Venta de hijos : novela española

Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration.

The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation. Dmrt1 plays a similar role in postnatal testes, but the mechanism of adult testis maintenance remains mostly unknown. Sox9 and Sox8 are required for postnatal male fertility, but their role in the adult testis has not been investigated. Here we show that after ablation of Sox9 in Sertoli cells of adult, fertile Sox8(-/-) mice, testis-to-ovary genetic reprogramming occurs and Sertoli cells transdifferentiate into granulosa-like cells. The process of testis regression culminates in complete degeneration of the seminiferous tubules, which become acellular, empty spaces among the extant Leydig cells. DMRT1 protein only remains in non-mutant cells, showing that SOX9/8 maintain Dmrt1 expression in the adult testis. Also, Sox9/8 warrant testis integrity by controlling the expression of structural proteins and protecting Sertoli cells from early apoptosis. Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 and coordinately with Dmrt1, also controls adult testis maintenance

Value-based healthcare in Catalonia: challenges and opportunities to contribute to the future

Atenció sanitària basada en el valor; Serveis de salut; Nous models assistencialsAtención sanitaria basada en el valor; Servicios de salud; Nuevos modelos asistencialesValue-based Healthcare; Health services; New healthcare modelsL'atenció sanitària basada en el valor -en anglès Value-Based Healthcare (VBHC)- representa un nou paradigma en la provisió de serveis de salut. L'AQuAS publica aquest treball de reflexió on s'explora la definició d'aquest nou paradigma i es proposa un nou model que permeti incrementar el valor de l'atenció sanitària al sistema de salut de CatalunyaThe health care based on the value -in English Value-Based Healthcare (VBHC) - represents a new paradigm in the provision of health services. Published work explores reflection on the definition of this new paradigm and proposes a new model that would increase the value of health care in the health system of Catalonia.La atención sanitaria basada en el valor -en inglés Value-Based Healthcare (VBHC) - representa un nuevo paradigma en la provisión de servicios de salud. El AQuAS publica este trabajo de reflexión donde se explora la definición de este nuevo paradigma y se propone un nuevo modelo que permita incrementar el valor de la atención sanitaria en el sistema de salud de Cataluña

Paca Cielos : (los humildes) : novela española

Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

Situación actual de Dictamnus hispanicus Webb (Rutaceae) en la provincia de Alicante: distribución y aspectos etnobotánicos

Spanish Burning bush (Dictamnus hispanicus), is a endemic species of the Eastern half of the Iberian peninsula, which has outstanding relevance in the province of Alicante (Valencian Community, Spain) due to its traditional use, as a component of the ?herberos? ? herbal spirit drinks?. However, there is still little information on other uses of the species in the same province. In order to increase this knowledge, semi-structured interviews (n=90) have been made, and information on its distribution range has been completed using Geographic Information Systems; the species has been rederred to 27 1×1 km UTM squares. 5 phytonyms in Valencian language (74.44% of the informants) and 6 in Castilian or Spanish (25.66%) have been collected. 9 applications uses have been identified: liqueurs (spirits), menstruation regulation, respiratory diseases relieve, intestinal inflammations, alleviation of hard digestion, aerophagia, bad breath, abortion, flavouring cabinets and prevention against the proliferation of moths

Influencia de algunos fármacos tranquilizantes sobre el aprovechamiento nutritivo de proteínas y grasas en la rata

Se estudia en ratas el aprovechamiento nutritivo de la proteína y grasa, bajo la influencia de agentes tranquilizantes (Diazepan y Perfenacina) adicionados a la dieta a dos niveles (1,5 mg/100 g de dieta y 3 mg/100 g de dieta) encontrando los siguientes resultados. 1) La dieta adicionada de la dosis mínÍma de Diazepan no modifica la ingesta, cambios ponderales, eficacia digestiva ni metabólica del nitrógeno, tanto en hembras como en machos. A dosis superiores el Diazepan tampoco modifica de una manera patente ninguno de los parámetros anteriormente citados, si bien tienden a ser mayores. 2) La eficacia digestiva de la grasa no se modifica por el efecto del Diazepan adicionado a la dosis mínima; sin embargo, la dosis de 3 mg/100 g de dieta disminuye el coeficiente de digestibilidad lipídico, descenso que es mucho más patente en hembras que en machos. 3) La Perfenacina disminuye la in gesta de alimentos, sobre todo en machos, y a la dosis máxima. No obstante, la eficacia digestiva del nitrógeno, no se modifica. Tampoco afecta la retención de nitrógeno a nivel metabólico en hembras, en tanto que en los machos de lugar a una importante reducción. El fármaco no modifica la eficacia digestiva de la grasa.Nutritive utilization of protein and fat in rats under tratment with tranquilizer agents (Diazepan and Perfenacine) added to diet at two levels 0,5 mg/lOO g and 3 mg/lOO g of diet) was studied. 1) Diet with lowest doses of Diazepan does not modify intake, pon deral changes, digestive or metabolic efficacy of nitrog- en, either in males or in females. Similarly highest doses of Diazepan do not clearly modify none of those parameters, although aH of them showed a mild increase. 2) Digestive efficacy of fat do es not change because of lowest doses of Diazepan, however doses of 3 mg/lOO g of diet do diminish lipidic digestibility coefficient, decrease that is much biger in females than in males. 3) Perfenacine, at higest doses decreases food intake above aH in males. Nevertheles digestive efficacy of nitro gen was not modify, neither nitro gen retention at metabolic levels in females, however in males it was detected a clear reduction in this parameter. This drug do es not modify digestive efficacy of fat

Misericordia : novela española

Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

Amapola : (novela andaluza)

Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201