Generalised Einstein mass-variation formulae: II Superluminal relative frame velocities

AbstractIn part I of this paper we have deduced generalised Einstein mass variation formulae assuming relative frame velocities v<c. Here we present corresponding new expressions for superluminal relative frame velocities v>c. We again use the notion of the residual mass m0(v) which for v>c is defined by the equation m(v)=m0(v)[(v/c)2-1]-1/2 for the actual mass m(v). The residual mass is essentially the actual mass with the Einstein factor removed, and we emphasise that we make no restrictions on m0(v). Using this formal device we deduce corresponding new mass variation formulae applicable to superluminal relative frame velocities, assuming only the extended Lorentz transformations and their consequences, and two invariants that are known to apply in special relativity. The present authors have previously speculated a dual framework such that both the rest mass m0∗ and the residual mass at infinite velocity m∞∗ (by which we mean p∞∗/c, assuming finite momentum at infinity) are equally important parameters in the specification of mass as a function of its velocity, and the two arbitrary constants can be so determined. The new formulae involving two arbitrary constants may also be exploited so that the mass remains finite at the speed of light, and two distinct mass profiles are determined as functions of their velocity with the rest mass assumed to be alternatively prescribed at the origin of either frame. The two profiles so obtained (M(U),m(u)) and (M∗(U),m∗(u)) although distinct have a common ratio M(U)/M∗(U)=m(u)/m∗(u) that is a function of v>c, indicating that observable mass depends upon the frame in which the rest mass is prescribed

Persistent Offenders in the North West of England, 1880-1940: Some Critical Research Questions

This article examines the concept of the persistent offender as a group within society, and the presumed impact of that discrete group upon society via a case study of offending in Crewe between 1880 and 1940. The findings of persistent offending in Crewe challenge the assumptions and prejudices of the period, about the links between unemployment and crime and the extent to which crime was an enduring ‘career’. There were no ‘hardened’ persistent offenders in the sample of the type envisaged by contemporary comment, though the role of drink in offending was sustained; and there was no clear ‘type’ of offender either. Examination of the life histories of a selection of offenders is shown to raise a number of interdisciplinary questions, challenging the assumptions of criminologists and legal scholars in relation to the role of legislation in the management of criminality, including the concept (of interest also to historians) that reformation of the criminal was more achievable in the past than it is in the overregulated present

Zvjezdača Tethyaster subinermis (Philippi, 1837) (Asteroidea; Astropectinidae): Nova vrsta u fauni britanskih bodljikaša

The starfish Tethyaster subinermis is documented from the south-western parts of British waters, with one specimen caught by trawl at 48° 27.5’N, 009° 35.3’W (208–250 m depth) in 2001 and a further two specimens caught by trawl at 48° 28.32’N, 009° 33.23’W (189–217 m depth) in 2020.Autori iznose novi nalaz morske zvijezdače Tethyaster subinermis iz jugozapadnih dijelova britanskih voda, s jednim primjerkom ulovljenim koćom na 48 ° 27,5 ‘N, 009 ° 35,3’ W (dubine 208–250 m) 2001. godine i dva primjerka koja su ulovljena povlačnom mrežom na 48 ° 28,32’N, 009 ° 33,23’W (dubina 189–217 m) u 2020. godini

Continuum modelling of gigahertz nano-oscillators

Fullerenes and carbon nanotubes are of considerable interest throughout many scientific areas due to their unique and exceptional properties, such as low weight, high strength, flexibility, high thermal conductivity and chemical stability. These nanostructures have many potential applications in nano-devices. One concept that has attracted much attention is the creation of nano-oscillators, which can produce frequencies in the gigahertz range, for applications such as ultra-fast optical filters and nano-antennae. In this paper, we provide the underlying mechanisms of the gigahertz nano-oscillators and we review some recent results derived by the authors using the Lennard-Jones potential together with the continuum approach to mathematically model three different types of nano-oscillators including double-walled carbon nanotube, C60-nanotube and C60-nanotorus oscillators

Policing the industrial north of England 1777-1877: the control of labour at work, and in the streets

Amongst the considerable and valuable canon of work on the introduction of public uniformed police services in the nineteenth-century, there has been a robust strand of research on privately-funded agencies of control. Whilst research on publicly-funded bodies has largely focused on order-maintenance and preventative crime-control; others have studied the protection that private policing agencies offered to sectional interests. This article seeks to make some connections between the activities of one particular private agency – the Worsted Committee and their Inspectorate – and the development of public policing in the West Riding of Yorkshire in the industrial north of England. In particular the article questions: how did a private agency designed to regulate private space and a public body (Bradford Borough Police) that was supposed to protect public order in public spaces find a working partnership in the mid- to late-nineteenth century; how successful was this unofficial arrangement; and what were the consequences that flowed from this notional partnership for the development of policing in the West Riding, and the control of labour in the workplace and in the streets

