A Comparison of Muscle Tension and General Motor Ability

The two purposes of this study are (1) to determine the relationship between muscular tension, as evidenced by inward and outward rotation of the lower extremities, and a general motor ability test; and (2) to determine the relationship between muscular tension as evidenced by hip flexion and a general motor ability test

Aurora Volume 42

College formerly located at Olivet, Illinois and known as Olivet University, 1912-1923; Olivet College, 1923-1939, Olivet Nazarene College, 1940-1986, Olivet Nazarene University, 1986-https://digitalcommons.olivet.edu/arch_yrbks/1108/thumbnail.jp

Aurora Volume 42

College formerly located at Olivet, Illinois and known as Olivet University, 1912-1923; Olivet College, 1923-1939, Olivet Nazarene College, 1940-1986, Olivet Nazarene University, 1986-https://digitalcommons.olivet.edu/arch_yrbks/1108/thumbnail.jp

Timing th Market - A Study on Successful Market Timing

The purpose of this study is to clarify to what extent managers engage in successful market timing behavior in UK by issuing equity on the London Stock Exchange due to an information advantage, while investors fail to identify and compensate for this discrepancy. During the timeframe 1999-2008, the indicator preference for equity had a result supporting the presences of successful market timing behavior. However, the other two indicators, equity ratio change and time since last quarterly report did not support our theory, and as a result the findings must be considered inconclusive

Bioinformatic tools to alleviate the annotation bottleneck within precision oncology

In the era of advanced ability to perform complex genomic sequencing, precision oncology has been adopted as the ideal paradigm for optimization of outcomes for patients with cancer. However, despite technological advances in all aspects of the massively parallel sequencing pipeline, the application of precision oncology to every clinical workflow has been unattainable. Suboptimal adoption of custom medicine within oncology is attributable to the annotation bottleneck, which currently demands inordinate manual and computational requirements for completion. Alleviation of the annotation bottleneck requires co-development of bioinformatic strategies and analysis knowledgebanks to automate variant identification and variant annotation for clinical utility. The body of work presented here provides validated methods to alleviate the annotation bottleneck within the precision oncology pipeline. The introduction describes the specific aspects of the massively parallel sequencing pipeline that require development. Subsequently, we present three tools (DeepSVR, a Manual Review Standard Operating Procedure, and OpenCAP) that were developed to improve upon existing methods for variant identification and annotation. DeepSVR provides a machine learning approach to improve automated somatic variant calling by reducing false positives associated with sequencing pipelines that are observable by manual reviewers. The Manual Review Standard Operating Procedure provides a systemic and standardized approach for manual review of aligned sequencing reads for sequencing data with paired tumor and normal samples. Finally, the Open-sourced CIViC Annotation Pipeline (OpenCAP) serves as a software to create rationally designed clinical capture panels that are linked to clinical relevance summaries to improve library preparation and clinical annotation. The combined utility of these three tools for alleviation of the analysis bottleneck are demonstrated using a clinical example. Specifically, we developed a targeted clinical capture panel (MyeloSeq) to evaluate recurrent mutations observed in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The MyeloSeq sequencing pipeline incorporated many of the tools described above for variant identification and annotation and provides a succinct output report for physician consumption. When surveying physicians who utilize the MyeloSeq panel, we observed that over 44% of physicians changed their treatment protocol based on the MyeloSeq results. This included 39 new therapeutics prescribes, 4 definitive diagnoses, and 13 changes in treatment plan (stem-cell transplant versus chemotherapy) based on prognostic indicators. This example demonstrates that the developed tools help alleviate the analysis bottleneck within precision oncology and will improve physician’s ability to integrate precision medicine into clinical workflow

Fiber-Reinforced Epoxy Composites and Methods of Making Same Without the Use of Oven or Autoclave

Method embodiments for producing a fiber-reinforced epoxy composite comprise providing a mold defining a shape for a composite, applying a fiber reinforcement over the mold, covering the mold and fiber reinforcement thereon in a vacuum enclosure, performing a vacuum on the vacuum enclosure to produce a pressure gradient, insulating at least a portion of the vacuum enclosure with thermal insulation, infusing the fiber reinforcement with a reactive mixture of uncured epoxy resin and curing agent under vacuum conditions, wherein the reactive mixture of uncured epoxy resin and curing agent generates exothermic heat, and producing the fiber-reinforced epoxy composite having a glass transition temperature of at least about 100.degree. C. by curing the fiber reinforcement infused with the reactive mixture of uncured epoxy resin and curing agent by utilizing the exothermically generated heat, wherein the curing is conducted inside the thermally insulated vacuum enclosure without utilization of an external heat source or an external radiation source