Robust methods for outlier detection and regression for SHM applications.

In this paper, robust statistical methods are presented for the data-based approach to structural health monitoring (SHM). The discussion initially focuses on the high level removal of the ‘masking effect’ of inclusive outliers. Multiple outliers commonly occur when novelty detection in the form of unsupervised learning is utilised as a means of damage diagnosis; then benign variations in the operating or environmental conditions of the structure must be handled very carefully, as it is possible that they can lead to false alarms. It is shown that recent developments in the field of robust regression can provide a means of exploring and visualising SHM data as a tool for exploring the different characteristics of outliers, and removing the effects of benign variations. The paper is not, in any sense, a survey; it is an overview and summary of recent work by the authors

A report on the 6th European Conference on Structural Control

A short report is provided on the 6th European Conference on Structural Control which took place in Sheffield from 11–13 July 201

The use of pseudo-faults for damage location in SHM: An experimental investigation on a Piper Tomahawk aircraft wing

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.The application of pattern recognition-based approaches in damage localisation and quantification will eventually require the use of some kind of supervised learning algorithm. The use, and most importantly, the success of such algorithms will depend critically on the availability of data from all possible damage states for training. It is perhaps well known that the availability of damage data through destructive means cannot generally be afforded in the case of high value engineering structures outside laboratory conditions. This paper presents the attempt to use added masses in order to identify features suitable for training supervised learning algorithms and then to test the trained classifiers with damage data, with the ultimate purpose of damage localisation. In order to test the approach of adding masses, two separate cases of a dual-class classification problem, representing two distinct locations, and a three-class problem representing three distinct locations, are examined with the help of a full-scale aircraft wing. It was found that an excellent rate of correct classification could be achieved in both the dual-class and three-class cases. However, it was also found that the rate of correct classification was sensitive to the choices made in training the supervised learning algorithm. The results for the dual-class problem demonstrated a comparatively high level of robustness to these choices with a substantially lower robustness found in the three-class case

On evolutionary system identification with applications to nonlinear benchmarks

This paper presents a record of the participation of the authors in a workshop on nonlinear system identification held in 2016. It provides a summary of a keynote lecture by one of the authors and also gives an account of how the authors developed identification strategies and methods for a number of benchmark nonlinear systems presented as challenges, before and during the workshop. It is argued here that more general frameworks are now emerging for nonlinear system identification, which are capable of addressing substantial ranges of problems. One of these frameworks is based on evolutionary optimisation (EO); it is a framework developed by the authors in previous papers and extended here. As one might expect from the ‘no-free-lunch’ theorem for optimisation, the methodology is not particularly sensitive to the particular (EO) algorithm used, and a number of different variants are presented in this paper, some used for the first time in system identification problems, which show equal capability. In fact, the EO approach advocated in this paper succeeded in finding the best solutions to two of the three benchmark problems which motivated the workshop. The paper provides considerable discussion on the approaches used and makes a number of suggestions regarding best practice; one of the major new opportunities identified here concerns the application of grey-box models which combine the insight of any prior physical-law based models (white box) with the power of machine learners with universal approximation properties (black box)

Experimental evaluation of environmental effects on a polymer-coated aluminium structure: a time-series analysis and pattern recognition approach

Temperature variation is an important issue that needs to be considered when trying to develop a reliable Structural Health Monitoring (SHM) strategy. In the case that a data-based approach is chosen for damage detection, environmental fluctuations could be erroneously regarded as an abnormal condition of the structure and could mask the presence of damage. One of the objectives of the current work is to examine a statistical pattern recognition approach for novelty detection under different temperature conditions. A second important issue that could hinder the reliability of a SHM strategy is any kind of nonlinear behaviour, not associated with damage, in a system. For the purposes of this paper, the dynamic behaviour of a polymer-coated aluminium structure with ribs fixed with bolts is examined. The autoregressive parameters are the damage sensitive features and later, it is performed Principal Component Analysis (PCA) for robust novelty detection that takes into account the temperature variation