Tolerance Induction to Cytoplasmic β\beta-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

Background: Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequate levels of transgene expression in hepatocytes induce a suppressive T cell response, thereby promoting immune tolerance. This study addresses the question of whether AAV gene transfer can induce tolerance to a cytoplasmic protein. Major Findings: AAV-2 vector-mediated hepatic gene transfer for expression of cytoplasmic $\beta$-galactosidase ($\beta$-gal) was performed in immune competent mice, followed by a secondary $\beta$-gal gene transfer with E1/E3-deleted adenoviral Ad-LacZ vector to provoke a severe immunotoxic response. Transgene expression from the AAV-2 vector in $\sim$2% of hepatocytes almost completely protected from inflammatory T cell responses against $\beta$-gal, eliminated antibody formation, and significantly reduced adenovirus-induced hepatotoxicity. Consequently, $\sim$10% of hepatocytes continued to express $\beta$-gal 45 days after secondary Ad-LacZ gene transfer, a time point when control mice had lost all Ad-LacZ derived expression. Suppression of inflammatory T cell infiltration in the liver and liver damage was linked to specific transgene expression and was not seen for secondary gene transfer with Ad-GFP. A combination of adoptive transfer studies and flow cytometric analyses demonstrated induction of Treg that actively suppressed CD8$^+$ T cell responses to $\beta$-gal and that was amplified in liver and spleen upon secondary Ad-LacZ gene transfer. Conclusions: These data demonstrate that tolerance induction by hepatic AAV gene transfer does not require systemic delivery of the transgene product and that expression of a cytoplasmic neo-antigen in few hepatocytes can induce Treg and provide long-term suppression of inflammatory responses and immunotoxicity

PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome

Hematopoietic growth factors (HGF) are recommended therapy for high dose radiation exposure, but unfavorable administration schedules requiring early and repeat dosing limit the logistical ease with which they can be used. In this report, using a previously described murine model of H-ARS, survival efficacy and effect on hematopoietic recovery of unique PEGylated HGF were investigated. The PEGylated-HGFs possess longer half-lives and more potent hematopoietic properties than corresponding non-PEGylated-HGFs. C57BL/6 mice underwent single dose lethal irradiation (7.76-8.72 Gy, Cs, 0.62-1.02 Gy min) and were treated with various dosing regimens of 0.1, 0.3, and 1.0 mg kg of analogs of human PEG-G-CSF, murine PEG-GM-CSF, or human PEG-IL-11. Mice were administered one of the HGF analogs at 24-28 h post irradiation, and in some studies, additional doses given every other day (beginning with the 24-28 h dose) for a total of three or nine doses. Thirty-day (30 d) survival was significantly increased with only one dose of 0.3 mg kg of PEG-G-CSF and PEG-IL-11 or three doses of 0.3 mg kg of PEG-GM-CSF (p ≤ 0.006). Enhanced survival correlated with consistently and significantly enhanced WBC, NE, RBC, and PLT recovery for PEG-G- and PEG-GM-CSF, and enhanced RBC and PLT recovery for PEG-IL-11 (p ≤ 0.05). Longer administration schedules or higher doses did not provide a significant additional survival benefit over the shorter, lower dose, schedules. These data demonstrate the efficacy of BBT's PEG-HGF to provide significantly increased survival with fewer injections and lower drug doses, which may have significant economic and logistical value in the aftermath of a radiation event

Формування законодавчої і нормативної бази архівної справи в республіці Казахстан

Аналізується законодавство Республіки Казахстан, спрямоване на забезпечення збереження документальної спадщини, регулювання діяльності архівної системи в умовах державного суверенітету. Визначаються особливості архівного законодавства кінця 1990-х рр., прослідковуються його зміни та напрями удосконалення в 2000-х рр., процеси формування нормативної бази архівної справи.Анализируется законодательство Республики Казахстан, направленное на обеспечение сохранности документального наследия, регулирование деятельности архивной системы в условиях государственного суверенитета. Определяются особенности архивного законодательства конца 1990-х гг., прослеживаются его изменения и направления усовершенствования в 2000- х гг., процессы формирования нормативной базы архивного дела.The legislation of Republic of Kazakhstan, directed on providing of safety of documentary legacy, adjusting of activity of the archival system in the conditions of the state sovereignty is analysed in the article. The features of the archival legislation the end of 1990-th are determined, its changes and directions of improvement in the 2000-th, the processes of forming of normative base of the archival affairs are traced