17,867 research outputs found
Longtime behavior of nonlocal Cahn-Hilliard equations
Here we consider the nonlocal Cahn-Hilliard equation with constant mobility
in a bounded domain. We prove that the associated dynamical system has an
exponential attractor, provided that the potential is regular. In order to do
that a crucial step is showing the eventual boundedness of the order parameter
uniformly with respect to the initial datum. This is obtained through an
Alikakos-Moser type argument. We establish a similar result for the viscous
nonlocal Cahn-Hilliard equation with singular (e.g., logarithmic) potential. In
this case the validity of the so-called separation property is crucial. We also
discuss the convergence of a solution to a single stationary state. The
separation property in the nonviscous case is known to hold when the mobility
degenerates at the pure phases in a proper way and the potential is of
logarithmic type. Thus, the existence of an exponential attractor can be proven
in this case as well
Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme
The renal endothelium has been debated as arising from resident hemangioblast precursors that transdifferentiate from the nephrogenic mesenchyme (vasculogenesis) and/or from invading vessels (angiogenesis). While the Foxd1-positive renal cortical stroma has been shown to differentiate into cells that support the vasculature in the kidney (including vascular smooth muscle and pericytes) it has not been considered as a source of endothelial cell progenitors. In addition, it is unclear if Foxd1-positive mesenchymal cells in other organs such as the lung have the potential to form endothelium. This study examines the potential for Foxd1-positive cells of the kidney and lung to give rise to endothelial progenitors. We utilized immunofluorescence (IF) and fluorescence-activated cell sorting (FACS) to co-label Foxd1-expressing cells (including permanently lineage-tagged cells) with endothelial markers in embryonic and postnatal mice. We also cultured FACsorted Foxd1-positive cells, performed in vitro endothelial cell tubulogenesis assays and examined for endocytosis of acetylated low-density lipoprotein (Ac-LDL), a functional assay for endothelial cells. Immunofluorescence and FACS revealed that a subset of Foxd1-positive cells from kidney and lung co-expressed endothelial cell markers throughout embryogenesis. In vitro, cultured embryonic Foxd1-positive cells were able to differentiate into tubular networks that expressed endothelial cell markers and were able to endocytose Ac-LDL. IF and FACS in both the kidney and lung revealed that lineage-tagged Foxd1-positive cells gave rise to a significant portion of the endothelium in postnatal mice. In the kidney, the stromal-derived cells gave rise to a portion of the peritubular capillary endothelium, but not of the glomerular or large vessel endothelium. These findings reveal the heterogeneity of endothelial cell lineages; moreover, Foxd1-positive mesenchymal cells of the developing kidney and lung are a source of endothelial progenitors that are likely critical to patterning the vasculature. © 2013 Sims-Lucas et al
Stable transformation of tobacco by electroporation: evidence for plasmid concatenation.
Goals, Strategies and First Discoveries of AO327, the Arecibo All-Sky 327 MHz Drift Pulsar Survey
We report initial results from AO327, a drift survey for pulsars with the
Arecibo telescope at 327 MHz. The first phase of AO327 will cover the sky at
declinations of -1 to 28 degrees, excluding the region within 5 degrees of the
Galactic plane, where high scattering and dispersion make low-frequency surveys
sub-optimal. We record data from a 57 MHz bandwidth with 1024 channels and 125
us sampling time. The 60 s transit time through the AO327 beam means that the
survey is sensitive to very tight relativistic binaries even with no
acceleration searches. To date we have detected 44 known pulsars with periods
ranging from 3 ms to 2.21 s and discovered 24 new pulsars. The new discoveries
include three millisecond pulsars, three objects with periods of a few tens of
milliseconds typical of young as well as mildly recycled pulsars, a nuller, and
a rotating radio transient. Five of the new discoveries are in binary systems.
