Chapter Lake Garda lemon houses: a mediterranean landscape in an internal lake

Lemon houses (limonaie) are ancient terraced citrus gardens that shape the landscape along the NW shore of Lake Garda (Northern Italy). We propose an interpretation of limonaie as a deeply anthropogenic, labour intensive, multifunctional landscape that shares many characteristics with the oases of the wider Mediterranean basin. Any intervention which aims at preserving the fragility and peculiarity of the area, as well as the intangible cultural heritage of the citrus cultivation, should be framed in a holistic agroecosystemic perspective, deeply rooted in the knowledge of the limonaie past

The Impact of Meteorological Drought on Vegetation Health in the Middle Euphrates River Basin (Syria)

Syria is now witnessing the dramatic effects of a multiyear drought that has been afflicting the country since 2006. The drought has impacted several regions, but the north-eastern Al Jazira region, corresponding to the Middle Euphrates River basin and considered the Syrian “breadbasket”, has been hammered particularly severely

Land cover changes since the 19th century detected from historic maps for environmental applications: toward a “CORINE 1800” project?

The value of cartographic heritage for environmental applications is demonstrated with a test case in the Central Italian Alps. Land cover changes since the early 19th century are detected from sample maps of the Second Military Survey of the Habsburg Empire in Lombardy (1818-1829), available on the portal www.mapire.eu. They are compared with 1954 areal sur-veys and successive land cover classification until 2018. Issues as land use classes homogeni-zation, data vectorization, georeferencing errors are addressed. The dynamics of main land cover classes (woods, bush, meadows, crops) are investigated on sample areas and the potential use of this exercise for hydrological applications is explored. In fact, the impact of the observed natural afforestation on changes in hydrological losses due to evapotranspiration and its influ-ence as a likely cause for the decrease in runoff monitored since 1845 in the Adda river basin and needs to be assessed in a systematic way. The proposed test case can pave the road for a project extended at European scale, a sort of “CORINE 1800 land cover” Geographic Infor-mation System, which could have several environmental, cartographic and socio-economic ap-plications

Profiles and species of Mn, Fe and trace metals in soils near a ferromanganese plant in Bagnolo Mella (Brescia, IT)

For the last forty-five years (from 1974 to present) ferroalloy production in Bagnolo Mella, Northern Italy, has generated particulate emissions enriched in potentially toxic metals and metalloids including arsenic (As), lead (Pb) and manganese (Mn). Of these, Mn is unique in that it has a significant background concentration and is seldom studied as a contaminant but is potentially a significant toxin derived from dusts regionally. Here we examine the distribution, redistribution, speciation and bioavailability of the Mn-contaminated top soils affected by atmospheric emissions adjacent to the ferroalloy plant. Four sites, variably located in the study area in terms of both distance and direction from the plant, were considered as representative of increasing levels of industrial influence. Soil profiles showed that metal concentrations (measured by X-ray fluorescence) varied considerably by location, i.e. higher in the sites closer to the plant and also at the surface level, although distributed throughout the top 15 cm, suggesting appreciable redistribution possibly due to soil mixing or infiltration. Most metal concentrations were correlated, except Mn which was independent and more variable across the sites than the other elements. Sequential chemical extractions indicated that Pb was primarily associated with Mn oxides, while As was most significantly associated with iron oxides. When Mn concentration significantly exceeded background levels, it was present in phases that were resistant to acid dissolution, very different from typical uncontaminated soils. X-ray Absorption Near Edge Spectroscopy (XANES) analyses suggested this recalcitrant Mn phase is likely a Mn-bearing spinel such as magnetite, that can be particularly toxic if ingested or inhaled. These first results highlight the legacy of ferroalloy production on surrounding soils, as well as the importance of Mn speciation for soil apportionment evaluation and human exposure estimation

Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer

Background: genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. Methods: we performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries. Results: we did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (Ptrend of = 0.0071). Conclusions: our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts

mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery

et al.[Objective]: Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that has been proposed to play a protective role in mouse models of cardiac ischemia and heart failure, suggesting that PGC-1α could be relevant as a prognostic marker. Our previous studies showed that the estimation of peripheral mRNA PGC-1α expression was feasible and that its induction correlated with the extent of myocardial necrosis and left ventricular remodeling in patients with myocardial infarction. In this study, we sought to determine if the myocardial and peripheral expressions of PGC-1α are well correlated and to analyze the variability of PGC-1α expression depending on the prevalence of some metabolic disorders. [Methods]: This was a cohort of 35 consecutive stable heart failure patients with severe aortic stenosis who underwent an elective aortic valve replacement surgery. mRNA PGC-1α expression was simultaneously determined from myocardial biopsy specimens and blood samples obtained during surgery by quantitative PCR, and a correlation between samples was made using the Kappa index. Patients were divided into two groups according to the detection of baseline expression levels of PGC-1α in blood samples, and comparisons between both groups were made by chi-square test or unpaired Student’s t-test as appropriate. [Results]: Based on myocardial biopsies, we found that mRNA PGC-1α expression in blood samples showed a statistically significant correlation with myocardial expression (Kappa index 0.66, p<0.001). The presence of higher systemic PGC-1α expression was associated with a greater expression of some target genes such as silent information regulator 2 homolog-1 (x-fold expression in blood samples: 4.43±5.22 vs. 1.09±0.14, p=0.044) and better antioxidant status in these patients (concentration of Trolox: 0.40±0.05 vs. 0.34±0.65, p=0.006). [Conclusions]: Most patients with higher peripheral expression also had increased myocardial expression, so we conclude that the non-invasive estimation of mRNA PGC-1α expression from blood samples provides a good approach of the constitutive status of the mitochondrial protection system regulated by PGC-1α and that this could be used as prognostic indicator in cardiovascular disease.Grant from Sociedad Valenciana de Cardiología, 2013 to Óscar Fabregat-Andrés.Peer Reviewe

Corso di Idraulica e Idrologia agraria

Nel Corso di Idraulica e Idrologia agraria sono raccolti gli appunti scritti, a partire dall’A.A.2020/2021, per fornire agli studenti un robusto supporto di studio durante i periodi di confinamento e di lezioni telematiche richiesti dalla pandemia allora in corso. Il libro è organizzato in tre capitoli: Acqua e clima, Idraulica, Idrologia del suol

Dal suolo, al deserto, all'oasi

Il contributo propone un aproccio multidimensionale e interdisciplinare alla desertificazione, che tenga conto della grande varietà e complessità dei fenomeni coinvolti nel processo, e quindi della varietà e complessità delle risorse non solo naturali, ma anche culturali, cui si può attingere per combatterla

Le oasi del Garda

Lo studio del sistema idraulico tradizionale delle limonaie rivela le analogie fra questi metodi e l’agricoltura praticata nei deserti, mettendo i nostri “giardini d’agrumi terrazzati” in relazione con ecosistemi e percorsi culturali sovranazionali