Reassessment of the evidence for postcranial skeletal pneumaticity in Triassic archosaurs, and the early evolution of the avian respiratory system.

Uniquely among extant vertebrates, birds possess complex respiratory systems characterised by the combination of small, rigid lungs, extensive pulmonary air sacs that possess diverticula that invade (pneumatise) the postcranial skeleton, unidirectional ventilation of the lungs, and efficient crosscurrent gas exchange. Crocodilians, the only other living archosaurs, also possess unidirectional lung ventilation, but lack true air sacs and postcranial skeletal pneumaticity (PSP). PSP can be used to infer the presence of avian-like pulmonary air sacs in several extinct archosaur clades (non-avian theropod dinosaurs, sauropod dinosaurs and pterosaurs). However, the evolution of respiratory systems in other archosaurs, especially in the lineage leading to crocodilians, is poorly documented. Here, we use µCT-scanning to investigate the vertebral anatomy of Triassic archosaur taxa, from both the avian and crocodilian lineages as well as non-archosaurian diapsid outgroups. Our results confirm previous suggestions that unambiguous evidence of PSP (presence of internal pneumatic cavities linked to the exterior by foramina) is found only in bird-line (ornithodiran) archosaurs. We propose that pulmonary air sacs were present in the common ancestor of Ornithodira and may have been subsequently lost or reduced in some members of the clade (notably in ornithischian dinosaurs). The development of these avian-like respiratory features might have been linked to inferred increases in activity levels among ornithodirans. By contrast, no crocodile-line archosaur (pseudosuchian) exhibits evidence for unambiguous PSP, but many of these taxa possess the complex array of vertebral laminae and fossae that always accompany the presence of air sacs in ornithodirans. These laminae and fossae are likely homologous with those in ornithodirans, which suggests the need for further investigation of the hypothesis that a reduced, or non-invasive, system of pulmonary air sacs may be have been present in these taxa (and secondarily lost in extant crocodilians) and was potentially primitive for Archosauria as a whole

New information on the palate and lower jaw of Massospondylus (Dinosauria: Sauropodomorpha)

Additional anatomical details of the palate and lower jaw of the prosauropod dinosaur Massospondylus Owen are documented on the basis of a previously undescribed skull from the upper Elliot Formation. The palate is generally similar to that of other early sauropodomorphs, but can be shown to differ from those of Plateosaurus, Lufengosaurus and Thecodontosaurus in several respects. For example, Massospondylus lacks the well-developed palatine boss seen in Plateosaurus and the pneumatic recess that is present on the ectopterygoid of Thecodontosaurus. In addition, Massospondylus possesses an expanded medioventral premaxillary process that is much larger than that of any other basal sauropodomorph.The Royal Society of London and the Palaeontological Research Fund of the Natural History Museu

A revision of the non-avian dinosaurs ‘Eucercosaurus tanyspondylus’ and ‘Syngonosaurus macrocercus’ from the Cambridge Greensand, UK

The Cambridge Greensand Member (lower Cenomanian: Upper Cretaceous) has yielded a diverse fauna of terrestrial and marine tetrapods, whose remains are largely reworked from the underlying Gault Formation (upper Albian: Lower Cretaceous). Here, we re-describe two of the non-avian dinosaur taxa named from this unit, ‘Eucercosaurus tanyspondylus’ Seeley, 1879 and ‘Syngonosaurus macrocercus’ Seeley, 1879, both of which have been referred to as either ankylosaurs or ornithopods but whose validity has not been rigorously assessed for over a century. Both taxa are interpreted as the remains of iguanodontian dinosaurs but possess no clear diagnostic features. Nevertheless, although ‘Eucercosaurus’ and ‘Syngonosaurus’ are nomina dubia they do indicate that iguanodontians were common components of the Cambridge Greensand tetrapod fauna and, alongside ‘Trachodon cantabrigiensis’ Lydekker, 1888, represent an important datum for understanding iguanodontian distributions during the mid-Cretaceous

