Design and initial testing of a high speed 45 kW switched reluctance drive for aerospace application

This paper presents innovative research towards the development of a 45 kW high speed switched reluctance drive as an alternative starter-generator for future aero-engines. To perform such a function the machine had to be designed with a very wide constant power-speed range. During engine-start/motoring mode, a peak torque demand of 54 Nm at 8 krpm was met, whilst in generating mode, 19.2-32 krpm, the machine was designed to deliver a constant power of 45 kW. The key enabling feature of the design lies in the novel rotor structure developed so as to allow for such a wide speed range. The results presented, are those measured during the initial testing phase and validate the system design and performance in the low-speed region with the machine operated in starting-mode. The measured machine power density is at 9.8 kW/ltr, whilst the global system efficiency is at 82%

An investigation into the geometric parameters affecting field uniformity in four pole magnetisers

In recent years, the field-metric method for measuring the joule losses set up in an electrical steel laminate when subjected to a rotating field has gained popularity. The ideal geometry of the magnetiser required to set up such a field is still however the subject of much debate. The work presented in this paper aims at providing some useful guidelines which might be considered when undertaking the construction of the simplest of such magnetizing setups having four salient poles excited by a two phase system and using a square sample. A 3D model for this rotational power loss tester was simulated for different pole geometries with the induction uniformity being assessed for every alteration

Flux position estimation using current derivatives for the sensorless control of AC machines

This paper considers the general principles of saliency tracking in AC machines. Special attention is given to pulse type injection for the extraction of a rotor or flux position signal. The saliency is tracked by measuring the current derivative resulting from voltage ‘test’ vector application. Results show tracking of ‘saturation’ saliency on a standard induction motor to be used for sensorless control of ac machines in the low and zero speed region.peer-reviewe

An investigation on the performance of current derivative sensors for the sensorless control of AC drives

This paper considers different types of current derivative sensors that may be used for tracking the saturation saliency in a.c. machines. The saliency is tracked by measuring the current derivative resulting from voltage 'test' vector application. The performance of different sensors proposed in the literature is investigated.peer-reviewe

Electrical Machine Topologies: Hottest Topics in the Electrical Machine Research Community

In this article, the state of the art in electrical machine design is outlined underlining the problems and challenges to be solved by engineers. As highlighted in this article, even if electrical machine design is often considered a mature issue from the technical and technological point of view, every year, new progresses and steps forward are made. New and more sophisticated design tools can be used worldwide, and innovative manufacturing processes, new insulation materials, and higher performance magnetic materials are available on the market. In addition, the evolution of the hardware used in digital control and new powerful power electronic devices represents a constant stimulus to improve the performance of electrical machines and reintroduce electrical machine structures that were not adopted in the past due to technological and technical constraints. As shown in this article, electrical machine design is an evergreen topic, and its importance is rising more each year under the push of more energy-saving requirements and higher-efficiency systems for electromechanical conversion. A green world will not be possible without electrical machines

Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease:results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study

BACKGROUND: Anti-drug antibodies are associated with treatment failure to anti-TNF agents in patients with inflammatory bowel disease (IBD).AIM: To assess whether immunogenicity to a patient's first anti-TNF agent would be associated with immunogenicity to the second, irrespective of drug sequence METHODS: We conducted a UK-wide, multicentre, retrospective cohort study to report rates of immunogenicity and treatment failure of second anti-TNF therapies in 1058 patients with IBD who underwent therapeutic drug monitoring for both infliximab and adalimumab. The primary outcome was immunogenicity to the second anti-TNF agent, defined at any timepoint as an anti-TNF antibody concentration ≥9 AU/ml for infliximab and ≥6 AU/ml for adalimumab.RESULTS: In patients treated with infliximab and then adalimumab, those who developed antibodies to infliximab were more likely to develop antibodies to adalimumab, than patients who did not develop antibodies to infliximab (OR 1.99, 95%CI 1.27-3.20, p = 0.002). Similarly, in patients treated with adalimumab and then infliximab, immunogenicity to adalimumab was associated with subsequent immunogenicity to infliximab (OR 2.63, 95%CI 1.46-4.80, p < 0.001). For each 10-fold increase in anti-infliximab and anti-adalimumab antibody concentration, the odds of subsequently developing antibodies to adalimumab and infliximab increased by 1.73 (95% CI 1.38-2.17, p < 0.001) and 1.99 (95%CI 1.34-2.99, p < 0.001), respectively. Patients who developed immunogenicity with undetectable drug levels to infliximab were more likely to develop immunogenicity with undetectable drug levels to adalimumab (OR 2.37, 95% CI 1.39-4.19, p < 0.001). Commencing an immunomodulator at the time of switching to the second anti-TNF was associated with improved drug persistence in patients with immunogenic, but not pharmacodynamic failure.CONCLUSION: Irrespective of drug sequence, immunogenicity to the first anti-TNF agent was associated with immunogenicity to the second, which was mitigated by the introduction of an immunomodulator in patients with immunogenic, but not pharmacodynamic treatment failure

Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease:results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study

BACKGROUND: Anti-drug antibodies are associated with treatment failure to anti-TNF agents in patients with inflammatory bowel disease (IBD).AIM: To assess whether immunogenicity to a patient's first anti-TNF agent would be associated with immunogenicity to the second, irrespective of drug sequence METHODS: We conducted a UK-wide, multicentre, retrospective cohort study to report rates of immunogenicity and treatment failure of second anti-TNF therapies in 1058 patients with IBD who underwent therapeutic drug monitoring for both infliximab and adalimumab. The primary outcome was immunogenicity to the second anti-TNF agent, defined at any timepoint as an anti-TNF antibody concentration ≥9 AU/ml for infliximab and ≥6 AU/ml for adalimumab.RESULTS: In patients treated with infliximab and then adalimumab, those who developed antibodies to infliximab were more likely to develop antibodies to adalimumab, than patients who did not develop antibodies to infliximab (OR 1.99, 95%CI 1.27-3.20, p = 0.002). Similarly, in patients treated with adalimumab and then infliximab, immunogenicity to adalimumab was associated with subsequent immunogenicity to infliximab (OR 2.63, 95%CI 1.46-4.80, p < 0.001). For each 10-fold increase in anti-infliximab and anti-adalimumab antibody concentration, the odds of subsequently developing antibodies to adalimumab and infliximab increased by 1.73 (95% CI 1.38-2.17, p < 0.001) and 1.99 (95%CI 1.34-2.99, p < 0.001), respectively. Patients who developed immunogenicity with undetectable drug levels to infliximab were more likely to develop immunogenicity with undetectable drug levels to adalimumab (OR 2.37, 95% CI 1.39-4.19, p < 0.001). Commencing an immunomodulator at the time of switching to the second anti-TNF was associated with improved drug persistence in patients with immunogenic, but not pharmacodynamic failure.CONCLUSION: Irrespective of drug sequence, immunogenicity to the first anti-TNF agent was associated with immunogenicity to the second, which was mitigated by the introduction of an immunomodulator in patients with immunogenic, but not pharmacodynamic treatment failure

Electrical Machine Topologies: Hottest Topics in the Electrical Machine Research Community

n this article, the state of the art in electrical machine design is outlined underlining the problems and challenges to be solved by engineers. As highlighted in this article, even if electrical machine design is often considered a mature issue from the technical and technological point of view, every year, new progresses and steps forward are made. New and more sophisticated design tools can be used worldwide, and innovative manufacturing processes, new insulation materials, and higher performance magnetic materials are available on the market. In addition, the evolution of the hardware used in digital control and new powerful power electronic devices represents a constant stimulus to improve the performance of electrical machines and reintroduce electrical machine structures that were not adopted in the past due to technological and technical constraints. As shown in this article, electrical machine design is an evergreen topic, and its importance is rising more each year under the push of more energy-saving requirements and higher-efficiency systems for electromechanical conversion. A green world will not be possible without electrical machines

Electrical machine topologies: hottest topics in the electrical machine research community

n this article, the state of the art in electrical machine design is outlined underlining the problems and challenges to be solved by engineers. As highlighted in this article, even if electrical machine design is often considered a mature issue from the technical and technological point of view, every year, new progresses and steps forward are made. New and more sophisticated design tools can be used worldwide, and innovative manufacturing processes, new insulation materials, and higher performance magnetic materials are available on the market. In addition, the evolution of the hardware used in digital control and new powerful power electronic devices represents a constant stimulus to improve the performance of electrical machines and reintroduce electrical machine structures that were not adopted in the past due to technological and technical constraints. As shown in this article, electrical machine design is an evergreen topic, and its importance is rising more each year under the push of more energy-saving requirements and higher-efficiency systems for electromechanical conversion. A green world will not be possible without electrical machines