Relation between Peak Power Output in Sprint Cycling and Maximum Voluntary Isometric Torque Production

From a cycling paradigm, little has been done to understand the relationships between maximal isometric strength of different single joint lower body muscle groups and their relation with, and ability to predict PPO and how they compare to an isometric cycling specific task. The aim of this study was to establish relationships between maximal voluntary torque production from isometric single-joint and cycling specific tasks and assess their ability to predict PPO. Twenty male trained cyclists participated in this study. Peak torque was measured by performing maximum voluntary contractions (MVC) of knee extensors, knee flexors, dorsi flexors and hip extensors whilst instrumented cranks measured isometric peak torque from MVC when participants were in their cycling specific position (ISOCYC). A stepwise regression showed that peak torque of the knee extensors was the only significant predictor of PPO when using SJD and accounted for 47% of the variance. However, when compared to ISOCYC, the only significant predictor of PPO was ISOCYC, which accounted for 77% of the variance. This suggests that peak torque of the knee extensors was the best single-joint predictor of PPO in sprint cycling. Furthermore, a stronger prediction can be made from a task specific isometric task

Reliability and validity of depth camera 3D scanning to determine thigh volume

Gross thigh volume is a key anthropometric variable to predict sport performance and health. Currently, it is either estimated by using the frustum method, which is prone to high inter-and intra-observer error, or using medical imaging, which is expensive and time consuming. Depth camera 3D-imaging systems offer a cheap alternative to measure thigh volume but no between-session reliability or comparison to medical imaging has been made. This experiment established between-session reliability and examined agreement with magnetic resonance imaging (MRI). Forty-eight male cyclists had their thigh volume measured by the depth camera system on two occasions to establish between-session reliability. A subset of 32 participants also had lower body MRIs, through which agreement between the depth camera system and MRI was established. The results showed low between-session variability (CV = 1.7%; Absolute Typical Error = 112 cm3) when measuring thigh volume using the depth camera system. The depth camera systematically measured gross thigh volume 32.6cm3 lower than MRI. These results suggest that depth camera 3D-imaging systems are reliable tools for measuring thigh volume and show good agreement with MRI scanners, providing a cheap and time-saving alternative to medical imaging analysis

Anticipating, experiencing, and overcoming challenges in clinical academic training

BackgroundThis paper builds on studies that have reported on the challenges of pursuing a clinical academic career. Aims This study aims to explore the perceived challenges clinical academic trainees experience, and the ways in which they overcome them. MethodsData collected from clinical academic trainees via an online survey and semi-structured interviews were analysed using thematic analysis. Findings Trainees experience challenges relating to balancing and progressing a clinical academic career and seek to overcome these through self-efficacy and by drawing upon the support of peers, supervisors and mentors.ConclusionClinical academic trainees experience significant challenges as they strive to develop careers in academic medicine. They draw on their own resources and the support of others to help them to overcome these. Relatedly they often act to advocate, advise and support aspiring clinical academics

Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients

Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients.BackgroundIn IgA nephropathy (IgAN), circulating IgA1 molecules display an abnormal pattern of O-glycosylation. This abnormality may potentially contribute to mesangial IgA1 deposition, but this is unproven because the O-glycosylation of mesangial IgA1 has not been analyzed.MethodsIgA1 was eluted from glomeruli isolated from the kidneys of three IgAN patients obtained after nephrectomy or at postmortem. Serum from these patients, other patients with IgAN, and controls was subjected to the same treatment as the glomerular eluates. The O-glycosylation of eluted and serum IgA1 was measured by lectin binding using an enzyme-linked immunosorbent assay-based system.ResultsIn all three cases, the lectin binding of IgA1 eluted from the glomeruli of IgAN patients was markedly higher than that of the serum IgA1 of the same individual, and also all but one of a series of serum IgA1 samples from other patients and controls.ConclusionsThe higher lectin binding of glomerular compared with serum IgA1 suggests that O-glycosylated IgA1 molecules abnormally and selectively deposit in the kidney. These results provide the first evidence that mesangial IgA1 is abnormally O-glycosylated, and support a direct role for abnormal IgA1 O-glycosylation in the mechanism of mesangial IgA deposition in IgAN