V3885 Sagittarius: a Comparison with a Range of Standard Model Accretion Disks

A $\widetilde{\chi}^2$ analysis of standard model accretion disk synthetic spectrum fits to combined $FUSE$ and STIS spectra of V3885 Sagittarius, on an absolute flux basis, selects a model that accurately represents the observed SED. Calculation of the synthetic spectrum requires the following system parameters. The cataclysmic variable secondary star period-mass relation calibrated by Knigge in 2007 sets the secondary component mass. A mean white dwarf (WD) mass from the same study, that is consistent with an observationally-determined mass ratio, sets the adopted WD mass of $0.7M_{\odot}$, and the WD radius follows from standard theoretical models. The adopted inclination, i=65{\arcdeg}, is a literature consensus, and is subsequently supported by $\widetilde{\chi}^2$ analysis. The mass transfer rate is the remaining parameter to set the accretion disk $T_{\rm eff}$ profile, and the $Hipparcos$ parallax constrains that parameter to $\dot{M}=5.0{\pm}2.0{\times}10^{-9} M_{\odot} {\rm yr}^{-1}$ by a comparison with observed spectra. The fit to the observed spectra adopts the contribution of a $57,000{\pm}5000$K WD. The model thus provides realistic constraints on $\dot{M}$ and $T_{\rm eff}$ for a large $\dot{M}$ system above the period gap.Comment: 41 pages, 7 figures, 9 tables. Astrophysical Journal (accepted

Numerical approximation of statistical solutions of scalar conservation laws

We propose efficient numerical algorithms for approximating statistical solutions of scalar conservation laws. The proposed algorithms combine finite volume spatio-temporal approximations with Monte Carlo and multi-level Monte Carlo discretizations of the probability space. Both sets of methods are proved to converge to the entropy statistical solution. We also prove that there is a considerable gain in efficiency resulting from the multi-level Monte Carlo method over the standard Monte Carlo method. Numerical experiments illustrating the ability of both methods to accurately compute multi-point statistical quantities of interest are also presented

Body mass estimates of an exceptionally complete Stegosaurus (Ornithischia: Thyreophora): comparing volumetric and linear bivariate mass estimation methods

© 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. The file attached is the published version of the article

Expresión de las moléculas del Complejo Mayor de Histocompatibilidad clase II y moléculas co-estimuladoras en carcinomas orales in vitro

El descubrimiento de que el epitelio escamoso estratificado que cubre la mucosa oral podia expresar moleculas del Complejo Mayor de Histocompatibilidad clase II en varias condiciones patologicas de tipo inflamatorio abrio la posibilidad de que los queratinocitos orales sean celulas inmunologicamente activas, las cuales pueden funcionar con .celulas presentadoras de antigenos'ñ. Para una efectiva activacion de los linfocitos T, las celulas presentadoras de antigenos requieren, ademas de la expresion de moleculas del Complejo Mayor de Histocompatibilidad clase II, senales co-estimuladoras. El proposito del presente estudio fue determinar la expresion de moleculas del Complejo Mayor de Histocompatibilidad clase II y las moleculas co-estimuladoras CD40, CD80 y CD86 en queratinocitos bucales normales y derivados de carcinomas de celulas escamosas. Usando citometria de flujo en queratinocitos cultivados de mucosa oral sana y siete lineas celulares derivadas de carcinomas orales, fue confirmado que los queratinocitos expresan moleculas del Complejo Mayor de Histocompatibilidad clase II despues de estimulacion con IFN'Á in vitro. Todas las lineas celulares expresaron constitutivamente CD40, por el contrario, CD80 y CD86 universalmente fueron negativos. La ausencia de estas ultimas moleculas pudiera ser la causa por la cual los carcinomas orales escapan de la vigilancia inmunologica y pueden crecer, invadir y hacer metastasis pese al sistema inmunologico.Recognition in the 1980Es that keratinocytes can express class II molecules of the Major Histocompatibility Complex (MHC) first raised the possibility that these cells might have an immunological function, and may even act as antigen presenting cells (APC). For effective T lymphocyte activation, APC require, in addition to MHC II, appropriate costimulatory signals. The aim of this study was to determine the expression of MHC class II and the co-stimulatory molecules CD40, CD80 and CD86 in keratinocytes derived from healthy oral mucosa and oral carcinomas. Using flow cytometry, it was confirmed that oral keratinocytes .switch on'ñ expression of MHC class II molecules after stimulation with IFN'Á in vitro. All keratinocyte lines expressed CD40 constitutively; by contrast, CD80 and CD86 were universally absent. Loss of CD80 and CD86 may be one means whereby tumours escape immunological surveillance.