1,794 research outputs found
Company environmental and societal positions as sources of competitive advantage: Implications for sustainable agriculture producers
Use of an environmental positioning strategy can help small-scale agricultural producers present their products to consumers in a more appealing manner
Emerging Issues for Geographical Indication Branding Strategies
Branding strategies centering on the geographical origins of a product can provide a basis for differentiating commodity products. The use of such geographical indications (or GIs) can involve unique quality characteristics associated with a particular location or quality images that are based on the history, tradition, and folklore in a region. In this paper we describe the benefits and pitfalls (such as the threat of new entrants, oversupply, the broadening of boundaries to include more producers, and limiting generic use of such names) of using GI branding strategies. We also focus on trademark issues germane to a company\u27s ability to (1) adopt GI-based trademarks as a means of gaining a competitive advantage and (2) protect the rights associated with such marks in order to sustain this source of competitive advantage
Company environmental and societal positions as sources of competitive advantage: Consumer- and retailer-level effects
Smaller producers need to differentiate themselves from larger operations to ensure their economic survival. One way to do this is to market their products as being environmentally friendly and/or socially responsible
Emerging Forms of Competitive Advantage: Implications for Agricultural Producers
Traditional recommendations for building sustainable competitive advantages revolve around differentiating a product from the competition along attributes that are important and relevant to customers. However, strategic approaches based on such notions do not represent viable options for companies competing in commodity markets characterized by a lack of physical product differentiation. The objective of this paper is to conduct a literature review with the aim of identifying alternative approaches to creating competitive advantage that can be used even under conditions in which no differences in actual quality exist across products. This review of the literature uncovered three non-traditional strategies that provide a basis for perceptually differentiating products in the face of physical homogeneity. Agricultural producers operating in parity markets should consider these recommendations when developing strategies aimed at creating the competitive advantages that drive sales performance in the marketplace
Graphene Nano-Ribbon Electronics
We have fabricated graphene nano-ribbon field-effect transistor devices and
investigated their electrical properties as a function of ribbon width. Our
experiments show that the resistivity of a ribbon increases as its width
decreases, indicating the impact of edge states. Analysis of temperature
dependent measurements suggests a finite quantum confinement gap opening in
narrow ribbons. The electrical current noise of the graphene ribbon devices at
low frequency is found to be dominated by the 1/f noise.Comment: 6 pages, 7 figure
A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers
Infectious prions contain a self-propagating, misfolded conformer of the prion protein termed PrPSc. A critical prediction of the protein-only hypothesis is that autocatalytic PrPSc molecules should be infectious. However, some autocatalytic recombinant PrPSc molecules have low or undetectable levels of specific infectivity in bioassays, and the essential determinants of recombinant prion infectivity remain obscure. To identify structural and functional features specifically associated with infectivity, we compared the properties of two autocatalytic recombinant PrP conformers derived from the same original template, which differ by \u3e105-fold in specific infectivity for wild-type mice. Structurally, hydrogen/deuterium exchange mass spectrometry (DXMS) studies revealed that solvent accessibility profiles of infectious and non-infectious autocatalytic recombinant PrP conformers are remarkably similar throughout their protease-resistant cores, except for two domains encompassing residues 91-115 and 144-163. Raman spectroscopy and immunoprecipitation studies confirm that these domains adopt distinct conformations within infectious versus non-infectious autocatalytic recombinant PrP conformers. Functionally, in vitro prion propagation experiments show that the non-infectious conformer is unable to seed mouse PrPC substrates containing a glycosylphosphatidylinositol (GPI) anchor, including native PrPC. Taken together, these results indicate that having a conformation that can be specifically adopted by post-translationally modified PrPC molecules is an essential determinant of biological infectivity for recombinant prions, and suggest that this ability is associated with discrete features of PrPSc structure
A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers
Infectious prions contain a self-propagating, misfolded conformer of the prion protein termed PrPSc. A critical prediction of the protein-only hypothesis is that autocatalytic PrPSc molecules should be infectious. However, some autocatalytic recombinant PrPSc molecules have low or undetectable levels of specific infectivity in bioassays, and the essential determinants of recombinant prion infectivity remain obscure. To identify structural and functional features specifically associated with infectivity, we compared the properties of two autocatalytic recombinant PrP conformers derived from the same original template, which differ by \u3e105-fold in specific infectivity for wild-type mice. Structurally, hydrogen/deuterium exchange mass spectrometry (DXMS) studies revealed that solvent accessibility profiles of infectious and non-infectious autocatalytic recombinant PrP conformers are remarkably similar throughout their protease-resistant cores, except for two domains encompassing residues 91-115 and 144-163. Raman spectroscopy and immunoprecipitation studies confirm that these domains adopt distinct conformations within infectious versus non-infectious autocatalytic recombinant PrP conformers. Functionally, in vitro prion propagation experiments show that the non-infectious conformer is unable to seed mouse PrPC substrates containing a glycosylphosphatidylinositol (GPI) anchor, including native PrPC. Taken together, these results indicate that having a conformation that can be specifically adopted by post-translationally modified PrPC molecules is an essential determinant of biological infectivity for recombinant prions, and suggest that this ability is associated with discrete features of PrPSc structure
The SAMI Galaxy Survey: gravitational potential and surface density drive stellar populations -- I. early-type galaxies
The well-established correlations between the mass of a galaxy and the
properties of its stars are considered evidence for mass driving the evolution
of the stellar population. However, for early-type galaxies (ETGs), we find
that color and stellar metallicity [Z/H] correlate more strongly with
gravitational potential than with mass , whereas stellar population
age correlates best with surface density . Specifically, for our sample
of 625 ETGs with integral-field spectroscopy from the SAMI Galaxy Survey,
compared to correlations with mass, the color--, [Z/H]--, and
age-- relations show both smaller scatter and less residual trend with
galaxy size. For the star formation duration proxy [/Fe], we find
comparable results for trends with and , with both being
significantly stronger than the [/Fe]- relation. In determining the
strength of a trend, we analyze both the overall scatter, and the observational
uncertainty on the parameters, in order to compare the intrinsic scatter in
each correlation. These results lead us to the following inferences and
interpretations: (1) the color-- diagram is a more precise tool for
determining the developmental stage of the stellar population than the
conventional color--mass diagram; and (2) gravitational potential is the
primary regulator of global stellar metallicity, via its relation to the gas
escape velocity. Furthermore, we propose the following two mechanisms for the
age and [/Fe] relations with : (a) the age-- and
[/Fe]-- correlations arise as results of compactness driven
quenching mechanisms; and/or (b) as fossil records of the
relation in their disk-dominated progenitors.Comment: 9 pages, 4 figures, 1 table Accepted to Ap
Atrazine and cancer incidence among pesticide applicators in the agricultural health study (1994-2007).
Atrazine is a triazine herbicide used widely in the United States. Although it is an animal carcinogen, the mechanism in rodents does not appear to operate in humans. Few epidemiologic studies have provided evidence for an association
Tuberous sclerosis complex exhibits a new renal cystogenic mechanism
Tuberous sclerosis complex (TSC) is a tumor predisposition syndrome with significant renal cystic and solid tumor disease. While the most common renal tumor in TSC, the angiomyolipoma, exhibits a loss of heterozygosity associated with disease, we have discovered that the renal cystic epithelium is composed of type A intercalated cells that have an intact Tsc gene that have been induced to exhibit Tsc‐mutant disease phenotype. This mechanism appears to be different than that for ADPKD. The murine models described here closely resemble the human disease and both appear to be mTORC1 inhibitor responsive. The induction signaling driving cystogenesis may be mediated by extracellular vesicle trafficking.TSC renal cystic disease develops in about half of the patients. The disease appears to caused by an induction mechanism such that a small population of mutant cells can cause significant renal cystic disease comprised of mostly genetically normal cells.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147796/1/phy213983.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147796/2/phy213983_am.pd
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