A systematic review and economic evaluation of subcutaneous and sublingual allergen immunotherapy in adults and children with seasonal allergic rhinitis

© Queen’s Printer and Controller of HMSO 2013Severe allergic rhinitis uncontrolled by conventional medication can substantially affect quality of life. Immunotherapy involves administering increasing doses of a specific allergen, with the aim of reducing sensitivity and symptomatic reactions. Recent meta-analyses have concluded that both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) are more effective than placebo in reducing symptoms. It is uncertain which route of administration is more effective and whether or not treatment is cost-effective.National Institute for Health Research Health Technology Assessment programm

`Operational' Energy Conditions

I show that a quantized Klein-Gordon field in Minkowski space obeys an `operational' weak energy condition: the energy of an isolated device constructed to measure or trap the energy in a region, plus the energy it measures or traps, cannot be negative. There are good reasons for thinking that similar results hold locally for linear quantum fields in curved space-times. A thought experiment to measure energy density is analyzed in some detail, and the operational positivity is clearly manifested. If operational energy conditions do hold for quantum fields, then the negative energy densities predicted by theory have a will-o'-the-wisp character: any local attempt to verify a total negative energy density will be self-defeating on account of quantum measurement difficulties. Similarly, attempts to drive exotic effects (wormholes, violations of the second law, etc.) by such densities may be defeated by quantum measurement problems. As an example, I show that certain attempts to violate the Cosmic Censorship principle by negative energy densities are defeated. These quantum measurement limitations are investigated in some detail, and are shown to indicate that space-time cannot be adequately modeled classically in negative energy density regimes.Comment: 18 pages, plain Tex, IOP macros. Expanded treatment of measurement problems for space-time, with implications for Cosmic Censorship as an example. Accepted by Classical and Quantum Gravit

Search for correlation effects in linear chains of trapped ions

We report a precise search for correlation effects in linear chains of 2 and 3 trapped Ca+ ions. Unexplained correlations in photon emission times within a linear chain of trapped ions have been reported, which, if genuine, cast doubt on the potential of an ion trap to realize quantum information processing. We observe quantum jumps from the metastable 3d 2D_{5/2} level for several hours, searching for correlations between the decay times of the different ions. We find no evidence for correlations: the number of quantum jumps with separations of less than 10 ms is consistent with statistics to within errors of 0.05%; the lifetime of the metastable level derived from the data is consistent with that derived from independent single-ion data at the level of the experimental errors 1%; and no rank correlations between the decay times were found with sensitivity to rank correlation coefficients at the level of |R| = 0.024.Comment: With changes to introduction. 5 pages, including 4 figures. Submitted to Europhys. Let

Ac conductivity and dielectric properties of CuFe1−xCrxO2 : Mg delafossite

The electrical and dielectric properties of CuFe(1−x)Cr(x)O(2) (0 ≤ x ≤ 1) powders, doped with 3% of Mg and prepared by solid-state reaction, were studied by broadband dielectric spectroscopy in the temperature range from −100 to 150 °C. The frequency-dependent electrical and dielectric data have been discussed in the framework of a power law conductivity and complex impedance and dielectric modulus. At room temperature, the ac conductivity behaviour is characteristic of the charge transport in CuFe1−xCrxO2 powders. The substitution of Fe3+ by Cr3+ results in an increase in dc conductivity and a decrease in the Cu+–Cu+ distance. Dc conductivity, characteristic onset frequency and Havriliak–Negami characteristics relaxation times are thermally activated above −40 °C for x = 0.835. The associated activation energies obtained from dc and ac conductivity and from impedance and modulus losses are similar and show that CuFe1−xCrxO2 delafossite powders satisfy the BNN relation. Dc and ac conductivities have the same transport mechanism, namely thermally activated nearest neighbour hopping and tunnelling hopping above and below −40 °C, respectively

Continental-scale patterns of pathogen prevalence: a case study on the corncrake

Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to examine systems where host genetic diversity is consistent among the populations, thus controlling for any potentially confounding genetic effects. Here, we report geographic variation in haemosporidian infection among European populations of corncrake. This species now occurs in fragmented populations, but there is little genetic structure and equally high levels of genetic diversity among these populations. We observed a longitudinal gradient of prevalence from western to Eastern Europe negatively correlated with national agricultural yield, but positively correlated with corncrake census population sizes when only the most widespread lineage is considered. This likely reveals a possible impact of local agriculture intensity, which reduced host population densities in Western Europe and, potentially, insect vector abundance, thus reducing the transmission of pathogens. We conclude that in the corncrake system, where metapopulation dynamics resulted in variations in local census population sizes, but not in the genetic impoverishment of these populations, anthropogenic activity has led to a reduction in host populations and pathogen prevalence

