indicate improved neuromuscular functional integrity. The design of an optimal NME program to achieve long-term improvement in lumbar movement variability is a subject worthy of further research

Black and White Patients with Inflammatory Bowel Disease Show Similar Biologic Use Patterns with Medicaid Insurance

Background: Prior studies have identified racial disparities in the treatment and outcomes of inflammatory bowel disease (IBD). These disparities could be secondary to differences in biology, care delivery, or access to appropriate therapy. The primary aim of this study was to compare medication use among Medicaid-insured black and white patients with IBD, given uniform access to gastroenterologists and therapies. Methods: We analyzed Medicaid Analytic eXtract data from 4 states (California, Georgia, North Carolina, and Texas) between 2006 and 2011. We compared the use of IBD-specific therapies, including analyses of postoperative therapy among patients with Crohn disease (CD). We performed bivariate analyses and multivariable logistic regression, adjusting for potential confounders. Results: We identified 14,735 patients with IBD (4672 black [32%], 8277 with CD [58%]). In multivariable analysis, there was no significant difference in the odds of anti-tumor necrosis factor use by race for CD (adjusted odds ratio [aOR] = 1.13; 95% confidence interval [CI], 0.99-1.28] or ulcerative colitis (aOR = 1.12; 95% CI, 0.96-1.32). Black patients with CD were more likely than white patients to receive combination therapy (aOR = 1.50; 95% CI, 1.15-1.96), and black patients were more likely than white patients to receive immunomodulator monotherapy after surgery for CD (31% vs 18%; P = 0.004). Conclusions: In patients with Medicaid insurance, where access to IBD-specific therapy should be similar for all individuals, there was no significant disparity by race in the utilization of IBD-specific therapies. Disparities in IBD treatment discussed in prior literature seem to be driven by socioeconomic or other issues affecting access to care