International remittance flows and the economic and social consequences of COVID-19

One of the possible consequences of the tightening of international borders during and after pandemic COVID-19 is what the World Economic Forum refers to as the ‘throttling’ of international (labour) migration. While this will have a profound macroeconomic impact on the global economy, the potential impact on remittances on families, communities and national economies could be equally marked. We present a chord diagram to visualize the latest inter- (and intra-) regional global data on international remittances. This graphic shows the degree of the interconnectedness of the ‘global economy of work’ and the extent to which negative health, economic, social or political changes for migrants in one territory will have profound consequences far across the world

China's low fertility may not hinder future prosperity

China’s low fertility is often presented as a major factor which will hinder its prosperity in the medium to long term. This is based on the assumed negative consequences of an increasing old-age dependency ratio: a simplistic measure of relative changing age structures. Based on this view, policies to increase fertility are being proposed after decades of birth restriction policies. Here, we argue that a purely age structure–based reasoning which disregards labor force participation and education attainment may be highly misleading. While fertility has indeed fallen to low levels, human capital accumulation has been very strong—especially among younger cohorts. Factoring in the effects of labor force participation and educational attainment on productivity, a measure called “productivity-weighted labor force dependency ratio” can more accurately capture the economic implications of demographic change. When using this ratio, a much more optimistic picture of the economic (and social) future of China can be envisaged

Reframing policy responses to population aging in Iran

Iran is aging rapidly and is expected to see negative population growth rates later this century. This change is generating significant concern for policymakers, whose response is to seek ‘demographic solutions’ to these issues: raise the fertility rate, decrease the divorce rate, and promote marriage among young people. Part of these policies has entailed curtailing access to free family planning services. This ‘call and response’ approach is unlikely to succeed in its stated aim, as it over-simplifies the real challenges of population aging as well as the multiple dimensions of population change. Such policies derive from simple representations of demographic change, most notably using the old-age dependency ratio. Using a microsimulation model, this paper suggests that increasing Iran’s currently low female labor force participation and translating educational gains into rising productivity is a more effective means of responding to the challenges of population aging, even under low fertility conditions. The advancement on previous such microsimulation exercises lies in the fact that this study explicitly considers the comparison between raising fertility and increasing female economic empowerment to offset population aging in a setting characterized by an overt pronatalist policy system. In tandem with reforming stressed institutional systems (such as the pension system), releasing the full potential of Iran’s existing (and future) human capital—especially of its women—is a far more effective policy direction than fertility-promoting policies

CELL-TO-CELL INTERACTION IN THE IMMUNE RESPONSE : VII. REQUIREMENT FOR DIFFERENTIATION OF THYMUS-DERIVED CELLS

Experiments were designed to test the possibility that thymus-derived (T) cells cooperate with nonthymus derived (B) cells in antibody responses by acting as passive carriers of antigen. Thoracic duct lymphocytes (TDL) from fowl γG-tolerant mice were incubated in vitro with fowl anti-mouse lymphocyte globulin (FALG), which was shown not to be immunosuppressive in mice. On transfer into adult thymectomized, irradiated, and marrow protected (TxBM) hosts together with a control antigen, horse RBC, a response to horse RBC but not to fowl γG was obtained. By contrast, TxBM recipients of nontolerant, FALG-coated TDL responded to both antigens and the antibody-forming cells were shown to be derived from the host, not from the injected TDL. These findings suggested that, under the conditions of the experiment, triggering of unprimed B cells in the spleens of TxBM hosts was not achieved with antigen-coated tolerant lymphocytes. Another model utilized the ability of B cells to bind antibody-antigen complexes. Spleen cells from TxBM mice, incubated in vitro with anti-fowl γG-fowl γG·NIP, were injected with or without normal TDL (a source of T cells) into irradiated hosts. Only mice given both cell types could produce an anti-NIP antibody response. In a further experiment, spleen cells from HGG·NIP-primed mice were injected together with NIP-coated B cells (prepared as above) into irradiated hosts. A substantial anti-NIP antibody response occurred. If, however, the T cells in the spleens of HGG·NIP-primed mice were eliminated by treatment with anti-θ serum and complement, the NIP response was abolished. It was concluded that antigen-coated B cells could not substitute for T cells either in the primary or secondary response. Treatment of T cells from unprimed or primed mice with mitomycin C impaired their capacity to collaborate with B cells on transfer into irradiated hosts. Taken together these findings suggest that before collaboration can take place T cells must be activated by antigen to differentiate and in so doing may produce some factor essential for triggering of B cells

