Epidemiological and evolutionary consequences of life-history trade-offs in pathogens

Peer reviewe

Extreme & High Synchrotron Peaked Blazars at the limit of Fermi-LAT detectability: the γ\gamma-ray spectrum of 1BIGB sources

We present the 1-100 GeV spectral energy distribution for a population of 148 high-synchrotron-peaked blazars (HSPs) recently detected with Fermi-LAT as part of the First Brazil-ICRANet Gamma-ray Blazar catalogue (1BIGB). Most of the 1BIGB sources do not appear in previous Fermi-LAT catalogues and their gamma-ray spectral properties are presented here for the first time, representing a significant new extension of the gamma-ray blazar population. Since our sample was originally selected from an excess signal in the 0.3-500 GeV band, the sources stand out as promising TeV blazar candidates, potentially in reach of the forthcoming very-high-energy (VHE) gamma-ray observatory, CTA. The flux estimates presented here are derived considering PASS8 data, integrating over more than 9 years of Fermi-LAT observations. We also review the full broadband fit between 0.3-500 GeV presented in the original 1BIGB paper for all sources, updating the power-law parameters with currently available Fermi-LAT dataset. The importance of these sources in the context of VHE population studies with both current instruments and the future CTA is evaluated. To do so, we select a subsample of 1BIGB sources and extrapolate their gamma-ray SEDs to the highest energies, properly accounting for absorption due to the extragalactic background light. We compare those extrapolations to the published CTA sensitivity curves and estimate their detectability by CTA. Two notable sources from our sample, namely 1BIGB J224910.6-130002 and 1BIGB J194356.2+211821, are discussed in greater detail. All gamma-ray SEDs, which are shown here for the first time, are made publicly available via the Brazilian Science Data Center (BSDC) service, maintained at CBPF, in Rio de Janeiro.Comment: 13 pages, 6 figure

LATTES: a novel detector concept for a gamma-ray experiment in the Southern hemisphere

The Large Array Telescope for Tracking Energetic Sources (LATTES), is a novel concept for an array of hybrid EAS array detectors, composed of a Resistive Plate Counter array coupled to a Water Cherenkov Detector, planned to cover gamma rays from less than 100 GeV up to 100 TeVs. This experiment, to be installed at high altitude in South America, could cover the existing gap in sensitivity between satellite and ground arrays. The low energy threshold, large duty cycle and wide field of view of LATTES makes it a powerful tool to detect transient phenomena and perform long term observations of variable sources. Moreover, given its characteristics, it would be fully complementary to the planned Cherenkov Telescope Array (CTA) as it would be able to issue alerts. In this talk, a description of its main features and capabilities, as well as results on its expected performance, and sensitivity, will be presented.Comment: Proceedings of the 35th International Cosmic Ray Conference (ICRC2017), Busan, South Korea. Presented by R. Concei\c{c}\~{a}o. 8 pages; v2: correct affiliation + journal referenc

LATTES: A new gamma-ray detector concept for South America

Currently the detection of Very High Energy gamma-rays for astrophysics rely on the measurement of the Extensive Air Showers (EAS) either using Cherenkov detectors or EAS arrays with larger field of views but also larger energy thresholds. In this talk we present a novel hybrid detector concept for a EAS array with an improved sensitivity in the lower energies (~ 100 GeV). We discuss its main features, capabilities and present preliminary results on its expected perfomances and sensitivities.This wide field of view experiment is planned to be installed at high altitude in South America making it a complementary project to the planned Cherenkov telescope experiments and a powerful tool to trigger further observations of variable sources and to detect transients phenomena

Integrated slot-waveguide microresonator for biochemical sensing

A novel integrated biochemical sensor based on a slot-waveguide [1] microring resonator is demonstrated. The microresonator is fabricated on a Si3N4/SiO2 material platform [2] by using conventional microfabrication techniques, such as Si thermal oxidation, chemical vapour deposition, electron-beam lithography and reactive ion etching. The sensor consists of a 70-μm-radius ring resonator formed by a slot-waveguide [1] having a slot-width of 200 nm. The operation wavelength is 1.3 μm. The device is exposed to different water-ethanol solutions and its transmission spectrum is measured. A linear shift of the resonant wavelength with increasing ambient refractive index of 212 nm/refractive index units (RIU) is observed. This value is more than twice larger than those of strip-waveguide ring resonator biochemical sensors, indicating that higher analyte-probe light interaction occurs in our slot-waveguide sensor as compared to those based on conventional strip waveguides. The sensor detects a minimal refractive index variation of 2x10-4 RIU, limited by the wavelength resolution of the light source (50 pm). Simulations indicate that the slot region is partially filled when the sensor is exposed to an aqueous solution. We also demonstrate the capability of our sensor to measure higher index fluids such as isopropanol (n=1.37) and cyclohexane (n=1.42)

Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS

The tumor suppressor protein adenomatous polyposis coli (APC) is multifunctional – it participates in the canonical Wnt/β-catenin signal transduction pathway as well as modulating cytoskeleton function. Although APC is expressed by Schwann cells, the role that it plays in these cells and in the myelination of the peripheral nervous system (PNS) is unknown. Therefore, we used the Cre-lox approach to generate a mouse model in which APC expression is specifically eliminated from Schwann cells. These mice display hindlimb weakness and impaired axonal conduction in sciatic nerves. Detailed morphological analyses revealed that APC loss delays radial axonal sorting and PNS myelination. Furthermore, APC loss delays Schwann cell differentiation in vivo, which correlates with persistent activation of the Wnt signaling pathway and results in perturbed extension of Schwann cell processes and disrupted lamellipodia formation. In addition, APC-deficient Schwann cells display a transient diminution of proliferative capacity. Our data indicate that APC is required by Schwann cells for their timely differentiation to mature, myelinating cells and plays a crucial role in radial axonal sorting and PNS myelination

Label-free optical biosensing with slot-waveguides.

We demonstrate label-free molecule detection by using an integrated biosensor based on a Si3N4 /SiO2 slotwaveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/ _ng/mm2_ for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm2 for anti-BSA and BSA, respectively, limited by wavelength resolutio