The Economic Effects of Malaria Eradication: Evidence from an Intervention in Uganda

This study evaluates the economic consequences of a malaria eradication campaign in the southwestern Ugandan district of Kigezi. The project was a joint venture between the WHO and Uganda's Ministry of Health, designed to test for the first time the feasibility of malaria eradication in a sub-Saharan African country. During the years of 1959 and 1960, eradication efforts employing DDT spraying and mass distribution of anti-malarials were implemented, beginning in northern Kigezi. Follow-up studies reported a drop in overall parasite rates from 22.7 to 0.5% in hyperendemic areas and from 12.5 to 0% in mesoendemic areas. We use this campaign as a plausibly exogenous health shock to explore changes in human-capital formation and income. We employ a difference-in-difference methodology to show that eradication produced differential improvements in Kigezi compare to the rest of Uganda in years of schooling, literacy, and primary school completion. In addition, we find suggestive evidence that eradication increased income levels.human capital, malaria, economic development and health

Maternal Well-Being, Child Care, and Children's Development in Families Eligile for Subsidies

Child-care subsidies (CCDF) were expanded after welfare reform in 1996 to help low-income families pay for child-care. Descriptive studies have been conducted on the relationship of subsidies to maternal work characteristics, but there is limited research on the extent to which CCDF is related to factors of maternal well-being. Although many studies have examined the relation between subsidy-use and child care type and quality, few studies have included child developmental outcomes as they relate to subsidy-use. A subsample of subsidy eligible mothers and their children from the Three-Year In-Home and Three-Year Child Care Study of the Fragile Families and Child Well-Being Study were used to examine these relationships. Propensity score matching was used to limit the sample and group code analysis and structural equation modeling were used to test the relationships between maternal well-being, child care and children's development. Finally, multiple group comparisons and latent class analyses with known groups were conducted to assess the invariance of the relationships in the models across families in states with divergent policy considerations. The results indicate that although subsidy use is not independently related to children's developmental outcomes, maternal well-being and child care quality are. Interactions between well-being, quality and subsidy-use were also found to be related to behavior problems and vocabulary. These relationships varied depending on choices states make about CCDF implementation. Implications of these findings and directions for future research are discussed

A Constant-Momentum/Energy-Selector Time-of-Flight Mass Spectrometer

A matrix assisted laser desorption/ionization time-of-flight mass spectrometer has been built with an ion source that can be operated in either constant-energy or constant-momentum acceleration modes. A decreasing electric field distribution in the ion-accelerating region makes it possible to direct ions onto a space-focal plane in either modes of operation. Ions produced in the constant-momentum mode have velocities and, thus, flight times that are linearly dependent on mass and kinetic energies that are inversely dependent on mass. The linear mass dispersion doubles mass resolving power of ions accelerated with space-focusing conditions in constant-momentum mode. The mass-dependent kinetic energy is exploited to disperse ions according to mass in a simple kinetic energy filter constructed from two closely spaced, oblique ion reflectors. Focusing velocity of ions of the same mass can substantially improve ion selection for subsequent post source decay or tandem time-of-flight analyses

Discharge suppression system for a double focusing, atmospheric pressure ionization mass spectrometer

An electrical discharge suppression system for a medium throughput (∼2 l/s) pumping line has been devised that works up to potentials of ±15 kV. This device permits atmospheric pressure ionization sources to be interfaced to high-resolution, magnetic sector mass spectrometers with source potentials of 6-10 k

Trials and tribulations: understanding motivations for clinical research participation amongst adults with cystic fibrosis

In the context of understanding motivations for clinical research participation, many authors consider issues such as informed consent and how patients perceive the research method and process. However, many investigations focus only on one method of research, most commonly the randomised controlled trial. Understanding how chronically ill members of one specific patient group respond to all requests for research participation are rare. Cystic fibrosis (CF), a genetic condition whereby those affected are used to taking a wide array of treatments and attending a specialist care centre over many years, and are generally knowledgeable about their condition, represents an ideal case for investigating how staff requests for clinical research participation are accepted or declined. Using Bloor's systems of relevance framework for risk behaviour and risk reduction, specialist CF centre patients' motivations for participation or non-participation in clinical research can be understood. The framework takes into account two sets of conceptual oppositions: habituation and calculation, constraint and volition. These oppositions represent a range along a continuum of risk behaviour rather than being absolute distinctions. Decisions to participate are influenced mainly by the patient's state of health at the time of request, the nature of the trial and the social context within which sufferers are placed. Understanding why chronically ill patients refuse some requests and yet accept others may assist researchers in designing protocols that take these factors into account and achieve the desired numbers of participants whilst protecting those in vulnerable positions. © 2005 Elsevier Ltd. All rights reserved

Estimating Population Cause-Specific Mortality Fractions from in-Hospital Mortality: Validation of a New Method

Working in Mexico and using vital registration data, Chris Murray and colleagues achieved encouraging results with a new method to estimate population cause-specific mortality fractions

Quantification of Dissolved and Particulate Polyunsaturated Aldehydes in the Adriatic Sea

Polyunsaturated aldehydes (PUA) are supposed to play critical roles in chemically-mediated plankton interactions. Laboratory studies suggest that they act as mediators of chemical defense and chemical communication. PUA are oxylipins containing an α,β,γ,δ–unsaturated aldehyde structure element and are mainly found in diatoms. We present here a detailed surface mapping of PUA during a spring bloom of the diatom Skeletonema marinoi in the Adriatic Sea. We monitored dissolved PUA, as well as particulate PUA, which are produced by phytoplankton after cell disintegration. Our survey revealed a patchy distribution of PUA and shows that at most stations S. marinoi is the major contributor to the overall PUA. Our data also suggest that lysis of a diatom bloom can contribute significantly to the dissolved PUA concentrations and that other producers, which are smaller in cell size compared to diatoms, have to be taken into account as well if the total PUA content of marine samples is considered. The analyses of samples collected in deeper water suggests that diatom contribution to PUA decreases with depth, while smaller-sized unidentified organisms take place as dominant contributors to the PUA concentrations

ECD of Tyrosine Phosphorylation in a Triple Quadrupole Mass Spectrometer with a Radio-Frequency-Free Electromagnetostatic Cell

A radio frequency-free electromagnetostatic (EMS) cell devised for electron-capture dissociation (ECD) of ions has been retrofitted into the collision-induced dissociation (CID) section of a triple quadrupole mass spectrometer to enable recording of ECD product-ion mass spectra and simultaneous recording of ECD-CID product-ion mass spectra. This modified instrument can be used to produce easily interpretable ECD and ECD-CID product-ion mass spectra of tyrosine-phosphorylated peptides that cover over 50% of their respective amino-acid sequences and readily identify their respective sites of phosphorylation. ECD fragmentation of doubly protonated, tyrosine-phosphorylated peptides, which was difficult to observe with FT-ICR instruments, occurs efficiently in the EMS cell