Measuring Human Capital with Productivity-Weighted Labor Force: Methodology and Projections for China, India, the United States, and the European Union

This working paper provides a comprehensive overview of the methodology used to calculate a standardized and internationally comparable productivity-weighted labor force (PWLF) measure that takes into account both the education structure of the population and the quality of the educational system. Education-specific weights are calculated with a Mincerian earnings function on pooled data from all IPUMS-I censuses containing information on education, labor force status, and income. The education parameters are interacted with the countries' average educational attainment to account for the dependence of returns to education on the number of workers sharing that education level. Country and time specific adjustment factors for education quality are derived from skills assessment surveys. To calculate the productivity-weighted labor force size, these adjusted weights are then applied to labor force estimates and projections. The analytical value of the PWLF is validated making use of prediction exercise for GDP growth applied to a panel dataset covering all countries of the world from 1970 to 2015 for which data are available. Finally, the paper provides a practical application by forecasting PWLF figures for China, India, the United States, and the European Union from 2020 to 2100. These forecasts are compared against other population indicators (total population size, working-age population, and labor force size), highlighting the importance of population heterogeneity in the analysis of demographic trends

Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

Seminoma is a subclass of human testicular germ cell tumors (TGCT), the most frequently observed cancer in young men with a rising incidence. Here we describe the identification of a novel gene predisposing specifically to seminoma formation in a vertebrate model organism. Zebrafish carrying a heterozygous nonsense mutation in Leucine-Rich Repeat Containing protein 50 (lrrc50 also called dnaaf1), associated previously with ciliary function, are found to be highly susceptible to the formation of seminomas. Genotyping of these zebrafish tumors shows loss of heterozygosity (LOH) of the wild-type lrrc50 allele in 44.4% of tumor samples, correlating with tumor progression. In humans we identified heterozygous germline LRRC50 mutations in two different pedigrees with a family history of seminomas, resulting in a nonsense Arg488* change and a missense Thr590Met change, which show reduced expression of the wild-type allele in seminomas. Zebrafish in vivo complementation studies indicate the Thr590Met to be a loss-of-function mutation. Moreover, we show that a pathogenic Gln307Glu change is significantly enriched in individuals with seminoma tumors (13% of our cohort). Together, our study introduces an animal model for seminoma and suggests LRRC50 to be a novel tumor suppressor implicated in human seminoma pathogenesis

Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers

We have previously reported that supplementation with folic acid (1.2 mg day−1 for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA stability in a cohort, which is not folate deficient. Preintervention, there was a significant inverse association between uracil misincorporation in lymphocyte DNA and red cell folate (P<0.05). In contrast, there were no associations between folate status and DNA strand breakage, global DNA methylation or DNA base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex vivo). Folate supplementation elicited a significant reduction in uracil misincorporation (P<0.05), while DNA strand breakage and global DNA methylation remained unchanged. Increasing folate status significantly decreased the base excision repair capacity in those volunteers with the lowest preintervention folate status (P<0.05). Uracil misincorporation was more sensitive to changes in folate status than other measures of DNA stability and therefore could be considered a specific and functional marker of folate status, which may also be relevant to cancer risk in healthy people

Wrist fracture management and the role of surgical care practitioner through the patient’s journey

The presentation of this case study involves an exploration of the patient's journey in detail after having a traumatic wrist fracture, which is recognised as one of the most common fractures encountered daily in emergency services by junior doctors and practitioners. However, this article not only analyses the medical guidance for this type of case, but also the importance of the surgical care practitioner role in trauma and orthopaedics. All practitioners attending patients in emergency services are required to develop a good knowledge of anatomy, physiology, patient’s examination technique, classifications and consequently being aware of the possible surgical options for treatment of the fracture. They will also need to fully understand the legal implications of consent to ensure safe practice