Effect of composition on the dielectric relaxation of zeolite-conducting polyaniline blends

The complex permittivity of conducting polyaniline and zeolite - polyaniline blends was measured in the frequency range 0.01 to 2000000 Hz from room temperature to liquid nitrogen temperature. A loss peak is detected for 25, 35 and 50 wt % zeolite blends. Its position in the frequency domain, activation energy and intensity is a function of composition. The experimental results are interpreted through the competing multiple role of zeolite: as being less conducting than polyaniline, it impedes the electric charge flow by dividing large conducting polyaniline regions into smaller pieces, subsequently provides short-range pathways and, moreover, enriches the blend in interfaces separating zeolite from polyaniline.Comment: Accepted for publication in J. Appl. Phy

Detection of an atmosphere around the super-Earth 55 Cancri e

We report the analysis of two new spectroscopic observations of the super-Earth 55 Cancri e, in the near infrared, obtained with the WFC3 camera onboard the HST. 55 Cancri e orbits so close to its parent star, that temperatures much higher than 2000 K are expected on its surface. Given the brightness of 55 Cancri, the observations were obtained in scanning mode, adopting a very long scanning length and a very high scanning speed. We use our specialized pipeline to take into account systematics introduced by these observational parameters when coupled with the geometrical distortions of the instrument. We measure the transit depth per wavelength channel with an average relative uncertainty of 22 ppm per visit and find modulations that depart from a straight line model with a 6$\sigma$ confidence level. These results suggest that 55 Cancri e is surrounded by an atmosphere, which is probably hydrogen-rich. Our fully Bayesian spectral retrieval code, T-REx, has identified HCN to be the most likely molecular candidate able to explain the features at 1.42 and 1.54 $\mu$m. While additional spectroscopic observations in a broader wavelength range in the infrared will be needed to confirm the HCN detection, we discuss here the implications of such result. Our chemical model, developed with combustion specialists, indicates that relatively high mixing ratios of HCN may be caused by a high C/O ratio. This result suggests this super-Earth is a carbon-rich environment even more exotic than previously thought.Comment: 10 pages, 10 figures, 4 tables, Accepted for publication in Ap

Observational constraints on Cosmic Reionization

Recent observations have set the first constraints on the epoch of reionization (EoR), corresponding to the formation epoch of the first luminous objects. Studies of Gunn-Peterson (GP) absorption, and related phenomena, suggest a qualitative change in the state of the intergalactic medium (IGM) at $z \sim 6$, indicating a rapid increase in the neutral fraction of the IGM, from $x_{HI} 10^{-3}$, perhaps up to 0.1, at $z \ge 6$. Conversely, transmission spikes in the GP trough, and the evolution of the \lya galaxy luminosity function indicate $x_{HI} < 0.5$ at $z\sim 6.5$, while the large scale polarization of the cosmic microwave background (CMB) implies a significant ionization fraction extending to higher redshifts, $z \sim 11 \pm 3$. The results suggest that reionization is less an event than a process, with the process beginning as early as $z \sim 14$, and with the 'percolation', or 'overlap' phase ending at $z \sim 6$. The data are consistent with low luminosity star forming galaxies as being the dominant sources of reionizing photons. Low frequency radio telescopes currently under construction should be able to make the first direct measurements of HI 21cm emission from the neutral IGM during the EoR, and upcoming measurements of secondary CMB temperature anisotropy will provide fine details of the dynamics of the reionized IGM.Comment: to appear in ARAA 2006, vol 44, page 415-462; latex. 84 pages. 15 fi

Analytic approach to the evolutionary effects of genetic exchange

We present an approximate analytic study of our previously introduced model of evolution including the effects of genetic exchange. This model is motivated by the process of bacterial transformation. We solve for the velocity, the rate of increase of fitness, as a function of the fixed population size, $N$. We find the velocity increases with $\ln N$, eventually saturated at an $N$ which depends on the strength of the recombination process. The analytical treatment is seen to agree well with direct numerical simulations of our model equations