Reliabilty of traditional and task specific reference tasks to assess peak muscle activation during two different sprint cycling tests

© 2019 Elsevier Ltd Neuromuscular activation is considered an important determinant sprint cycling performance but requires reliable EMG amplitude measurements to facilitate sensitive assessments. The reliability of EMG measurements during sprint cycling may depend on the sprint cycling test undertaken (isovelocity or isoinertial accelerating), the reference tasks used for normalisation (isometric MVCs of a series of single muscle groups [ISO-SINGJT] or isometric cycling MVCs [ISO-CYC]), and the efficacy of the normalisation. This study aimed to compare the magnitude and between-session reliability of peak muscle activation (peak rmsEMG) during: isovelocity and isoinerital sprint cycling tests; ISO-SINGJT and ISO-CYC reference tasks; and absolute and normalised EMG during the sprint cycling tests. EMG amplitude was measured over six major muscle groups on both legs and all measurements were made over two sessions in a randomised counterbalanced design. Peak rmsEMG was assessed during both ISO-SINGJT and ISO-CYC MVCs and then during mechanical peak power output (PPO) during isovelocity (120 RPM) and isoinerital acceleration (0 to >150 RPM) sprint tests. Absolute peak rmsEMG and for the sprint tests normalised EMG values were determined, and coefficient of variation and intra-class correlation coefficients used to assess reliability. Peak rmsEMG at PPO during both sprint cycling tests was similar for the six muscle groups measured. Peak rmsEMG was higher during ISO-SINGJT than ISO-CYC for for 3 of the 6 muscle groups, but all muscle groups exhibited similar reliability for both reference tasks. Neither reference task improved the between-session reliability for either sprint test. This data highlights reservations in the use of isometric reference tasks to ascertain changes in peak muscle activation over time in during sprint cycling assessments

Effects of strength training on the biomechanics and coordination of short-term maximal cycling.

The aim was to investigate the effects of a gym-based strength training intervention on biomechanics and intermuscular coordination patterns during short-term maximal cycling. Twelve track sprint cyclists performed 3 × 4 s seated sprints at 135 rpm, interspersed with 2 × 4 s seated sprints at 60 rpm on an isokinetic ergometer, repeating the session 11.6 ± 1.4 weeks later following a training programme that included two gym-based strength training sessions per week. Joint moments were calculated via inverse dynamics, using pedal forces and limb kinematics. EMG activity was measured for 9 lower limb muscles. Track cyclists 'leg strength" increased (7.6 ± 11.9 kg, P = 0.050 and ES = 0.26) following the strength training intervention. This was accompanied by a significant increase in crank power over a complete revolution for sprints at 135 rpm (26.5 ± 36.2 W, P = 0.028 and ES = 0.29). The increase in leg strength and average crank power was associated with a change in biceps femoris muscle activity, indicating that the riders successfully adapted their intermuscular coordination patterns to accommodate the changes in personal constraints to increase crank power

Biomechanical measures of short-term maximal cycling on an ergometer: a test-retest study.

An understanding of test-retest reliability is important for biomechanists, such as when assessing the longitudinal effect of training or equipment interventions. Our aim was to quantify the test-retest reliability of biomechanical variables measured during short-term maximal cycling. Fourteen track sprint cyclists performed 3 × 4 s seated sprints at 135 rpm on an isokinetic ergometer, repeating the session 7.6 ± 2.5 days later. Joint moments were calculated via inverse dynamics, using pedal forces and limb kinematics. EMG activity was measured for 9 lower limb muscles. Reliability was explored by quantifying systematic and random differences within- and between-session. Within-session reliability was better than between-sessions reliability. The test-retest reliability level was typically moderate to excellent for the biomechanical variables that describe maximal cycling. However, some variables, such as peak knee flexion moment and maximum hip joint power, demonstrated lower reliability, indicating that care needs to be taken when using these variables to evaluate biomechanical changes. Although measurement error (instrumentation error, anatomical marker misplacement, soft tissue artefacts) can explain some of our reliability observations, we speculate that biological variability may also be a contributor to the lower repeatability observed in several variables including ineffective crank force, ankle kinematics and hamstring muscles' activation patterns