The Era of Tadeusz Pawlikowski and Irish Theatre

Tadeusz Pawlikowski was arguably Poland’s greatest theatre director of the fin de siècle. With stints as Theatre Manager in both Kraków and Lwów municipal theatres, Pawlikowski excelled in developing ensemble casts and cultivating audiences without kowtowing to popular tastes. He was also responsible for bringing many western plays to partitioned Poland, and indeed he oversaw theatrical premieres of Oscar Wilde, George Bernard Shaw and John Millington Synge. This paper will look at the production and reception of these plays and will record how there was a growing conviction amongst Polish critics that Irish dramatists would soon make a towering impact on the age. That said, not all the productions were as successful as perhaps they should have been. When in Lwów, Pawlikowski attempted to flood the city with drama and this ambition entailed brief run-throughs and the shortening of texts in order to facilitate the learning of lines. Needless to say, there was little time for work on characterization. Consequently, it was often pointed out that performances had failed to bridge the cultural gap where a foreign piece was concerned. To this end, this paper will assess both the contribution of Tadeusz Pawlikowski to Irish theatre, and the reception and legacy of the productions which took place under his directorial guidance

From High Hopes of the Celtic Twilight to Last Hurrahs in Inter-war Warsaw: The Plays of Casimir Dunin-Markievicz

Recent reassessments have done much to show that Casimir Markievicz’s cultural activism in Ireland made unique contributions to its renascent cultural nationalism: his portraiture recorded key moments and personages of the age; whereas his role as a dramatist and theatrical impresario in thrall to Shaw, theatrical naturalism and social engagement represented a supplementation of the Celtic Literary Revival. As a further contribution to what is a growing awareness of the importance of Markievicz as a historical, artistic and literary figure, this article will seek to show that, following the breakdown of his marriage and his return to Poland in 1913, Markievicz would also play a meaningful if short-lived role in the emerging modernity of Warsaw’s post-war theatrical world. It will also look to assess why his career foundered, with consequences for his own literary legacy here in Poland

Evaluating the Impact of Uveitis on Visual Field Progression Using Large Scale Real-World Data

PURPOSE: To compare rates of visual field (VF) loss in uveitis patients with glaucoma against patients with primary open angle glaucoma (POAG) and explores the association between intraocular pressures (IOP) and rate of VF loss. Design; Retrospective cohort study. METHODS: Anonymized VFs and IOP measurements extracted from the EMR of 5 regionally different glaucoma clinics in England. A total of 205 eyes with diagnosis of "uveitis" plus "glaucoma" were compared with 4600 eyes with "POAG" only. Minimum inclusion criteria was ≥4 visits within a 4-year window. Relative risk (RR) of being a "rapid progressor" (mean deviation (MD) loss ≥1.5 dB/year) was calculated. A mixed-effects model (MEM) and a pointwise VF progression analysis of pattern deviation was used to confirm differences between the groups. Longitudinal IOP mean, range and variability were compared with rate of VF progression. RESULTS: Median (IQR) baseline MD in the uveitis and POAG groups was -3.8 (-8.7, -1.5) dB and -3.1 (-6.6, -1.2) dB respectively. The uveitis and POAG groups had 23/205 (11%) and 331/4600 (7%) "rapidly progressing" eyes respectively. Age-adjusted RR for "rapid progression" in uveitic versus POAG eyes was 1.9 (95% CI:1.8-2.0). The MEM confirmed that uveitic eyes (-0.49 dB/year) showed higher rates of VF progression than the POAG group (-0.37 dB/year; p<0.01). IOP range and variability were higher in the "rapidly progressing" uveitic eyes. CONCLUSIONS: Our analysis suggests that VF loss occurs faster in glaucoma patients with uveitis than those without uveitis. The risk of progressing rapidly in glaucoma with uveitis is almost double than in those without uveitis. Early identification of "rapid progressors" may enable targeted intervention to preserve visual function in this high-risk group

