3,341 research outputs found
Cellular automata and non-static image processing for embodied robot systems on a massively parallel processor array
Cellular automata and non-static image processing for embodied robot systems on a massively parallel processor array
RXJ0142.0+2131: I. The galaxy content of an X-ray-luminous galaxy cluster at z=0.28
We present a photometric and spectroscopic study of stellar populations in
the X-ray-luminous cluster of galaxies RXJ0142.0+2131 at z=0.280. This paper
analyses the results of high signal-to-noise spectroscopy, as well as g'-, r'-,
and i'-band imaging, using the Gemini Multi-Object Spectrograph on Gemini
North. Of 43 spectroscopic targets, we find 30 cluster members over a range in
color. Central velocity dispersions and absorption-line strengths for lines in
the range 3700A < lambda_rest < 5800A are derived for cluster members, and are
compared with a low-redshift sample of cluster galaxies, and single stellar
population (SSP) models. We use a combination of these indicators to estimate
luminosity-weighted mean ages, metallicities ([M/H]), and alpha-element
abundance ratios ([alpha/Fe]).
RXJ0142.0+2131 is a relatively poor cluster and lacks galaxies with high
central velocity dispersions. Although the red sequence and the Faber-Jackson
relation are consistent with pure passive evolution of the early-type
population with a formation redshift of z_form = 2, the strengths of the 4000A
break and scaling relations between metal line indices and velocity dispersion
reject this model with high significance. By inverting SSP models for the
Hbeta_G, Mgb, and line indices, we calculate that, at a given velocity
dispersion and metallicity, galaxies in RXJ0142.0+2131 have luminosity-weighted
mean ages 0.14 +- 0.07 dex older than the low-redshift sample. We also find
that [alpha/Fe] in stellar populations in RXJ0142.0+2131 is 0.14 +- 0.03
greater than at low redshift. All scaling relations are consistent with these
estimated offsets. (abridged)Comment: AJ, accepted. 31 pages, 13 figures, uses emulateapj.cls.
High-resolution figures available on request from first autho
Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synthesized novel N-6-substituted purine analogues with ambiguous incorporation characteristics due to tautomerization of the nucleobase. The most potent of these analogues reduced the titer of poliovirus (PV) and coxsackievirus (CVB3) over 1,000-fold during a single passage in HeLa cell culture, with an increase in transition mutation frequency up to 65-fold. Kinetic analysis of incorporation by the PV polymerase indicated that these analogues were templated ambiguously with increased efficiency compared to the known mutagenic nucleoside ribavirin. Notably, these nucleosides were not efficient substrates for cellular ribonucleotide reductase in vitro, suggesting that conversion to the deoxyriboucleoside may be hindered, potentially limiting genetic damage to the host cell. Furthermore, a high-fidelity PV variant (G64S) displayed resistance to the antiviral effect and mutagenic potential of these analogues. These purine nucleoside analogues represent promising lead compounds in the development of clinically useful antiviral therapies based on the strategy of lethal mutagenesis
Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis
ABSTRACT Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection.
A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained at the start and end of the treatment period. Additional data were available for 29 of these patients when they were clinically stable.
Cross-sectionally, quorum sensing signal molecules were detectable in the sputum, plasma and urine of 86%, 75% and 83% patients, respectively. They were positively correlated between the three biofluids. Positive correlations were observed for most quorum sensing signal molecules in sputum, plasma and urine, with quantitative measures of pulmonary P. aeruginosa load at the start of a pulmonary exacerbation. Plasma concentrations of 2-nonyl-4-hydroxy-quinoline (NHQ) were significantly higher at the start of a pulmonary exacerbation compared to clinical stability ( p<0.01). Following the administration of systemic antibiotics, plasma 2-heptyl-4-hydroxyquinoline ( p=0.02) and NHQ concentrations (p<0.01) decreased significantly.
