Proyecto de rehabilitación y cambio de actividad de una nave

[ES] Este trabajo reúne y aplica toda la documentación necesaria para la elaboración de un proyecto de reforma de una nave industrial situada en la localidad de Moncada (Valencia). Para su desarrollo, ha sido imprescindible la utilización y cumplimiento de la normativa correspondiente vigente, así como la descripción de todos los elementos constructivos necesarios empleados en la reforma. Del mismo modo, para su elaboración ha sido necesaria también la utilización de todos los conocimientos teóricos y prácticos estudiados en el Grado de Arquitectura Técnica.Bascuñana Casero, RJ. (2019). Proyecto de rehabilitación y cambio de actividad de una nave. http://hdl.handle.net/10251/134094TFG

La vinificación mediante el exclusivo empleo de la asepsia industrial

Copia digital : Diputación de Málaga. Biblioteca Cánovas del Castillo, 201

FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration

IntroductionThe Addenbrooke’s Cognitive Examination III (ACE-III) is a brief test useful for neuropsychological assessment. Several studies have validated the test for the diagnosis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, we aimed to examine the metabolic correlates associated with the performance of ACE-III in AD and behavioral variant FTD.MethodsWe enrolled 300 participants in a cross-sectional study, including 180 patients with AD, 60 with behavioral FTD (bvFTD), and 60 controls. An 18F-Fluorodeoxyglucose positron emission tomography study was performed in all cases. Correlation between the ACE-III and its domains (attention, memory, fluency, language, and visuospatial) with the brain metabolism was estimated.ResultsThe ACE-III showed distinct neural correlates in bvFTD and AD, effectively capturing the most relevant regions involved in these disorders. Neural correlates differed for each domain, especially in the case of bvFTD. Lower ACE-III scores were associated with more advanced stages in both disorders. The ACE-III exhibited high discrimination between bvFTD vs. HC, and between AD vs. HC. Additionally, it was sensitive to detect hypometabolism in brain regions associated with bvFTD and AD.ConclusionOur study contributes to the knowledge of the brain regions associated with ACE-III, thereby facilitating its interpretation, and highlighting its suitability for screening and monitoring. This study provides further validation of ACE-III in the context of AD and FTD

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Análisis, diseño y desarrollo de una aplicación informática para la resolución del problema de patrones de corte en una empresa de fabricación de cartón ondulado

[ES] El presente Trabajo de Fin de Grado pretende desarrollar una aplicación informática para la resolución del problema de recorte de papel que genera la fabricación de planchas (Cutting Stock Problem). Para entender las necesidades actuales de la empresa, se describirá el entorno de la misma y se analizará la situación actual. A continuación, después de realizar un análisis de los requerimientos de usuario, se desarrollarán algoritmos para resolver el problema con el objetivo de generar configuraciones de corte que minimicen la merma generada. Estos algoritmos se implementarán en Microsoft Visual Studio. El resultado de este proceso será una aplicación informática escrita en lenguaje de programación C# que permitirá generar el lanzamiento destinado a la onduladora. Dicho lanzamiento estará compuesto por las órdenes de producción pertinentes para la fabricación de la demanda de las planchas seleccionadas minimizando la merma generada. Para dar soporte a la aplicación se utilizarán bases de datos, seleccionando Microsoft SQL Server como sistema gestor de base de dato. Además, la aplicación desarrollada permitirá al usuario gestionar la información almacenada en la base de datos.[CA] El present Treball de Fi de Grau te la intenció de desenvolupar una aplicació informàtica per a la resolució del problema de retall de paper que genera la fabricació de planxes (Cutting Stock Problem). Per a entendre les necessitats actuals de l'empresa, es descriurà el seu entorn i s'analitzarà la situació actual. Seguidament, desprès de realitzar un anàlisis dels requeriments d'usuari, es desenvoluparan algoritmes per a resoldre el problema amb l'objectiu de generar configuracions de tall que minimitzen el desaprofitament generat. Aquests algoritmes s'implementaran en Microsoft Visual Studio. El resultat d'aquest procés serà una aplicació informàtica escrita en llenguatge de programació C# que permetrà generar el llançament destinat a l'Onduladora. Aquest llançament estarà comport per les ordres de producció pertinents per a la fabricació de la demanda de les planxes seleccionades minimitzant el desaprofitament generat. Per a donar suport a l'aplicació s'utilitzaran bases de dades, seleccionant Microsoft SQL Server com a sistema gestor de la base de dades. A més, l'aplicació desenvolupada permetrà a l'usuari gestionar la informació emmagatzemada en la base de dades[EN] The objective of this Final Project is to develop a computer application with the aim of solving paper cutting problems for generating sheets (Cutting Stock Problem). In order to know the current company's demands, its environment and its current situation will be analyzed. Then, after making customer requirement analysis, some algorithms will be developed to resolve the problem. The objective is to generate cutting configurations which minimize trim. These algorithms will be implemented into Microsoft Visual Studio. The result of this process will be a computer application written in C# programming language. It will allow to generate scheduling for the Corrugator. That scheduling will be formed by production orders which minimize trim to make the sheets that have been selected. Some databases will be used to give support to the application. Microsoft SQL Server has been selected as database management system. Moreover, the computer application will allow customers to manage stored information in database.Bascuñana Catalá, JI. (2018). Análisis, diseño y desarrollo de una aplicación informática para la resolución del problema de patrones de corte en una empresa de fabricación de cartón ondulado. http://hdl.handle.net/10251/114692TFG

