Atrazine is a triazine herbicide used widely in the United States. Although it is an animal carcinogen, the mechanism in rodents does not appear to operate in humans. Few epidemiologic studies have provided evidence for an association

Aaron Blair

Alavanja MC

Cantor K

Cynthia J. Hines

Dale P. Sandler

Dosemeci M

European Commission

Francesco Barone-Adesi

Gabriella Andreotti

Hines CJ

IARC (International Agency for Research on Cancer)

Jane A. Hoppin

Jay H. Lubin

Jennifer A. Rusiecki

Jennifer Sloan

Joseph B. Coble

Laura E. Beane Freeman

Michael C.R. Alavanja

Mills PK

Shelia Hoar Zahm

Sokic SI

Stella Koutros

Trentacoste S

Waggoner J

Environmental Health Perspectives

English

Freeman, LE

Rusiecki, JA

Hoppin, JA

Lubin, JH

Koutros, S

Andreotti, G

Zahm, SH

Hines, CJ

Coble, JB

Barone-Adesi, F

Sloan, J

Sandler, DP

Blair, A

Alavanja, MC

St George's Online Research Archive

A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 46:245–260.

A risk assessment of atrazine use in California: human health and ecological aspects. Pest Manag Sci 61:331–355.

Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study.

Agency for Research on Cancer).

Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma.

Agricultural risk factors for t(14;18) subtypes of non-Hodkins lymphoma.

An update of cancer incidence in the Agricultural Health Study J Occup Environ Med 52:1098–1105.

Assessment of a pesticide exposure intensity algorithm in the Agricultural Health Study.

Atmospheric transport, deposition, and fate of triazine herbicides and their metabolites in pristine areas at Isle Royale National Park. Environ Sci Technol 34:3079–3085.

Atrazine and cancer in the Agricultural Health Study Environmental Health Perspectives •

Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats.

Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis).

Atrazine inhibition of testosterone production in rat males following peripubertal exposure. Reprod Toxicol 16:275–279.

Atrazine Science Reevaluation: Potential Health Impacts. Available: www.epa.gov/oppsrrd1/reregistration/atrazine/ atrazine_update.htm [accessed 31

Breast cancer incidence and its possible spatial association with pesticide application in two counties of England. Public Health 118:513–520.

Cancer incidence among a cohort of female farm residents in New York State. Arch Environ Health 57:561–567.

Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study.

Cancer incidence among triazine herbicide manufacturing workers.

Cancer incidence in the Agricultural Health Study.

Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study. Ann Occup Hyg 52:153–166.

concerning the non-inclusion of atrazine in Annex I to Council Directive 91/414/EEC and the withdrawal of authorisations for plant protection products containing this active substance,

Current-use pesticides and organochlorine compounds in precipitation and lake sediment from two high-elevation national parks in the Western United States. Arch Environ Contam Toxicol 52:294–305.

Effects of atrazine on fish, amphibians, and aquatic reptiles: a critical review. Crit Rev Toxicol 38:721–772.

Effects of in ovo exposure to imazalil and atrazine on sexual differentiation in chick gonads. Poult Sci 85:1641–1647.

Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 30:293–342.

Environmental Health Perspectives residents in New York indicated a nonsignificant increased standardized incidence ratio for thyroid cancer, but without evaluation of specific exposures

Environmental Protection Agency).

Estrous cycle patterns of Sprague-Dawley rats during acute and chronic atrazine administration. Reprod Toxicol 13:491–499.

Geographic and temporal distribution of herbicides in surface waters of the upper Midwestern United States,

Handlers Exposure Database).

Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses.

Integrative assessment of multiple pesticides as risk factors for non- Hodgkin’s lymphoma among men. Occup Environ Med 60:E11.

Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Food Chem Toxicol 41:1811–1816.

Mechanistic effects of a triazine pesticide on reproductive endocrine function in mature male Atlantic salmon (Salmo solar L.) parr. Pestic Biochem Physiol 62:41–50.

Mortality among triazine herbicide manufacturing workers.

Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of 5 prospective studies. Cancer Epidemiol Biomarkers Prev 20:464–472.

Pesticide exposures and multiple myeloma in Iowa men. Cancer Causes Control 4:153–156.

Pesticide use and breast cancer risk among farmers’ wives in the agricultural health study.

Pesticide use and thyroid disease among women in the Agricultural Health Study.

Pesticides and other agricultural risk factors for non-Hodgkin’s lymphoma among men in Iowa and Minnesota. Cancer Res 52:2447–2455.

Regional assessment of atrazine exposure and incidence of breast and ovarian cancers in Kentucky. Arch Environ Contam Toxicol 42:127–136.

Regression analysis of pesticide use and breast cancer incidence in California Latinas.

Reliability of reporting on lifestyle and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa. Epidemiology 13:94–99.

Risk factors for thyroid cancer.

Role of the herbicide atrazine in the development of non-Hodgkin’s lymphoma.

The effect of atrazine on puberty in male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol Sci 58:50–59.

The effects of atrazine on female Wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicol Sci 58:366–376.

The role of agricultural pesticide use in the development of non-Hodgkin’s lymphoma in women. Arch Environ Health 48:353–358.

Triazine herbicides and epithelial ovarian cancer risk in central California.

Triazine herbicides and ovarian epithelial neoplasms.

Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study.

Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort.

Atrazine and cancer incidence among pesticide applicators in the agricultural health study (1994-2007).

BACKGROUND:Atrazine is a triazine herbicide used widely in the United States. Although it is an animal carcinogen, the mechanism in rodents does not appear to operate in humans. Few epidemiologic studies have provided evidence for an association.
METHODS:The Agricultural Health Study (AHS) is a prospective cohort that includes 57,310 licensed pesticide applicators. In this report, we extend a previous AHS analysis of cancer risk associated with self-reported atrazine use with six additional years of follow-up and more than twice as many cancer cases. Using Poisson regression, we calculated relative risk estimates and 95% confidence intervals for lifetime use of atrazine and intensity-weighted lifetime days, which accounts for factors that impact exposure.
RESULTS:Overall, 36,357 (68%) of applicators reported using atrazine, among whom there were 3,146 cancer cases. There was no increase among atrazine users in overall cancer risk or at most cancer sites in the higher exposure categories compared with the lowest. Based on 29 exposed cases of thyroid cancer, there was a statistically significant risk in the second and fourth quartiles of intensity-weighted lifetime days. There was a similar pattern for lifetime days, but neither the risk estimates nor the trend were statistically significant and for neither metric was the trend monotonic.
CONCLUSIONS:Overall, there was no consistent evidence of an association between atrazine use and any cancer site. There was a suggestion of increased risk of thyroid cancer, but these results are based on relatively small numbers and minimal supporting evidence

Beane Freeman LE

Rusiecki JA

Hoppin JA

Lubin JH

Koutros S

Andreotti G

Hoar Zahm S

Coble JB

Sloan J

Sandler DP

Blair A

Alavanja M.C.R.

BARONE ADESI, Francesco

Archivio Istituzionale della Ricerca- Università del Piemonte Orientale

Atrazine and cancer incidence among pesticide applicators in the Agricultural Health Study (1994-2007).

Crossref

Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994–2007)

L. B. Freeman

J. Rusiecki

J. Hoppin

J. Lubin

S. Koutros

G. Andreotti

S. H. Zahm

C. Hines

J. Coble

F. Barone-Adesi

J. Sloan

D. Sandler

A. Blair

M. Alavanja

Occupational and Environmental Medicine

Atrazine and cancer incidence among pesticide applicators in the Agricultural Health Study (1994-2007)

https://iris.uniupo.it/bitstream/11579/70849/2/freeman11.pdf

Atrazine and cancer incidence among pesticide applicators in the agricultural health study (1994-2007).

Abstract

Similar works

Full text

Available Versions

St George's Online Research Archive

Archivio Istituzionale della Ricerca- Università del Piemonte Orientale

Crossref

Crossref