6 research outputs found
Numerical homogenization methods for parabolic monotone problems
In this paper we review various numerical homogenization methods for monotone parabolic problems with multiple scales. The spatial discretisation is based on finite element methods and the multiscale strategy relies on the heterogeneous multiscale method. The time discretization is performed by several classes of Runge-Kutta methods (strongly A-stable or explicit stabilized methods). We discuss the construction and the analysis of such methods for a range of problems, from linear parabolic problems to nonlinear monotone parabolic problems in the very general Lp(W1,p) setting. We also show that under appropriate assumptions, a computationally attractive linearized method can be constructed for nonlinear problems
Détermination du débit de filtration glomérulaire au cours de la drépanocytose au Sénégal: Schwartz, Cockcroft et Gault, MDRD, CKD-EPI ou JSCCS ?
La dĂ©termination du DĂ©bit de Filtration GlomĂ©rulaire (DFG) est importante chez les drĂ©panocytaires du fait quâils constituent un groupe de patients chez lesquels des atteintes rĂ©nales sont frĂ©quemment dĂ©crites notamment lâhyperfiltration glomĂ©rulaire. DĂšs lors, Ă une Ă©poque oĂč les calculateurs en ligne proposent simultanĂ©ment diffĂ©rentes formules de dĂ©termination du DFG, il serait important dâĂ©valuer au sein dâune population noire africaine drĂ©panocytaire lâĂ©quivalence entre ces formules qui ont Ă©tĂ© dĂ©veloppĂ©es et validĂ©es sur des populations caucasiennes et afro-amĂ©ricaines Ă DFG normal ou diminuĂ©. Ainsi cette Ă©tude avait pour but dâĂ©valuer lâinterchangeabilitĂ© des diffĂ©rentes formules de dĂ©termination du DFG en les appliquant Ă des drĂ©panocytaires. Des enfants et adultes sĂ©nĂ©galais drĂ©panocytaires homozygotes ont Ă©tĂ© alors recrutĂ©s et leur DFG calculĂ©. La frĂ©quence de lâhyperfiltration glomĂ©rulaire et celle de lâinsuffisance rĂ©nale ont Ă©tĂ© calculĂ©es Ă partir des rĂ©sultats obtenus avec les formules de Schwartz et du CKD-EPI. La concordance des diffĂ©rentes formules a Ă©tĂ© Ă©valuĂ©e avec la mĂ©thode Bland-Altman. Au total 56 adultes et 62 enfants ont Ă©tĂ© inclus dans lâĂ©tude. Lâinsuffisance rĂ©nale a Ă©tĂ© notĂ©e chez 1,78% des adultes et 9,68% des enfants ; lâhyperfiltration glomĂ©rulaire chez 66,10% des adultes et 25,8% des enfants. Par rapport aux formules de rĂ©fĂ©rence (CKD-EPI, Schwartz), tous les biais relevĂ©s Ă©taient significativement diffĂ©rents de zĂ©ro Ă lâexception de celui de Cockcroftet Gault qui Ă©tait statistiquement nul. Les limites de concordance Ă©taient toutes inacceptablement larges par rapport aux limites attendues Ă lâexception de celles du CKD-EPI sans ajustement sur la race. Ainsi, la formule de Schwartz nâĂ©tait pas interchangeable avec celle du JSCCS chez les enfants, tout comme celle du CKD-EPI ne lâĂ©tait pas non plus avec celles du JSCCS, de Cockcroft, du MDRD ou du CKD-EPI sans ajustement sur la race chez les adultes drĂ©panocytaires.
English title: Determination of glomerular filtration rate in sickle cell disease in Senegal: Schwartz, Cockcroft and Gault, MDRD, CKD-EPI or JSCCS?
Determination of Glomerular Filtration Rate (GFR) is important in patients living with sickle cell disease (SCD) because they constitute a group of patients where kidney dysfunction is frequently described, in particular glomerular hyperfiltration. Therefore, at a time when online calculators simultaneously propose different formulas to estimate GFR, it would be important to evaluate in a black African population living with SCD the equivalence between these formulas which have been developed and validated on Caucasian and African American populations with normal or decreased GFR. Thus, the aim of this study was to evaluate interchangeability of different GFR formulas in a group of patients living with SCD. Homozygous Senegalese sickle cell children and adults were then recruited and their GFR computed using Schwartz and JSCCS in children, Cockcroft and Gault, CKD-EPI with and without adjustment for ethnicity, MDRD and JSCCS formulas in adults. The frequency of glomerular hyperfiltration and renal failure was computed based on the results generated using Schwartz and CKD-EPI formulas. The agreement between formulas was assessed with BlandAltman method. A total of 56 adults and 62 children were included in this study. Renal failure was observed in 1.78% of adults and 9.68% of children; glomerular hyperfiltration in 66.10% of adults and 25.8% of children. Compared with reference formulas (CKD-EPI, Schwartz), all biases found were significantly different from zero except for Cockcroft and Gault formula bias, which was statistically zero. The limits of agreement were all unacceptably wide compared with the expected limits with the exception of CKD-EPI without adjustment for ethnicity. Thus, Schwartz formula would not be interchangeable with JSCCS formula in children, nor was the CKD-EPI formula interchangeable with the JSCCS, Cockcroft and Gault, MDRD or CKD-EPI without adjustment for ethnicity formulas in adults living with sickle cell anemia
16S Metagenomic Comparison of Plasmodium falciparumâInfected and Noninfected Anopheles gambiae and Anopheles funestus Microbiota from Senegal
International audienc
Chilling, irradiation and transport of male Glossina palpalis gambiensis pupae: Effect on the emergence, flight ability and survival
International audienceBackground The sterile insect technique (SIT) requires mass-rearing of the target species, irradiation to induce sexual sterility and transportation from the mass-rearing facility to the target site. Those treatments require several steps that may affect the biological quality of sterile males. This study has been carried out to evaluate the relative impact of chilling, irradiation and transport on emergence rate, flight ability and survival of sterile male Glossina palpalis gambiensis. Results Chilling, irradiation and transport all affected the quality control parameters studied. The emergence rate was significantly reduced by long chilling periods and transport, i.e. from 92% at the source insectary in Burkina Faso to 78% upon arrival in Senegal. Flight ability was affected by all three parameters with 31% operational flies lost between the production facility and the destination site. Only survival under stress was not affected by any of the treatments. Conclusion The chilling period and transport were the main factors that impacted significantly the quality of sterile male pupae. Therefore, in the operational programme, the delivery of sterile male pupae was divided over two shipments per week to reduce the chilling time and improve the quality of the sterile males. Quality of the male pupae may further be improved by reducing the transport time and vibrations during transport