In conclusion, quorum sensing signal molecules are detectable in cystic fibrosis patients with pulmonary P. aeruginosa infection and are positively correlated with quantitative measures of P. aeruginosa. NHQ correlates with clinical status and has potential as a novel biomarker for P. aeruginosa infection
Constant photocurrent method to probe the sub-bandgap absorption in wide bandgap semiconductor films : the case of α-Ga2O3
The optical absorption coefficient is one of the fundamental properties of semiconductors and is critical to the development of optical devices. Herein, a revival of the constant photocurrent method is presented to measure sub-bandgap absorption in wide bandgap semiconductor films. The method involves maintaining a constant photocurrent by continually adjusting the impinging photon flux across the energy spectrum. Under such conditions, the reciprocal of the photon flux for uniformly absorbed light is proportional to the absorption coefficient. This method is applied to α-Ga 2O 3 and reveals that it can access the absorption coefficient from 1 Ă 10 5 cm â1 at the band edge (5.3 eV) to 0.8 cm â1 close to mid-bandgap (2.7 eV). Changes in the steepness of the absorption curve in the sub-bandgap region are in excellent agreement with defect states of α-Ga 2O 3 reported by deep level transient spectroscopy, indicating that the technique shows promise as a probe of energetically distributed defect states in thin film wide bandgap semiconductors
Yukawa Unification and the Superpartner Mass Scale
Naturalness in supersymmetry (SUSY) is under siege by increasingly stringent
LHC constraints, but natural electroweak symmetry breaking still remains the
most powerful motivation for superpartner masses within experimental reach. If
naturalness is the wrong criterion then what determines the mass scale of the
superpartners? We motivate supersymmetry by (1) gauge coupling unification, (2)
dark matter, and (3) precision b-tau Yukawa unification. We show that for an
LSP that is a bino-Higgsino admixture, these three requirements lead to an
upper-bound on the stop and sbottom masses in the several TeV regime because
the threshold correction to the bottom mass at the superpartner scale is
required to have a particular size. For tan beta about 50, which is needed for
t-b-tau unification, the stops must be lighter than 2.8 TeV when A_t has the
opposite sign of the gluino mass, as is favored by renormalization group
scaling. For lower values of tan beta, the top and bottom squarks must be even
lighter. Yukawa unification plus dark matter implies that superpartners are
likely in reach of the LHC, after the upgrade to 14 (or 13) TeV, independent of
any considerations of naturalness. We present a model-independent, bottom-up
analysis of the SUSY parameter space that is simultaneously consistent with
Yukawa unification and the hint for m_h = 125 GeV. We study the flavor and dark
matter phenomenology that accompanies this Yukawa unification. A large portion
of the parameter space predicts that the branching fraction for B_s to mu^+
mu^- will be observed to be significantly lower than the SM value.Comment: 34 pages plus appendices, 20 figure
Spontaneous Autologous Graft-versus-Host Disease in Plasma Cell Myeloma Autograft Recipients: Flow Cytometric Analysis of Hematopoietic Progenitor Cell Grafts
Nine plasma cell myeloma patients spontaneously developed histologically proven autologous graft-versus-host disease (GVHD) limited predominantly to the gastrointestinal tract within 1 month of initial autologous hematopoietic cell transplantation (AHCT) using high-dose melphalan conditioning. All recipients responded promptly to systemic and nonabsorbable oral corticosteroid therapy. All patients previously received systemic therapy with thalidomide, lenalidomide, or bortezomib before AHCT. Using enzymatic amplification staining-enhanced flow cytometry, we evaluated expression of selected transcription regulators, pathway molecules, and surface receptors on samples of the infused hematopoietic cell grafts. We demonstrated significantly enhanced expression of GATA-2, CD130, and CXCR4 on CD34+ hematopoietic progenitor cells of affected patients compared with 42 unaffected AHCT controls. These 3 overexpressed markers have not been previously implicated in autologous GVHD. Although we did not specifically evaluate T cells, we postulate that exposure over time to the various immunomodulating therapies used for induction treatment affected not only the CD34+ cells but also T cells or relevant T cell subpopulations capable of mediating GVHD. After infusion, the affected hematopoietic progenitor cells then encounter a host that has been further altered by the high-dose melphalan preparative regimen; such a situation leads to the syndrome. These surface markers could be used to develop a model to predict development of this syndrome. Autologous GVHD potentially is a serious complication of AHCT and should be considered in plasma cell myeloma patients with otherwise unexplained gastrointestinal symptoms in the immediate post-AHCT period. Prompt recognition of this condition and protracted treatment with nonabsorbable or systemic corticosteroids or the combination may lead to resolution
In utero exposure to atrazine analytes and early menarche in the Avon Longitudinal Study of Parents and Children Cohort
Background: Evidence from experimental studies suggests that atrazine and its analytes alter the timing of puberty in laboratory animals. Such associations have not been investigated in humans.
Objective: To determine the association between in utero exposure to atrazine analytes and earlier menarche attainment in a nested case-control study of the population-based Avon Longitudinal Study of Parents and Children.
Methods: Cases were girls who reported menarche before 11.5 years while controls were girls who reported menarche at or after 11.5 years. Seven atrazine analyte concentrations were measured in maternal gestational urine samples (sample gestation week median (IQR): 12 (8â17)) during the period 1991â1992, for 174 cases and 195 controls using high performance liquid chromatography-tandem mass spectrometry. We evaluated the study association using multivariate logistic regression, adjusting for potential confounders. We used multiple imputation to impute missing confounder data for 29% of the study participants.
Results: Diaminochlorotriazine (DACT) was the most frequently detected analyte (58%\u3elimit of detection [LOD]) followed by desethyl atrazine (6%), desethyl atrazine mercapturate (3%), atrazine mercapturate (1%), hydroxyl atrazine (1%), atrazine (1%) and desisopropyl atrazine (0.5%). Because of low detection of other analytes, only DACT was included in the exposureâoutcome analyses. The adjusted odds of early menarche for girls with DACT exposuresâ„median was 1.13 (95% Confidence Interval [95% CI]:0.82, 1.55) and exposure
Conclusions: This study is the first to examine the association between timing of menarche and atrazine analytes. We found a weak, non-significant association between in-utero exposure to atrazine metabolite DACT and early menarche, though the association was significant in the subset of girls with complete confounder information. Further exploration of the role of these exposures in female reproduction in other cohorts is needed
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
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