4,304 research outputs found
One-pot silyl ketene acetal-formation-MukaiyamaâMannich additions to imines mediated by trimethylsilyl trifluoromethanesulfonate
In the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base, thioesters are readily converted to silyl ketene acetals in situ and undergo MukaiyamaâMannich addition to N-phenylimines in one pot. The silyl triflates appears to play two roles, activating both the thioester and the imine. This process also works well when thioesters are replaced with amides, esters, or ketones. Products are isolated as desilylated anilines without the necessity of a deprotection step. Yields range from 65-99%
Pulse-mode quantum projection synthesis: Effects of mode mismatch on optical state truncation and preparation
Quantum projection synthesis can be used for phase-probability-distribution
measurement, optical-state truncation and preparation. The method relies on
interfering optical lights, which is a major challenge in experiments performed
by pulsed light sources. In the pulsed regime, the time frequency overlap of
the interfering lights plays a crucial role on the efficiency of the method
when they have different mode structures. In this paper, the pulsed mode
projection synthesis is developed, the mode structure of interfering lights are
characterized and the effect of this overlap (or mode match) on the fidelity of
optical-state truncation and preparation is investigated. By introducing the
positive-operator-valued measure (POVM) for the detection events in the scheme,
the effect of mode mismatch between the photon-counting detectors and the
incident lights are also presented.Comment: 11 pages, 4 figures, submitted to Phys. Rev.
Impact of KRAS mutation status on the efficacy of immunotherapy in lung cancer brain metastases
Immune checkpoint inhibitors (ICIs) have resulted in improved outcomes in non-small cell lung cancer (NSCLC) patients. However, data demonstrating the efficacy of ICIs in NSCLC brain metastases (NSCLCBM) is limited. We analyzed overall survival (OS) in patients with NSCLCBM treated with ICIs within 90 days of NSCLCBM diagnosis (ICI-90) and compared them to patients who never received ICIs (no-ICI). We reviewed 800 patients with LCBM who were diagnosed between 2010 and 2019 at a major tertiary care institution, 97% of whom received stereotactic radiosurgery (SRS) for local treatment of BM. OS from BM was compared between the ICI-90 and no-ICI groups using the Log-Rank test and Cox proportional-hazards model. Additionally, the impact of KRAS mutational status on the efficacy of ICI was investigated. After accounting for known prognostic factors, ICI-90 in addition to SRS led to significantly improved OS compared to no-ICI (12.5 months vs 9.1, p \u3c 0.001). In the 109 patients who had both a known PD-L1 expression and KRAS status, 80.4% of patients with KRAS mutation had PD-L1 expression vs 61.9% in wild-type KRAS patients (p = 0.04). In patients without a KRAS mutation, there was no difference in OS between the ICI-90 vs no-ICI cohort with a one-year survival of 60.2% vs 54.8% (p = 0.84). However, in patients with a KRAS mutation, ICI-90 led to a one-year survival of 60.4% vs 34.1% (p = 0.004). Patients with NSCLCBM who received ICI-90 had improved OS compared to no-ICI patients. Additionally, this benefit appears to be observed primarily in patients with KRAS mutations that may drive the overall benefit, which should be taken into account in the development of future trials
Quantum-scissors device for optical state truncation: A proposal for practical realization
We propose a realizable experimental scheme to prepare superposition of the
vacuum and one-photon states by truncating an input coherent state. The scheme
is based on the quantum scissors device proposed by Pegg, Phillips, and Barnett
[Phys. Rev. Lett. 81, 1604 (1998)] and uses photon-counting detectors, a
single-photon source, and linear optical elements. Realistic features of the
photon counting and single-photon generation are taken into account and
possible error sources are discussed together with their effect on the fidelity
and efficiency of the truncation process. Wigner function and phase
distribution of the generated states are given and discussed for the evaluation
of the proposed scheme.Comment: 11 pages, 12 figures, the final version to appear in Phys. Rev. A64,
0638xx (2001
Model independent results for and at order
Exclusive semileptonic B decays into and mesons are
investigated including order corrections using the
heavy quark effective theory. At zero recoil, the
corrections can be written in terms of the leading Isgur-Wise function for
these transitions, , and known meson mass splittings. We obtain an almost
model independent prediction for the shape of the spectrum near zero recoil,
including order corrections. We determine
from the measured branching ratio. Implications for B
decay sum rules are discussed.Comment: 11 pages, revte
Comparing the Anglo-American and Israeli-American special relationships in the Obama era: an alliance persistence perspective
The Anglo-American and Israeli-American security relationships have proved to be unusually close and have confounded expectations that they would wither away with the changing international environment. In order to explain this, the article proposes a theory of âalliance persistenceâ that is based on reciprocity over shared geostrategic interests, sentimental attachments and institutionalized security relations. The article employs this theoretical framework to explore how Anglo-American and Israeli-American relations have developed during the Obama administration. It argues that the Anglo-American relationship has been closer because of the two countriesâ shared strategic interests, whilst the Israeli-American relationship has experienced divergences in how the security interests of the two sides have been pursued. The article concludes by assessing how the two relationships will fair in the post-Obama era and argues that there are numerous areas of tension in the US-Israeli relationship that risk future tensions.
