Interaction of Curves Proposed for Design and Analysis of Hollow Reinforced Concrete Columns

This Study is aimed to present a simplified approach enable to construction of a new design charts for hollow section reinforced concrete columns subjected to an axial compressive load and uniaxial bending. These design charts can be used directly in the analysis and design of hollow section columns. These charts can be used in design to determine the required amount of steel reinforcing in addition to the required column dimensions, while in the analysis by using these charts; the column load capacity can be estimated. Two design examples are given to explain the use of the new design charts. It has been shown by these examples that the new proposed charts are very simple to use in structural design applications

In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis

Opioids are widely misused and account for almost half of overdose deaths in the United States. The cost in terms of lives, health care, and lost productivity is significant and has been declared a national crisis. Fentanyl is a highly potent mu opioid receptor (MOR) agonist and plays a significant role in the current opioid epidemic; fentanyl and its analogs (fentalogs) are increasingly becoming one of the biggest dangers in the opioid crisis. The availability of fentalogs in the illicit market is thought to play a significant role in the recent increase in opioid‐related deaths. Although there is both rodent homolog in vivo and in vitro data for some fentalogs, prior to this publication very little was known about the pharmacology of many of these illicit compounds at the human MOR (hMOR). Using gas chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy, and in vitro assays, this study describes the spectral and pharmacological properties of 34 fentalogs. The reported spectra and chemical data will allow for easy identification of novel fentalogs in unknown or mixed samples. Taken together these data are useful for law enforcement and clinical workers as they will aid in the identification of fentalogs in unknown samples and can potentially be used to predict physiological effects after exposure.This study reports the basic in vitro pharmacology (affinity, agonist activity, and potencies) of 34 fentanyl analogs at the human mu opioid receptor. In addition, these fentalogs are analyzed spectroscopically using gas chromatography–mass spectrometry and proton nuclear magnetic resonance spectroscopy, to understand structural commonalities and key differences for identification.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156439/2/dta2822.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156439/1/dta2822_am.pd

Herbivore-induced shifts in carbon and nitrogen allocation in red oak seedlings

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65993/1/j.1469-8137.2008.02420.x.pd

Factors Affecting the Slenderness Limit for RC Columns-The Use of the (ACI-318M-05) Provisions

The current ACI code and many other codes permit the moment magnification method for design of slender reinforced concrete (RC) columns. Manually, the design/analysis procedure is tedious, so that the codes state a pre-prediction if the column is slender or not. In other words, before starting design codes provide slenderness limits to be considered to decide whether a column is slender or not. This work will concentrate on the slender RC column provisions of the latest ACI Code. Using this method some columns are found to be short. In the proposed method of this work, it is found that some of these short columns are found to be long , thus needing moment magnification. Since column analysis/design represents dealing with one of the most critical parts of RC buildings, this proposed magnification is presented in this work

Antioxidant activity of twenty five plants from Colombian biodiversity

The antioxidant activity of the crude n-hexane, dichloromethane, and methanol extracts from 25 species belonging to the Asteraceae, Euphorbiaceae, Rubiaceae, and Solanaceae families collected at natural reserves from the Eje Cafetero Ecorregión Colombia, were evaluated by using the spectrophotometric 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging method. The strongest antioxidant activities were showed by the methanol and dichloromethane extracts from the Euphorbiaceae, Alchornea coelophylla (IC50 41.14 mg/l) and Acalypha platyphilla (IC50 111.99 mg/l), respectively. These two species had stronger DPPH radical scavenging activities than hydroquinone (IC50 151.19 mg/l), the positive control. The potential use of Colombian flora for their antioxidant activities is discussed