Retrieval, reuse, revision and retention in case-based reasoning

El original está disponible en www.journals.cambridge.orgCase-based reasoning (CBR) is an approach to problem solving that emphasizes the role of prior experience during future problem solving (i.e., new problems are solved by reusing and if necessary adapting the solutions to similar problems that were solved in the past). It has enjoyed considerable success in a wide variety of problem solving tasks and domains. Following a brief overview of the traditional problem-solving cycle in CBR, we examine the cognitive science foundations of CBR and its relationship to analogical reasoning. We then review a representative selection of CBR research in the past few decades on aspects of retrieval, reuse, revision, and retention.Peer reviewe

Epidemiological findings and medical, legal, and public health challenges of an investigation of severe soft tissue infections and deaths among injecting drug users: Ireland, 2000.

In May 2000, public health authorities in Dublin, Ireland, identified a cluster of unexplained severe illness among injecting drug users (IDUs). Similar clusters were also reported in Scotland and England. Concurrent investigations were undertaken to identify the aetiology and source of the illnesses. In Dublin, 22 IDUs were identified with injection-site inflammation resulting in hospitalization or death; eight (36%) died. Common clinical findings among patients with severe systemic symptoms included leukaemoid reaction and cardiogenic shock. Seventeen (77%) patients reported injecting heroin intramuscularly in the 2 weeks before illness. Of 11 patients with adequate specimens available for testing, two (18%) were positive by 16S rDNA PCR for Clostridium novyi. Clinical and laboratory findings suggested that histotoxic Clostridia caused a subset of infections in these related clusters. Empiric treatment for infections among IDUs was optimized for anaerobic organisms, and outreach led to increased enrolment in methadone treatment in Dublin. Many unique legal, medical, and public health challenges were encountered during the investigation of this outbreak

Making embedded knowledge transparent: How the V-Dem dataset opens new vistas in civil society research

We show how the V-Dem data opens new possibilities for studying civil society in comparative politics. We explain how V-Dem was able to extract embedded expert knowledge to create a novel set of civil society indicators for 173 countries from 1900 to the present. This data overcomes shortcomings in the basis on which inference has been made about civil society in the past by avoiding problems of sample bias that make generalization difficult or tentative. We begin with a discussion of the reemergence of civil society as a central concept in comparative politics. We then turn to the shortcomings of the existing data and discusses how the V-Dem data can overcome them. We introduce the new data, highlighting two new indices—the core civil society index (CCSI) and the civil society participation index (CSPI)—and explain how the individual indicators and the indices were created. We then demonstrate how the CCSI uses embedded expert knowledge to capture the development of civil society on the national level in Venezuela, Ghana, and Russia. We close by using the new indices to examine the dispute over whether post-communist civil society is “weak.” Time-series cross-sectional analysis using 2,999 country-year observations between 1989 and 2012 fails to find that post-communist civil society is substantially different from other regions, but that there are major differences between the post-Soviet subsample and other post-communist countries both in relation to other regions and each other

Birdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment

Birdshot chorioretinopathy (BCR) is a rare form of chronic, bilateral, posterior uveitis with a distinctive clinical phenotype, and a strong association with HLA-A29. It predominantly affects people in middle age. Given its rarity, patients often encounter delays in diagnosis leading to delays in adequate treatment, and thus risking significant visual loss. Recent advances have helped increase our understanding of the underlying autoimmune mechanisms involved in disease pathogenesis, and new diagnostic approaches such as multimodality imaging have improved our ability to both diagnose and monitor disease activity. Whilst traditional immunosuppressants may be effective in BCR, increased understanding of immune pathways is enabling development of newer treatment modalities, offering the potential for targeted modulation of immune mediators. In this review, we will discuss current understanding of BCR and explore recent developments in diagnosis, monitoring and treatment of this disease. Synonyms for BCR: Birdshot chorioretinopathy, Birdshot retinochoroiditis, Birdshot retino-choroidopathy, Vitiliginous choroiditis. Orphanet number: ORPHA179 OMIM: 605808