Organizational cultures: Obstacles to women in the UK construction industry

The global economic downturn coupled with recent changes in UK law have led to a sizable reduction in public sector funding. As a result, both public and private sector organizations are under greater pressure to provide evidence of their activities in promoting equality and diversity in their use of public sector funds. This requirement poses a particular challenge for the UK construction industry, which remains largely White male dominated. Empirical data gathered from a series of semistructured questionnaires and focus groups that have received managerial and soft skills training are analyzed and discussed in this article in an effort to establish the organizational cultural obstacles that women face in working in the UK construction industry. The findings outline that White male-dominated organizational cultures, inflexible work practices, and a lack of supportive networks serve as obstacles to women in the UK construction industry. This study concludes with recommendations for the expansion of training opportunities for women to encourage workforce diversity within the UK construction industry

On Model- and Data-based Approaches to Structural Health Monitoring

Structural Heath Monitoring (SHM) is the term applied to the process of periodically monitoring the state of a structural system with the aim of diagnosing damage in the structure. Over the course of the past several decades there has been ongoing interest in approaches to the problem of SHM. This attention has been sustained by the belief that SHM will allow substantial economic and life-safety benefits to be realised across a wide range of applications. Several numerical and laboratory implementations have been successfully demonstrated. However, despite this research effort, real-world applications of SHM as originally envisaged are somewhat rare. Numerous technical barriers to the broader application of SHM methods have been identified, namely: severe restrictions on the availability of damaged-state data in real-world scenarios; difficulties associated with the numerical modelling of physical systems; and limited understanding of the physical effect of system inputs (including environmental and operational loads). This thesis focuses on the roles of law-based and data-based modelling in current applications of. First, established approaches to model-based SHM are introduced, with the aid of an exemplar ‘wingbox’ structure. The study highlights the degree of difficulty associated with applying model-updating-based methods and with producing numerical models capable of accurately predicting changes in structural response due to damage. These difficulties motivate the investigation of non-deterministic, predictive modelling of structural responses taking into account both experimental and modelling uncertainties. Secondly, a data-based approach to multiple-site damage location is introduced, which may allow the quantity of experimental data required for classifier training to be drastically reduced. A conclusion of the above research is the identification of hybrid approaches, in which a forward-mode law-based model informs a data-based damage identification scheme, as an area for future wor

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma.

Ewing's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease. Ewing's sarcoma cells are acutely hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibition and this is being evaluated in clinical trials, although the mechanism of hypersensitivity has not been directly addressed. PARP inhibitors have efficacy in tumors with BRCA1/2 mutations, which confer deficiency in DNA double-strand break (DSB) repair by homologous recombination (HR). This drives dependence on PARP1/2 due to their function in DNA single-strand break (SSB) repair. PARP inhibitors are also cytotoxic through inhibiting PARP1/2 auto-PARylation, blocking PARP1/2 release from substrate DNA. Here, we show that PARP inhibitor sensitivity in Ewing's sarcoma cells is not through an apparent defect in DNA repair by HR, but through hypersensitivity to trapped PARP1-DNA complexes. This drives accumulation of DNA damage during replication, ultimately leading to apoptosis. We also show that the activity of PARP inhibitors is potentiated by temozolomide in Ewing's sarcoma cells and is associated with enhanced trapping of PARP1-DNA complexes. Furthermore, through mining of large-scale drug sensitivity datasets, we identify a subset of glioma, neuroblastoma and melanoma cell lines as hypersensitive to the combination of temozolomide and PARP inhibition, potentially identifying new avenues for therapeutic intervention. These data provide insights into the anti-cancer activity of PARP inhibitors with implications for the design of treatment for Ewing's sarcoma patients with PARP inhibitors.Research in the M.J.G. laboratory is supported by grants from the Wellcome Trust (086357 and 102696/Z/13/Z; http://www.wellcome.ac.uk/Funding). Research in the S.P.J. laboratory is funded by Cancer Research UK Program Grant C6/A11224 (http://www.cancerresearchuk.org/funding-for-researchers/our-funding-schemes), the European Research Council (http://erc.europa.eu/funding-and-grants)and the European Community Seventh Framework Program grant agreement no. HEALTH-F2-2010-259893 (DDResponse). Core infrastructure funding was provided by Cancer Research UK Grant C6946/A14492 and Wellcome Trust Grant WT092096. S.P.J. receives a salary from the University of Cambridge, supplemented by Cancer Research UK. J.T. was funded by the European Community Seventh Framework Program grant agreement no. HEALTH-F2-2010-259893 (DDResponse). U.M. is supported by a Cancer Research UK Clinician Scientist Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pone.014098