Negotiating requests for reimbursement for community engagement: challenges in developing an educational video for genomic biobanking research in South Africa

Genomic research and the biobanking capacity it requires are experiencing considerable growth on the continent of Africa. However genomic research and biobanking raise a range of legal, ethical, social, and cultural issues, including concerns about broad consent, confidentiality, community stigmatization, discrimination, indefinite storage, and long-term use. There is a need to establish governance frameworks that address these issues, and many international health research ethics and biobanking guidelines now recommend that the best way to do so is by involving potential research participants and key community stakeholders in the research development and the process of acquiring samples and data through active community engagement (CE). This article describes the experience and challenges in developing an educational tool as part of a CE initiative in South Africa and the commentaries reflect on how this process may be improved going forward

The neutron star soft X-ray transient 1H1905+000 in quiescence

In this Paper we report on our analysis of a ~25 ksec. Chandra X-ray observation of the neutron star soft X-ray transient (SXT) 1H1905+000 in quiescence. Furthermore, we discuss our findings of the analysis of optical photometric observations which we obtained using the Magellan telescope and photometric and spectroscopic observations which we obtained using the Very Large Telescope at Paranal. The X-ray counterpart of 1H1905+000 was not detected in our Chandra data, with a 95 per cent confidence limit to the source count rate of 1.2x10^-4 counts s^-1. For different spectral models this yields an upper limit on the luminosity of 1.8x10^31 erg s^-1 (for an upper limit on the distance of 10 kpc.) This luminosity limit makes 1H1905+000 the faintest neutron star SXT in quiescence observed to date. The neutron star luminosity is so low that it is similar to the lowest luminosities derived for black hole SXTs in quiescence. This low luminosity for a neutron star SXT challanges the hypothesis presented in the literature that black hole SXTs in quiescence have lower luminosities than neutron star SXTs as a result of the presence of a black hole event horizon. Furthermore, the limit on the neutron star luminosity obtained less than 20 years after the outburst has ceased, constrains the thermal conductivity of the neutron star crust. Finally, the neutron star core must be so cold that unless the time averaged mass accretion rate is lower than 2x10^-12 M_sun yr^-1, core cooling has to proceed via enhanced neutrino emission processes. We derive a limit on the absolute I-band magnitude of the quiescent counterpart of M_I>7.8 assuming the source is at 10 kpc. This is in line with 1H1905+000 being an ultra-compact X-ray binary, as has been proposed based on the low outburst V-band absolute magnitude.Comment: 10 pages, 5 figures, accepted for publication in MNRA

A Search for Single Radio Pulses and Bursts from Southern AXPs

We observed four southern AXPs in 1999 near 1400 MHz with the Parkes 64-m radio telescope to search for periodic radio emission. No Fourier candidates were discovered in the initial analysis, but the recent radio activity observed for the AXP XTE J1810-197 has prompted us to revisit these data to search for single radio pulses and bursts. The data were searched for both persistent and bursting radio emission at a wide range of dispersion measures, but no detections of either kind were made. These results further weaken the proposed link between rotating radio transient sources and magnetars. However, continued radio searches of these and other AXPs at different epochs are warranted given the transient nature of the radio emission seen from XTE J1810-197, which until very recently was the only known radio-emitting AXP.Comment: 3 pages, including 1 table. To appear in the proceedings of "40 Years of Pulsars: Millisecond Pulsars, Magnetars, and More", August 12-17, 2007, McGill University, Montreal, Canad

An approach to the diagnosis and management of multiple myeloma

Multiple myeloma (MM) is a plasma cell dyscrasia that accounts for ~10% of haematological malignancies. It is a disease of the elderly, with a slight male predominance. Almost all cases of MM are preceded by an asymptomatic, premalignant phase known as monoclonal gammopathy of undetermined significance (MGUS). The clinical presentation of MM may be nonspecific, with the most common presenting symptoms being fatigue, bone pain and anaemia. The diagnostic criteria for MM were revised in 2014 to include 3 specific biomarkers of malignancy that are associated with an increased risk of target organ damage. This has resulted in a paradigm shift in the management of MM. The introduction of immunomodulatory agents and proteasome inhibitors has significantly improved the survival of patients with MM. Autologous stem cell transplantation remains the standard of care in younger, fit patients, where there is also a clear role for maintenance chemotherapy. Transplant-ineligible patients benefit from a prolonged induction therapy, and the role of maintenance therapy in this setting is still unclear. Despite major advances in therapy, MM remains an incurable malignant condition and novel agents such as monoclonal antibodies play an important role, especially in the elderly and patients who have relapsed

Proper motions of ROSAT discovered isolated neutron stars measured with Chandra: First X-ray measurement of the large proper motion of RX J1308.6+2127/RBS 1223