Keywords: Alliance, US-UK, US-Israel, Special Relationship, Obam
Deweyan tools for inquiry and the epistemological context of critical pedagogy
This article develops the notion of resistance as articulated in the literature of critical pedagogy as being both culturally sponsored and cognitively manifested. To do so, the authors draw upon John Dewey\u27s conception of tools for inquiry. Dewey provides a way to conceptualize student resistance not as a form of willful disputation, but instead as a function of socialization into cultural models of thought that actively truncate inquiry. In other words, resistance can be construed as the cognitive and emotive dimensions of the ongoing failure of institutions to provide ideas that help individuals both recognize social problems and imagine possible solutions. Focusing on Dewey\u27s epistemological framework, specifically tools for inquiry, provides a way to grasp this problem. It also affords some innovative solutions; for instance, it helps conceive of possible links between the regular curriculum and the study of specific social justice issues, a relationship that is often under-examined. The aims of critical pedagogy depend upon students developing dexterity with the conceptual tools they use to make meaning of the evidence they confront; these are background skills that the regular curriculum can be made to serve even outside social justice-focused curricula. Furthermore, the article concludes that because such inquiry involves the exploration and potential revision of students\u27 world-ordering beliefs, developing flexibility in how one thinks may be better achieved within academic subjects and topics that are not so intimately connected to students\u27 current social lives, especially where students may be directly implicated
Semileptonic B decays to excited charmed mesons
Exclusive semileptonic B decays into excited charmed mesons are investigated
at order in the heavy quark effective theory. Differential
decay rates for each helicity state of the four lightest excited mesons
(, , , and ) are examined. At zero recoil,
corrections to the matrix elements of the weak currents can
be written in terms of the leading Isgur-Wise functions for the corresponding
transition and meson mass splittings. A model independent prediction is found
for the slope parameter of the decay rate into helicity zero at zero
recoil. The differential decay rates are predicted, including
corrections with some model dependence away from zero
recoil and including order corrections. Ratios of various exclusive
branching ratios are computed. Matrix elements of the weak currents between
mesons and other excited charmed mesons are discussed at zero recoil to order
. These amplitudes vanish at leading order, and can be
written at order in terms of local matrix elements.
Applications to decay sum rules and factorization are presented.Comment: 39 pages revtex including 10 figures, uses epsf. Substantial
improvements throughout the pape
An SU(3) model for octet baryon and meson fragmentation
The production of the octet of baryons and mesons in e^+ e^- collisions is
analysed, based on considerations of SU(3) symmetry and a simple model for
SU(3) symmetry breaking in fragmentation functions. All fragmentation
functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member
of the baryon octet (and similarly for fragmentation into members of the meson
octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x,
Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3)
breaking parameter, \lambda, the model is successful in describing
hadroproduction data at the Z pole. The fragmentation functions are then
evolved using leading order evolution equations and good fits to currently
available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file
The CADENCE Pilot Trial â Promoting Physical Activity in Bladder Cancer Survivors: A Protocol Paper
Background:
Participation in physical activity has been found to be beneficial for mental and physical health outcomes among cancer survivors. However, to date no intervention exists specifically to promote physical activity among bladder cancer survivors. In light of this knowledge a home-based exercise intervention was co-created for those recently diagnosed with bladder cancer.
Aim:
The aim of the present study, financially supported by Action Bladder Cancer UK [1], is to pilot the home-based exercise intervention tailored specifically for bladder cancer survivors (i.e. from the point of diagnosis) to improve physical and mental health outcomes (during treatment and beyond) in this population.
Methods:
This study will use a randomised controlled trial design. Arm one will consists of the 14 week home-based exercise intervention and arm two usual care (15 participants will be randomised to each arm). Baseline data collection will take place shortly after clinical diagnosis of bladder cancer, and follow-up approximately 7 weeks and then again approximately 14 weeks after commencement of the intervention. At each data collection point data will be collected from participants relating to demographics, physical and mental health. Participants will aslo be asked to wear an Actigraph Accelerometer at each data collection point for seven consecutive days. Immediately after baseline data collection participants in the intervention arm will be given the home-based exercise booklet.
Ethics and dissemination:
Ethical approval was obtained for the present study via The London- City and East Research Ethics Committee (ID:291676). Results of this study will be disseminated through peer-reviewed publications and scientific presentations
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