The second phase of AO327 will cover the sky at declinations of 28 to 38
degrees. We compare the sensitivity and search volume of AO327 to the Green
Bank North Celestial Cap survey and the GBT350 drift survey, both of which
operate at 350 MHz.Comment: Accepted for publication in Ap
Bulk phase behaviour of binary hard platelet mixtures from density functional theory
We investigate isotropic-isotropic, isotropic-nematic and nematic-nematic
phase coexistence in binary mixtures of circular platelets with vanishing
thickness, continuous rotational degrees of freedom and radial size ratios
up to 5. A fundamental measure density functional theory, previously
used for the one-component model, is proposed and results are compared against
those from Onsager theory as a benchmark. For the system
displays isotropic-nematic phase coexistence with a widening of the biphasic
region for increasing values of . For size ratios , we
find demixing into two nematic states becomes stable and an
isotropic-nematic-nematic triple point can occur. Fundamental measure theory
gives a smaller isotropic-nematic biphasic region than Onsager theory and
locates the transition at lower densities. Furthermore, nematic-nematic
demixing occurs over a larger range of compositions at a given value of
than found in Onsager theory. Both theories predict the same
topologies of the phase diagrams. The partial nematic order parameters vary
strongly with composition and indicate that the larger particles are more
strongly ordered than the smaller particles
Pulsar J0453+1559: A Double Neutron Star System with a Large Mass Asymmetry
To understand the nature of supernovae and neutron star (NS) formation, as
well as binary stellar evolution and their interactions, it is important to
probe the distribution of NS masses. Until now, all double NS (DNS) systems
have been measured to have a mass ratio close to unity (q 0.91). Here we
report the measurement of the individual masses of the 4.07-day binary pulsar
J0453+1559 from measurements of the rate of advance of periastron and Shapiro
delay: The mass of the pulsar is 1.559(5) and that of its companion
is 1.174(4) ; q = 0.75. If this companion is also a neutron star
(NS), as indicated by the orbital eccentricity of the system (e=0.11), then its
mass is the smallest precisely measured for any such object. The pulsar has a
spin period of 45.7 ms and a spin derivative of 1.8616(7) x; from these
we derive a characteristic age of ~ 4.1 x years and a magnetic field of
~ 2.9 x G,i.e, this pulsar was mildly recycled by accretion of matter
from the progenitor of the companion star. This suggests that it was formed
with (very approximately) its current mass. Thus NSs form with a wide range of
masses, which is important for understanding their formation in supernovae. It
is also important for the search for gravitational waves released during a
NS-NS merger: it is now evident that we should not assume all DNS systems are
symmetric
New Discoveries from the Arecibo 327 MHz Drift Pulsar Survey Radio Transient Search
We present Clusterrank, a new algorithm for identifying dispersed
astrophysical pulses. Such pulses are commonly detected from Galactic pulsars
and rotating radio transients (RRATs), which are neutron stars with sporadic
radio emission. More recently, isolated, highly dispersed pulses dubbed fast
radio bursts (FRBs) have been identified as the potential signature of an
extragalactic cataclysmic radio source distinct from pulsars and RRATs.
Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo
327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range pc cm and periods in the range s. The new
pulsars have DMs in the range pc cm and periods in the
range s, and include two nullers and a mode-switching object.
We estimate an upper limit on the all-sky FRB rate of day for
bursts with a width of 10 ms and flux density mJy. The DMs of all
new discoveries are consistent with a Galactic origin. In comparing statistics
of the new RRATs with sources from the RRATalog, we find that both sets are
drawn from the same period distribution. In contrast, we find that the period
distribution of the new pulsars is different from the period distributions of
canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a
periodicity search. This indicates that Clusterrank is a powerful complement to
periodicity searches and uncovers a subset of the pulsar population that has so
far been underrepresented in survey results and therefore in Galactic pulsar
population models.Comment: 41 pages, 16 figures, 4 tables, accepted by ApJ; added minor
corrections to final ApJ proo
An electron Talbot interferometer
The Talbot effect, in which a wave imprinted with transverse periodicity
reconstructs itself at regular intervals, is a diffraction phenomenon that
occurs in many physical systems. Here we present the first observation of the
Talbot effect for electron de Broglie waves behind a nanofabricated
transmission grating. This was thought to be difficult because of Coulomb
interactions between electrons and nanostructure gratings, yet we were able to
map out the entire near-field interference pattern, the "Talbot carpet", behind
a grating. We did this using a Talbot interferometer, in which Talbot
interference fringes from one grating are moire'-filtered by a 2nd grating.
This arrangement has served for optical, X-ray, and atom interferometry, but
never before for electrons. Talbot interferometers are particularly sensitive
to distortions of the incident wavefronts, and to illustrate this we used our
Talbot interferometer to measure the wavefront curvature of a weakly focused
electron beam. Here we report how this wavefront curvature demagnified the
Talbot revivals, and we discuss applications for electron Talbot
interferometers.Comment: 5 pages, 5 figures, updated version with abstrac
Filmic geographies: audio-visual, embodied-material
Although conventionally described as a ‘visual’ method, film-making is also increasingly used within research on embodiment. However, much remains to be said about the ability of filmic methods to enhance researchers’ capacity to think and research through the body. Drawing on my experience of making four research films, in this paper, I attempt to advance this agenda in three steps. First, I introduce anthropological work on the filming body to shed light on the technologically-mediated encounters that enfold around a camera and discuss how they might inform geographical thinking. Second, I describe the corporeally-mediated object ecologies that take shape within the filming setting and highlight how a camera might make objects ‘speak’. Finally, I discuss the affective dimension of screening research films to research participants and the contribution of such intense events to the articulation of collective matters of concerns. Through these three themes, I make the case for understanding knowledge production as located not merely in encounters with filmed audio-visual content, but also in the embodied-material encounters of bodies and objects around the filming and screening apparatus. I finally discuss the implications of these reflections for conceptualising the ‘body’ within embodied methods in social and cultural geography
Clinical outcome data for symptomatic breast cancer: the breast cancer clinical outcome measures (BCCOM) project
Background: Data collection for screen-detected breast cancer in the UK is fully funded which has led to improvements in clinical practice. However data on symptomatic breast cancer are deficient, and the aim of this project was to monitor the current practice.
Methods: A data set was designed together with surrogate outcome measures to reflect best practice. Data from cancer registries initially required the consent of clinicians, but in the third year anonymised data were available.
Results: The quality of data improved but this varied by region and only a third of cases were validated by clinicians. Regional variations in mastectomy rates were identified and one third of patients who underwent conservative surgery for invasive breast cancer were not recorded as receiving radiotherapy.
Conclusions: National data are essential to ensure that all patients receive appropriate treatment for breast cancer, but variations still exist in the UK and further improvement in data capture is required
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