Políticas públicas inclusivas para el acceso de las personas con discapacidad al empleo público

El capítulo analiza la evolución de las políticas de empleo y el acceso al mercado laboral de personas con diversidad funcional. Para ello, se realiza un análisis conceptual sobre discapacidad y diversidad, se aborda el marco normativo español, el impacto que sobre él han tenido las convenciones y normativa internacional, para posteriormente adentrarse en las estrategias de política pública en materia de discapacidad y empleo público, así como los instrumentos implementados que han transformado y reconfigurado este mercado laboral. En este ámbito, se pone especial atención en las adaptaciones del acceso al empleo público a personas con diversidad funcional. Para finalizar, se analiza la experiencia del acceso al empleo público y el empleo con apoyo como principal de vía de éxito para la incorporación de personas con diversidad funcional. Se destaca el rol de las entidades sociales durante todo este proceso partiendo del estudio de caso desarrollado por Plena Inclusión Madrid y ASPIMIP.Depto. de Ciencia Política y de la AdministraciónInstituto Complutense de Ciencia de la Administración (ICCA)Fac. de Ciencias Políticas y SociologíaTRUEpu

Sensibilidad de biomarcadores en el líquido cefalorraquídeo en enfermedades neurodegenerativas

Recent advances in the pathophysiology of Alzheimer�s disease has prompted the clinical development of biomarkers that would expand research in early diagnosis, rate of disease progression and monitoring the effect of therapies. Cerebrospinal fluid measures (CSF) of beta-amyloid 42, total tau and phospo- tau proteins have shown a high diagnostic accuracy in differenciating Alzheimer�s dementia from healthy controls, even at very early stages of the disease. Diagnostic accuracy of the biomarkers between Alzheimer�s disease and other dementia types is not as good, although the specificity of phospo-tau levels remains high. Clinical usefulness is limited by the invasiveness of the procedure, and by strict adhesion to a well-defined protocol and sample handling. The type of technical method for determination is not widely established, and variability between centres is high. Nevertheless, there is an important role of CSF biomarkers in selected cases, and in the research of timing the events of Alzheimer�s disease.El avance en el conocimiento de la biología de la enfermedad de Alzheimer ha favorecido el desarrollo clínico de biomarcadores que permitan un diagnóstico temprano, monitoricen la progresión y puedan servir parar la evaluación de terapias. Las determinaciones en el líquido cefalorraquídeo (LCR) de beta-amiloide 42 (BA42), proteína tau total y proteína tau fosforilada han mostrado tener un rendimiento diagnóstico elevado para diferenciar la demencia tipo Alzheimer respecto a controles, incluso en fases incipientes de la misma. El rendimiento respecto a otros tipos de enfermedades neurodegenerativas es más bajo, aunque la especificidad de la tau fosforilada se mantiene para diferenciar la demencia tipo Alzheimer de las otras. La aplicabilidad clínica se encuentra limitada por la necesidad de un procedimiento invasivo, y de un protocolo y adiestramiento técnico en la determinación de específicos. La tecnología de medida todavía no está estandarizada a nivel global y la variabilidad entre centros es alta. Sin embargo, en casos clínicos seleccionados y en la investigación de la patocronia de la enfermedad de Alzheimer, los biomarcadores de LCR juegan un papel importante

Type II intrapancreatic choledochal malignant cyst in adults: duodenopancreatectomy

A 62-year-old female patient was admitted for abdominal pain and vomiting. Imaging tests revealed a solid-cystic lesion at the head of the pancreas communicating with the distal bile duct. A Todani type II choledochal cyst was diagnosed with neoplastic degeneration after cytological diagnosis with endoscopic ultrasound-guided puncture. The patient was treated with a cephalic duodenopancreatectomy with curative intention