The unprecedented spatial resolution of the Chandra observatory opens the possibility to detect with relatively high accuracy proper motions at X-ray wavelengths. We have conducted an astrometric study of three of the "Magnificent Seven", the thermally emitting radio quiet isolated neutron stars (INSs) discovered by ROSAT. These three INSs (RX J0420.0-5022, RX J0806.4-4123 and RX J1308.6+2127/RBS 1223) either lack an optical counterpart or have one too faint to be used for astrometric purposes. We obtained ACIS observations 3 to 5 years apart to constrain or measure the displacement of the sources on the X-ray sky using as reference the background of extragalactic or remote galactic X-ray sources. Upper limits of 138 mas/yr and 76 mas/yr on the proper motion of RX J0420.0-5022 and RX J0806.4-4123, respectively, have already been presented in Motch et al. (2007). Here we report the very significant measurement (~ 10 sigma) of the proper motion of the third INS of our program, RX J1308.6+2127/RBS1223. Comparing observations obtained in 2002 and 2007 reveals a displacement of 1.1 arcsec implying a yearly proper motion of 223 mas, the second fastest measured for the ROSAT discovered INSs. The source is rapidly moving away from the galactic plane at a speed which precludes any significant accretion of matter from the interstellar medium. Its transverse velocity of ~ 740 (d/700pc) km/s might be the largest of the "Magnificent Seven" and among the fastest recorded for neutron stars. RX J1308.6+2127/RBS1223 is thus a young high velocity cooling neutron star. The source may have its origin in the closest part of the Scutum OB2 association about 0.8 Myr ago, an age consistent with that expected from cooling curves, but significantly younger than inferred from pulse timing measurements (1.5 Myr).Comment: 3 pages, 2 figures, proceedings of the conference "40 Years of Pulsars", 12-17 August 2007, Montreal, Canad

Space cowboys odyssey: beyond the Gould Belt

We present our new advanced model for population synthesis of close-by cooling NSs. Detailed treatment of the initial spatial distribution of NS progenitors and a detailed ISM structure up to 3 kpc give us an opportunity to discuss the strategy to look for new isolated cooling NSs. Our main results in this respect are the following: new candidates are expected to be identified behind the Gould Belt, in directions to rich OB associations, in particular in the Cygnus-Cepheus region; new candidates, on average, are expected to be hotter than the known population of cooling NS. Besides the usual approach (looking for soft X-ray sources), the search in 'empty' $\gamma$-ray error boxes or among run-away OB stars may yield new X-ray thermally emitting NS candidates.Comment: 3 pages, 2 figures, proceedings of the conference "40 Years of Pulsars ", 12-17 August 2007, Montreal, Canad

Cataclysmic Variables and Other Compact Binaries in the Globular Cluster NGC 362: Candidates from Chandra and HST

Highly sensitive and precise X-ray imaging from Chandra, combined with the superb spatial resolution of HST optical images, dramatically enhances our empirical understanding of compact binaries such as cataclysmic variables and low mass X-ray binaries, their progeny, and other stellar X-ray source populations deep into the cores of globular clusters. Our Chandra X-ray images of the globular cluster NGC 362 reveal 100 X-ray sources, the bulk of which are likely cluster members. Using HST color-magnitude and color-color diagrams, we quantitatively consider the optical content of the NGC 362 Chandra X-ray error circles, especially to assess and identify the compact binary population in this condensed-core globular cluster. Despite residual significant crowding in both X-rays and optical, we identify an excess population of H{\alpha}-emitting objects that is statistically associated with the Chandra X-ray sources. The X-ray and optical characteristics suggest that these are mainly cataclysmic variables, but we also identify a candidate quiescent low mass X-ray binary. A potentially interesting and largely unanticipated use of observations such as these may be to help constrain the macroscopic dynamic state of globular clusters.Comment: 6 pages, 6 figures, to appear in the proceedings of the conference "Binary Star Evolution: Mass Loss, Accretion, and Mergers," Mykonos, Greece, June 22-25, 201

X-ray and Optical Study of Low Core Density Globular Clusters NGC6144 and E3

We report on the Chandra X-ray Observatory and Hubble Space Telescope observation of two low core density globular clusters, NGC6144 and E3. By comparing the number of X-ray sources inside the half-mass radius to those outside, we found 6 X-ray sources within the half-mass radius of NGC6144, among which 4 are expected to be background sources; 3 X-ray sources are also found within the half-mass radius of E3, of which 3 is expected to be background source. Therefore, we cannot exclude that all our sources are background sources. However, combining the results from X-ray and optical observations, we found that 1-2 sources in NGC6144 and 1 source in E3 are likely to be cataclysmic variables and that 1 source in NGC6144 is an active binary, based on the X-ray and optical properties. The number of faint X-ray sources in NGC6144 and E3 found with Chandra and HST is higher than a prediction based on collision frequency, but is closer to that based on mass. Our observations strongly suggest that the compact binary systems in NGC6144 and E3 are primordial in origin.Comment: 28 pages, 9 figures, 6 tables, Accepted for publication in Ap

Measuring the cosmic ray acceleration efficiency of a supernova remnant

Cosmic rays are the most energetic particles arriving at earth. Although most of them are thought to be accelerated by supernova remnants, the details of the acceleration process and its efficiency are not well determined. Here we show that the pressure induced by cosmic rays exceeds the thermal pressure behind the northeast shock of the supernova remnant RCW 86, where the X-ray emission is dominated by synchrotron radiation from ultra-relativistic electrons. We determined the cosmic-ray content from the thermal Doppler broadening measured with optical spectroscopy, combined with a proper-motion study in X- rays. The measured post-shock proton temperature in combination with the shock velocity does not agree with standard shock heating, implying that >50% of the post-shock pressure is produced by cosmic rays.Comment: Published in Science express, 10 pages, 5 figures and 2 table